A5014971828- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Magnetic properties of thin films
- Metal and Thin Film Mechanics
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- ZnO doping and properties
- Analytical Chemistry and Chromatography
- Phytoestrogen effects and research
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Food Quality and Safety Studies
- Flavonoids in Medical Research
- Piperaceae Chemical and Biological Studies
- Tryptophan and brain disorders
- Metabolism, Diabetes, and Cancer
- Biological Activity of Diterpenoids and Biflavonoids
- Semiconductor materials and interfaces
- Chromatography in Natural Products
- Antimicrobial Peptides and Activities
- Marine Toxins and Detection Methods
- Medicinal plant effects and applications
- Plant-based Medicinal Research
- Cancer, Hypoxia, and Metabolism
Australian Regenerative Medicine Institute
2025
Monash University
2025
Nanjing University of Chinese Medicine
2014-2025
Seoul National University
2010-2011
Nanjing University
2011
Institute of Semiconductors
2002-2008
Chinese Academy of Sciences
2002-2008
University of Science and Technology Beijing
1999-2003
Institute of Physics
2000-2001
Pyruvate kinase M2 (PKM2), playing a central role in regulating aerobic glycolysis, was considered as promising target for cancer therapy. However, its metastasis is rarely known. Here, we found tight relationship between PKM2 and breast metastasis, demonstrated by the findings that beta-elemene (β-elemene), an approved drug complementary therapy, exerted distinct anti-metastatic activity dependent on PKM2. The results indicated β-elemene inhibited cell migration, invasion vitro well...
Eucommia ulmoides Oilv. (EU), also called Du-zhong, is a classical traditional Chinese medicine. Its bark, leaf, and male flower are all used for medicinal purposes, Eucommiae Cortex (EC), Folium (EF), Flos Male (EFM). In order to study the difference in synthesis accumulation of metabolites different parts EU, reliable method based on ultra-fast liquid chromatography tandem triple quadrupole mass spectrometry (UFLC-QTRAP-MS/MS) was developed simultaneous determination total 21 constituents,...
Primary malignant bone tumors are the third highest cause of cancer-related mortality among patients under age 20. X-ray scan is primary tool for detecting tumors. However, due to varying morphologies tumors, it challenging radiologists make a definitive diagnosis based on radiographs. With recent advancement in deep learning algorithms, there surge interest computer-aided Nonetheless, development this field has been hindered by lack publicly available datasets To tackle challenge, we...
A sensitive and rapid method was developed to evaluate the flavonoids, iridoid glycosides, phenolic acids in Gardenia jasminoides J. Ellis (GJE) from various regions, utilizing multiple reaction monitoring (MRM) of UFLC/QTRAP-MS conjunction with principal component analysis (PCA) for simultaneous quantification. The findings revealed that all target constituents were accurately identified GJE samples, confirming method's efficacy concurrent determination 21 chemicals. Notable discrepancies...
ABSTRACT Using LC–MS to screen and analyse the characteristics of components biological systems is a new approach study pharmacological substance basis traditional Chinese medicine, which has strong novelty in analytical science. This analyses antidepressant material Zhizichi decoction through integration strategy serum pharmacochemistry, network pharmacology immunoreactivity verification, helps overcoming limitations TCM research provided perspective for studying ZZCD. First all, blood from...
To evaluate the flavonoids, iridoid glycosides, phenolic acids, free amino acids and nucleosides contents in Zhi-zi-chi decoction (ZZCD), a sensitive rapid method was developed using UFLC/QTRAP-MS for simultaneous quantification. The results showed that all known ingredients were determined ZZCD suitable determination of 53 target components ZZCD. Of which three isoflavones, nine eight glycosides main constituents. This study simultaneously 5 major categories first time made up blank on...
ABSTRACT In this study, Balb/c mice were subjected to chronic unpredictable mild stress (CUMS) and treated with Zhi‐zi‐chi Decoction (ZZCD). Using a hippocampal lipidomics approach that combined ultra performance liquid chromatography (UPLC)‐Q‐Exactive Orbitrap MS multivariate statistical techniques targeted metabolic pathway analysis, we identified potential lipid metabolites pathways associated depression. Meanwhile, anti‐inflammatory analyses conducted in the hippocampus of mice. The...
