A5015735346- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Cervical Cancer and HPV Research
- Biomimetic flight and propulsion mechanisms
- Sarcoma Diagnosis and Treatment
- Robotic Locomotion and Control
- Intraperitoneal and Appendiceal Malignancies
- Chemotherapy-induced organ toxicity mitigation
- Insect and Arachnid Ecology and Behavior
- Endometriosis Research and Treatment
- Estrogen and related hormone effects
- Gestational Trophoblastic Disease Studies
- Colorectal and Anal Carcinomas
- Neurobiology and Insect Physiology Research
- Muscle activation and electromyography studies
- Genital Health and Disease
- Sports Performance and Training
- Reproductive Biology and Fertility
- Plant and Biological Electrophysiology Studies
- Animal Behavior and Reproduction
- Polyomavirus and related diseases
- Amphibian and Reptile Biology
- Cancer-related Molecular Pathways
- Vascular Tumors and Angiosarcomas
University of Lincoln
2019-2024
Time Warner (United States)
2019-2021
University of California, Irvine
2019
University of Bristol
2012-2018
University of Cambridge
2008-2016
Dignity Health
2016
Roswell Park Comprehensive Cancer Center
1993-2016
Memorial Sloan Kettering Cancer Center
2005-2016
St. Joseph's Hospital and Medical Center
2016
Maine Medical Center
2016
PURPOSE: To assess progression-free survival (PFS) and overall (OS) in patients with suboptimally debulked epithelial ovarian cancer receiving cisplatin (100 mg/m 2 ) or 24-hour infusion paclitaxel (200 the combination of (135 followed by (75 ). PATIENTS AND METHODS: After stratification for disease measurability, were randomized to receive six cycles one treatments every 3 weeks. If measurable, complete response (CR) partial (PR) was determined. RESULTS: Six hundred fourteen 648 who entered...
Hop, skip, jump, or massive leap In biological and engineered systems, an inherent trade-off exists between the force velocity that can be delivered by a muscle, spring, combination of two. However, one amplify maximum throwing power arm storing energy in bow sling shot with latch mechanism for sudden release. Ilton et al. used modeling to explore performance motor-driven versus spring-latch systems engineering biology across size scales. They found range general principles are common...
Many insects jump by storing and releasing energy in elastic structures within their bodies. This allows them to release large amounts of a very short time at high speeds. The fastest the insect jumpers, froghopper, uses catapult-like mechanism achieve jumping prowess which energy, generated slow contraction muscles, is released suddenly power rapid synchronous movements hind legs. How this stored? coxae froghopper are linked hinges ipsilateral wings pleural arches, complex bow-shaped...
Abstract BACKGROUND: Between 30% and 50% of women who have high‐grade uterine leiomyosarcoma (uLMS) limited to the uterus at diagnosis remain progression‐free 2 years. Adjuvant pelvic radiation does not improve outcome. The objective current study was determine 2‐year 3‐year survival (PFS) among a prospective cohort received adjuvant gemcitabine plus docetaxel followed by doxorubicin. METHODS: Women with uterus‐limited, uLMS adequate organ function were eligible. Within 12 weeks complete...
SUMMARY It has long been established that fleas jump by storing and releasing energy in a cuticular spring, but it is not known how forces from spring are transmitted to the ground. One hypothesis recoil of pushes trochanter onto ground, thereby generating jump. A second acts through lever system push tibia tarsus To decide which these two hypotheses correct, we built kinetic model simulate different possible velocities accelerations produced each proposed process compared those simulations...
Joint Action Many small insects are impressive jumpers, but large leaps and bodies pose biomechanical challenges. Burrows Sutton (p. 1254 ) show that the nymphal planthopper Issus has interlocking gears on their hindleg trochanters act together to cock legs synchronously before triggering forward jumps. At final molt, swapped for a high-performance friction-based mechanism because risk of breaking gear is high, options repair during molting gone, and, moreover, animal bigger stronger.
Ifosfamide (isophosphamide) and mesna (2-mercaptoethane sodium sulfonate) were administered intravenously at monthly intervals to 46 patients with advanced epithelial ovarian carcinoma refractory or recurrent after cisplatin-containing combination chemotherapy. Initially, ifosfamide was given as 1.5 g/m2/d x 5 days 300 mg/m2 every 4 hours for three doses following ifosfamide, but the initial dose of reduced 1.2 g/m2 because toxicity. Four initially entered found be ineligible: two who had...
Fifty-six patients were randomly assigned to receive either one-day cisplatin, doxorubicin, and cyclophosphamide (PAC) chemotherapy (PAC-I) or five-day PAC (PAC-V) for advanced epithelial ovarian carcinoma. Follow-up has been 120+ months death. Ninety-one percent had suboptimal stage III IV disease 55% grade 2 3 lesions. Two died of toxicity free at autopsy. A third patient congestive heart failure with no 103 months. Additionally, eight a negative second-look laparotomy, three (37.5%) are...
Purpose The vascular disrupting agent fosbretabulin tromethamine selectively targets pre-existing tumor vasculature, which causes shutdown and leads to cancer cell death necrosis. Antiangiogenesis agents such as bevacizumab, a humanized antivascular endothelial growth factor monoclonal antibody, might prevent revascularization during after treatment with agent. Patients Methods recurrent or persistent epithelial ovarian, tubal, peritoneal carcinoma, measurable detectable disease, three fewer...
As animals get smaller, their ability to generate usable work from muscle contraction is decreased by the muscle's force-velocity properties, thereby reducing effective jump height. Very small use a spring-actuated system, which prevents velocity effects available energy. Since properties reduce in even larger animals, why don't jumping systems as well? We will show that length-tension limit generating maximum one-third of possible could produce-greatly restricting height jumpers. Thus...