A5066469223- Antimicrobial Peptides and Activities
- Toxin Mechanisms and Immunotoxins
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- Ginseng Biological Effects and Applications
- Wound Healing and Treatments
- Bacterial biofilms and quorum sensing
- Metabolism, Diabetes, and Cancer
- Transgenic Plants and Applications
- Aquaculture disease management and microbiota
- Biological Activity of Diterpenoids and Biflavonoids
- Chromatography in Natural Products
- Nanopore and Nanochannel Transport Studies
- Pharmacogenetics and Drug Metabolism
- Cutaneous lymphoproliferative disorders research
- Fibroblast Growth Factor Research
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- RNA Interference and Gene Delivery
- Cellular Mechanics and Interactions
- Lymphatic System and Diseases
- Connective tissue disorders research
- Rabies epidemiology and control
- Virology and Viral Diseases
- Advanced biosensing and bioanalysis techniques
Guiyang Medical University
2025
Affiliated Hospital of Guizhou Medical University
2025
North Sichuan Medical University
2020-2023
Fujian Normal University
2022
Nanjing University of Chinese Medicine
2018-2019
Novartis (China)
2019
Hebei Medical University
2019
Massachusetts General Hospital
2016-2017
Harvard University
2016-2017
Jilin University
2014-2015
Pelvic organ prolapse (POP) is a common condition affecting almost half of women over the age 50. The molecular and cellular mechanisms underlying this condition, however, remain poorly understood. Here we have reported that fibulin-5, an integrin-binding matricellular protein essential for elastic fiber assembly, regulated activity MMP-9 to maintain integrity vaginal wall prevented development POP. In murine stromal cells, fibulin-5 inhibited β1 integrin–dependent, fibronectin-mediated...
Pyruvate kinase M2 (PKM2), playing a central role in regulating aerobic glycolysis, was considered as promising target for cancer therapy. However, its metastasis is rarely known. Here, we found tight relationship between PKM2 and breast metastasis, demonstrated by the findings that beta-elemene (β-elemene), an approved drug complementary therapy, exerted distinct anti-metastatic activity dependent on PKM2. The results indicated β-elemene inhibited cell migration, invasion vitro well...
Aerobic glycolysis plays a decisive role in cancer growth. However, its metastasis was rarely understood. Cantharidin natural compound from an arthropod insect cantharis exerts potent anticancer activity. Here we found cantharidin possesses significant anti-metastatic activity on breast dependent inhibition of aerobic glycolysis. indicates migration and invasion cells, angiogenesis vitro, inhibits cells metastasizing to liver lung vivo. Subsequent results revealed that decreases the...
Quorum sensing (QS) can regulate the pathogenicity of bacteria and production some virulence factors. It is a promising target for screening to find anti-virulence agents in coming post-antibiotics era. Cyclo (L-Trp-L-Ser), one variety cyclic dipeptides (CDPs), isolated from marine bacterium Rheinheimera aquimaris, exhibited anti-QS activity against Chromobacterium violaceum CV026 Pseudomonas aeruginosa PAO1. Unlike CDPs composed phenylalanine or tyrosine, has been widely studied; however,...
CD19 is expressed on normal and neoplastic B cells a promising target for immunotherapy. However, there still an unmet need to further develop novel therapeutic drugs the treatment of refractory/relapsing human CD19+ tumors. We have developed diphtheria toxin-based anti-human immunotoxin targeting constructed three isoforms immunotoxin: monovalent, bivalent, foldback diabody. In vitro binding affinity efficacy analysis demonstrated that bivalent isoform had highest in efficacy. The vivo...
Abstract Lysozyme can kill bacteria by its enzymatic activity or through a mechanism involving cationic nature, which facilitate electrostatic interactions with the viral capsid, negatively charged parts of nucleic acids, and polymerase, so binding to acids may be another biological function lysozyme. Here, PCR was used as research tool detect effects lysozyme on replication transcription after treatment in different ways. We found that hydrolysate enter cells inhibit varying degrees vitro,...
Two new dammarane-type triterpene sapogenins were isolated from the Chinese red ginseng. The named as 24,26-dihydroxy-panaxdiol (1) and 24-hydroxy-panaxdiol (2). Their structures elucidated by combined analysis of NMR mass spectrometry 20(S),25(R)-epoxydammarane-3β,12β,24β,26-tetraol 20(S),25-epoxydammarane-3β,12β,24α-triol complete signal assignments two compounds carried out 2D spectral NOE differential spectroscopy analysis.
A new minor C-3 epimer of ocotillol, named 3α-ocotillol (1), was isolated along with ocotillol (2) from the stems and leaves American ginseng for first time. The structure sapogenin elucidated as (20S, 24R)-dammar-20,24-epoxy-3α,6α,12β,25-tetraol by combination analysis NMR mass spectrometry. complete signal assignments two compounds were carried out means 2D spectral analysis.
A new dammarane-type triterpenoid compound was isolated from stems and leaves of American ginseng. The structure the sapogenin elucidated by combined analysis NMR HR-ESI-MS as dammar-20S, 25S-epoxy-3β, 12β, 26-triol (1). Compound 1 showed cytotoxic effect on human SM7721 Hela cells in vitro.
Pyruvate kinase M2 (PKM2) plays a central role in regulating aerobic glycolysis and is considered as potential target for cancer therapy. However, its metastasis rarely known. Here, we found tight relationship between PKM2 breast metastasis, which demonstrated by the finding that beta-elemene (β-elemene), an approved drug complementary therapy, exerted distinct anti-metastatic activity dependent on PKM2. The results indicated thatβ-elemene inhibited cell migration, invasion angiogenesis....
Objective To investigate the expression of LncRNA TCONS_00003757 in papillary thyroid carcinoma(PTC), and to explore effect on proliferation, migration, invasion TPC-1 cells. Methods Sixty cases carcinoma specimens paired normal tissues were collected after surgery from October 2017 March 2018 Tangshan Workers Hospital. Real-time PCR analysis was used examine level PTC tissues, association levels with clinicopathological data patients analyzed. The effects ST3GAL5 silencing cells...