Ta/NiO/NiFe/Ta multilayers were prepared by rf reactive and dc magnetron sputtering. The exchange coupling field between NiO NiFe reached 120 Oe. composition chemical states at the interface region of NiO/NiFe studied using x-ray photoelectron spectroscopy (XPS) peak decomposition technique. results show that there are two thermodynamically favorable reactions interface: NiO+Fe=Ni+FeO 3NiO+2Fe=3Ni+Fe2O3. thickness reaction as estimated angle-resolved XPS was about 1–1.5 nm. These products...
Pseudostellariae Radix (PR) is an important traditional Chinese herbal medicine (TCM) with vast clinical consumption because of its positive effects. However, little attention has been devoted to simultaneous analysis bioactive components for quality control PR based on different harvesting times, growing habitats, and processing methods. In this research, the was evaluated determination multiple combined grey relational (GRA). A reliable method ultra-fast liquid chromatography tandem triple...
Lonicerae Japonicae Flos (LJF) and (LF) belong to different genera of Caprifoliaceae. They have been historically utilised as herbal medicine treat various diseases. However, the comprehensive assessment them still remains a challenge.To develop method ultra-fast liquid chromatography-tandem triple quadrupole mass spectrometry (UFLC-QTRAP-MS/MS) coupled with multivariate statistical analysis for quality evaluation reveal differential components LJF LF.A validated UFLC-QTRAP-MS/MS was...
Perillae Folium (PF), which is extensively used as a dietary vegetable and medicinal herb, contains two varietal forms corresponding to purple perilla leaf (Perilla frutescens var. crispa) green frutescens). However, the components efficacy of different PF varieties remain underexplored so far. In present work, nontargeted rapid resolution liquid chromatography coupled with quadruple-time-of-flight mass spectrometry (RRLC-Q/TOF-MS)-based metabolomics approach was developed investigate...
Ta/NiO x / Ni 81 Fe 19 /Ta multilayers were prepared by rf reactive and dc magnetron sputtering. The exchange-coupling field (Hex) the coercivity (Hc) of NiOx/Ni81Fe19 as a function ratio Ar to O2 during deposition process studied. composition chemical states at interface region NiOx/NiFe also investigated using x-ray photoelectron spectroscopy (XPS) peak decomposition technique. results show that has great effect on nickel in NiOx film. When is equal 7 argon sputtering pressure 0.57 Pa,...
Spatholobi Caulis (SC), the vine stem of Spatholobus suberectus Dunn, is a widely used traditional Chinese medicine (TCM) for treatment blood stasis syndrome and related diseases. Xylem phloem are main structures SC color xylem in red brown or while with resin secretions reddish to dark brown. They alternately arranged plurality concentric eccentric rings. In order investigate distribution patterns metabolites SC, an analytical method based on UFLC-QTRAP-MS/MS was established simultaneous...
Advanced lung cancer has poor prognosis owing to its low sensitivity current chemotherapy agents. Therefore, discovery of new therapeutic agents is urgently needed. In this study, we investigated the antitumor effects peperomin E , a secolignan isolated from Peperomia dindygulensis frequently used C hinese folk medicine for treatment. The results indicate that antiproliferative effects, promoting apoptosis and cell cycle arrest in non‐small‐cell ( NSCLC ) lines dose‐dependent manner, while...
Leaves of Platycladus orientalis have been used as blood cooling and homeostatic therapy for thousands years in traditional Chinese medicine. Emerging evidences modern pharmacology proved flavonoids the key elements responsible efficacies. However, there has no report on pharmacokinetic study from leaves extract. In this study, a sensitive rapid ultra-flow liquid chromatography-tandem mass spectrometry method was established validated simultaneous determination amentoflavone, afzelin,...
Recent studies have examined lipophilic marine toxins (LMTs) in shellfish and toxic algae worldwide, but the occurrence seasonal variations of LMTs commercial clams (including Mactra veneriformis, Ruditapes philippinarum, Meretrix meretrix, Cyclina sinensis) at their major culturing area Jiangsu, China, remain largely unexplored. In this study, a new solid phase extraction (SPE) combination with an ultra-fast liquid chromatography triple-quadrupole linear ion trap mass spectrometry...
Apocyni Veneti Folium (AVF) is a kind of staple traditional Chinese medicine with vast clinical consumption because its positive effects. However, due to the habitats and adulterants, quality uneven. To control this medicinal herb, in study, AVF was evaluated based on simultaneous determination multiple bioactive constituents combined multivariate statistical analysis. A reliable method ultra-fast liquid chromatography tandem triple quadrupole mass spectrometry (UFLC-QTRAP-MS/MS) developed...