A5102811326- Animal Virus Infections Studies
- Protein Kinase Regulation and GTPase Signaling
- Virus-based gene therapy research
- Toxoplasma gondii Research Studies
- RNA Interference and Gene Delivery
- Microbial infections and disease research
- Peroxisome Proliferator-Activated Receptors
- Hepatitis B Virus Studies
- Virology and Viral Diseases
- Meat and Animal Product Quality
- Bioactive Compounds and Antitumor Agents
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Synthesis and Biological Evaluation
- Cancer, Lipids, and Metabolism
- Biological and pharmacological studies of plants
- Herpesvirus Infections and Treatments
- Synthesis and Reactions of Organic Compounds
- Respiratory viral infections research
- Genomics, phytochemicals, and oxidative stress
- Drug-Induced Adverse Reactions
- RNA and protein synthesis mechanisms
- Viral gastroenteritis research and epidemiology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Marine Biology and Environmental Chemistry
Chinese Academy of Agricultural Sciences
2011-2023
Animal Science Research Institute
2011-2021
Institute of Animal Sciences
1992-2019
Institute of Animal Science
2014
Beijing Fengtai Hospital
2014
Shanghai Ocean University
2012
Qingdao Institute of Animal Husbandry and Veterinary Medicine
2012
Animal Husbandry & Veterinary
2012
Indiana University School of Medicine
2011
China Agricultural University
2009-2011
Bovine parainfluenza virus type 3 (BPIV3) is one of the most important known viral respiratory pathogens both young and adult cattle. It also named “heat stress in transport”, causing morbidity mass death. New variants BPIV3 have been detected or isolated China since 2008. Here, we isolate strain (named BJ) Madin-Darby bovine kidney (MDBK) cells from nasal samples collected China. Phylogenetic analysis showed that our related to genotype A. The comparison BPIV3-BJ reference Chinese NM09...
The pharmacokinetics of tizoxanide (T), the active metabolite nitazoxanide (NTZ), and its protein binding ability in goat plasma solutions albumin alpha-1-acid-glycoprotein were investigated. samples analyzed using a high-performance liquid chromatography (HPLC) assay with UV detection at 360 nm. concentration T was detectable goats up to 24 h. Plasma concentrations vs. time data after 200 mg/kg oral administration NTZ adequately described by one-compartment open model first order...
Peste des petits ruminants (PPR) is an acute, febrile, viral disease of small that has a significant economic impact. For many diseases, vaccination with virus-like particles (VLPs) shown considerable promise as prophylactic approach; however, the processes assembly and release peste virus (PPRV) VLPs are not well characterized, their immunogenicity in host unknown. In this study, PPRV were generated baculovirus system through simultaneous expression matrix (M) protein hemaglutin (H) or...
Chronic hepatitis B virus (HBV) infection is an independent risk factor for the development of hepatocellular carcinoma (HCC). The HBV HBx gene frequently identified as integrant in chromosomal DNA patients with HCC. encodes X protein (HBx), a putative viral oncoprotein that affects transcriptional regulation several cellular genes. Therefore, may be ideal target to impede progression infection-related In this study, integrated was transcriptionally downregulated using artificial...
The immunogenicity of a DNA vaccine expressing the surface protein NcSRS2 Neospora caninum was studied in BALB/c mice. NcSRS2-encoding obtained by PCR amplification ORF gene from p43 plasmid encoding N. NcSRS2, ligated to mammalian expression vector pcDNA3.1/Zeo(+) and propagated E. coli DH5α produce vaccine. mice were immunised two intramuscular injections with or without complete Freund’s adjuvant (CFA). Serum antibody titres nitric oxide (NO) concentrations, splenocyte proliferation...
An optimized method based on tetracycline-inducible gene expression system T-REx was developed to screen and evaluate Tet repressor (TetR)-expressing cell lines using enhanced green fluorescence protein (EGFP) as reporter gene. To verify the effectiveness of method, two TetR-expressing Chinese hamster ovary (CHO) lines, CHO-TR B2 (stringent) B5 (less stringent), in which EGFP genes were variantly controlled by tetracycline, used construct expressing anti-apoptosis survivin upon induction...
Abstract Epithelial ovarian cancer (EOC) causes estimated 13,850 deaths in 2010 the United State. More effective treatment regimens are urgently required for this deadly disease. We and others have obtained ample evidence indicating that lysophosphatidic acid (LPA) plays an important role EOC development. recently shown levels of LPA several other bioactive lipids tumor environment regulated by Group VIA calcium-independent phospholipase A2 beta (iPLA2β) expressed microenvironment,...