A5008508333- Ovarian cancer diagnosis and treatment
- Testicular diseases and treatments
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Neuroendocrine Tumor Research Advances
- Sarcoma Diagnosis and Treatment
- Urologic and reproductive health conditions
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Cervical Cancer and HPV Research
- Blood properties and coagulation
- Angiogenesis and VEGF in Cancer
- Soft tissue tumor case studies
- Renal and related cancers
- Prostate Cancer Treatment and Research
- Cancer Mechanisms and Therapy
- Urological Disorders and Treatments
- MicroRNA in disease regulation
- Gastrointestinal Tumor Research and Treatment
- Cancer Cells and Metastasis
- Endometrial and Cervical Cancer Treatments
- Renal cell carcinoma treatment
- Cancer and Skin Lesions
- Intraperitoneal and Appendiceal Malignancies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Indiana University – Purdue University Indianapolis
2013-2024
Indiana University School of Medicine
2012-2021
Indiana University Health
2012-2021
Indiana University Indianapolis
2014-2021
University of Indianapolis
2021
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
2018
Indiana University
2006-2016
Howard Hughes Medical Institute
2015
National Institutes of Health
2015
Richard L. Roudebush VA Medical Center
2012
Abstract BACKGROUND: A study was undertaken to use the 2‐tier system reclassify grade of serous ovarian tumors previously classified using International Federation Gynecology and Obstetrics (FIGO) 3‐tier determine progression‐free survival (PFS) overall (OS) patients treated on Gynecologic Oncology Group (GOG) Protocol 158. METHODS: The authors retrospectively reviewed demographic, pathologic, data 290 with stage III carcinoma surgery chemotherapy GOG 158, a cooperative multicenter group...
Tissue transglutaminase (TG2) is involved in Ca(2+)-dependent aggregation and polymerization of proteins. We previously reported that TG2 mRNA up-regulated epithelial ovarian cancer (EOC) cells compared with normal epithelium. Here, we show overexpression the protein tumors its secretion ascites fluid define role EOC. By stable knockdown overexpression, enhances EOC cell adhesion to fibronectin directional migration. This phenotype preserved vivo, where pattern tumor dissemination peritoneal...
Abstract Purpose: Aggressive pancreatic cancer is commonly associated with a dense desmoplastic stroma, which forms protective niche for cells. The objective of the study was to determine functions tissue transglutaminase (TG2), Ca2+-dependent enzyme that cross-links proteins through transamidation and abundantly expressed by cells in stroma. Experimental Design: Orthotopic xenografts coculture systems tested mechanisms modulates tumor–stroma interactions. Results: We show TG2 secreted...
Metastatic colonization involves paracrine/juxtacrine interactions with the microenvironment inducing an adaptive response through transcriptional regulation. However, identities of transcription factors (TFs) induced by metastatic in ovarian cancer (OC) and their mechanism action is poorly understood. Using organotypic 3D culture model recapitulating early events metastasis, we identified ETS1 as most upregulated member ETS family TFs metastasizing OC cells they interacted microenvironment....
Significance Why women carrying a pathogenic germline BRCA1 mutation are predisposed to ovarian and breast cancer remains elusive. This study points progesterone as culprit. Generally, -mutation carriers exhibit high yet individually varying levels of during the menstrual cycle. Although not all develop these cancers, them advised undergo prophylactic surgeries at young age (under 40 y 45 y) prevent cancer. Insights from robust in vivo findings this offer novel concept: Targeting signaling...
Intraductal papillary mucinous neoplasms (IPMN) have been considered difficult to diagnose by fine-needle aspiration (FNA) cytology. We identified 57 cases diagnosed as IPMN or consistent with endoscopic ultrasound (EUS)-guided FNA over a 9-yr period. Histologic follow-up was available for 20 patients (35%). Pancreatic neoplasia demonstrated in 18 of these (90%). The histologic diagnoses were (16 cases), pancreatic intraductal (grade 1b, 1 case), invasive mucin-producing adenocarcinoma (1...
Abstract BACKGROUND. Ovarian tumors frequently express c‐Kit and/or platelet‐derived growth factor receptors (PDGFRs). Imatinib mesylate blocks the of ovarian cancer cells in vitro and may enhance activity chemotherapy. This study was conducted to determine imatinib combination with docetaxel patients recurrent, platinum‐resistant epithelial (EOC). METHODS. Eligible had platinum‐resistant, or refractory EOC that expressed PDGFRα c‐kit, as determined by immunohistochemistry. at a dose 600 mg...
AbstractWe identified the platelet derived growth factor receptor (PDGFR) as a potential target in epithelial ovarian carcinoma (EOC). This led us to test whether inhibition of PDGFR affects cancer cell proliferation and survival regulates other processes critical tumor metastasis. We postulated that there is correlation between PDGF-PDGFR axis secretion VEGF EOC. tumors, cells, serum ascites fluid was measured by IHC, Western Blot ELISA. found increased expression most tumors (by IHC), EOC...
Tissue transglutaminase 2 (TG2) is overexpressed in epithelial ovarian cancer (EOC) and promotes intraperitoneal metastasis. How TG2 facilitates the spread of EOC unknown. Here, we show that regulates expression function matrix metalloproteinase-2 (MMP-2), a critical mediator tissue invasiveness. knockdown down-regulates MMP-2 protein mRNA SKOV3, IGROV-1, MDA-MB-436, PC-3 cells. or inhibition activity using KCC009 decreases gelatinase are regulated by at transcriptional level, as...
Tissue transglutaminase (TG2) is a multifunctional protein that binds to fibronectin and exerts transamidating activity in the presence of Ca2+. We previously reported TG2 upregulated ovarian tumors enhances intraperitoneal (i.p.) metastasis. secreted abundantly cancer (OC) ascites as an active enzyme, yet its function extracellular compartment remains unknown. To study distinct functions TG2, we used recombinant His6-tagged catalytically inactive enzyme vitro vivo. By using i.p. orthotopic...
Metastasis is responsible for 90% of human cancer mortality, yet it remains a challenge to model metastasis in vivo. Here we describe mouse models high-grade serous ovarian cancer, also known as carcinoma (HGSC), the most common and deadliest type. Mice genetically engineered harbor Dicer1 Pten inactivation mutant p53 robustly replicate peritoneal metastases HGSC with complete penetrance. Arising from fallopian tube, tumors spread ovary metastasize throughout pelvic cavities, invariably...