A5101706522- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Plant Pathogens and Fungal Diseases
- Plant nutrient uptake and metabolism
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- Erythrocyte Function and Pathophysiology
- Radiomics and Machine Learning in Medical Imaging
- Sphingolipid Metabolism and Signaling
- Legume Nitrogen Fixing Symbiosis
- Computational Drug Discovery Methods
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Wnt/β-catenin signaling in development and cancer
- Cancer Genomics and Diagnostics
- Mycotoxins in Agriculture and Food
- Photosynthetic Processes and Mechanisms
- Immune Cell Function and Interaction
- Endometrial and Cervical Cancer Treatments
- Agriculture, Soil, Plant Science
- Cellular Mechanics and Interactions
- Cancer Mechanisms and Therapy
The Seventh Affiliated Hospital of Sun Yat-sen University
2022-2025
Sun Yat-sen University
2022-2025
Vanderbilt University Medical Center
2021-2024
Yunnan Agricultural University
2014-2024
Lanzhou University
2016-2024
First Hospital of Lanzhou University
2016-2024
University of Notre Dame
2007-2023
First Affiliated Hospital of Zhengzhou University
2019-2022
Southwest Medical University
2021
Cancer Research Institute
2015-2021
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancy, with high mortality attributable to widespread intraperitoneal metastases. Recent meta-analyses report an association between obesity, incidence, and survival, but effect obesity on metastasis has not been evaluated. The objective this study was use integrative approach combining in vitro, ex vivo, vivo studies test hypothesis that contributes metastatic success. Initial vitro using three-dimensional...
The noncanonical Wnt ligand Wnt5a is found in high concentrations ascites of women with ovarian cancer. In this study, we elucidated the role cancer metastasis. promoted tumor cell adhesion to peritoneal mesothelial cells as well migration and invasion, leading colonization explants. Host components microenvironment, notably visceral adipose, secreted Wnt5a. Conditional knockout host WNT5A significantly reduced metastatic burden. Tumors formed mice had elevated cytotoxic T cells, increased...
Abstract Background The majority of women with epithelial ovarian cancer (OvCa) are diagnosed metastatic disease, resulting in a poor 5-year survival 31%. Obesity is recognized non-infectious pandemic that increases OvCa incidence, enhances success and reduces survival. We have previously demonstrated link between obesity diet-induced mouse model wherein significantly enhanced tumor burden was associated decreased M1/M2 tumor-associated macrophage ratio ( Liu Y et al . Can, Res. 2015;...
Ovarian cancer, the most deadly gynecological malignancy in U.S. women, metastasizes uniquely, spreading through peritoneal cavity and often generating widespread metastatic sites before diagnosis. The vast majority of ovarian cancer cases occur women over 40 median age at diagnosis is 63. Additionally, elderly receive poorer prognoses when diagnosed with cancer. Despite being a significant risk factor for development this there are little published data which address impact aging on...
Mesothelin (MSLN), a glycoprotein normally expressed by mesothelial cells, is overexpressed in ovarian cancer (OvCa) suggesting role tumor progression, although the biological function not fully understood. OvCa has high mortality rate due to diagnosis at advanced stage disease with intraperitoneal metastasis. Tumor cells detach from primary as single or multicellular aggregates (MCAs) and attach mesothelium of organs within peritoneal cavity producing widely disseminated secondary lesions....
Abstract The ability to identify robust genomic signatures that predict response immune checkpoint blockade is restricted by limited sample sizes and ungeneralizable performance across cohorts. To address these challenges, we established Cancer-Immu (http://bioinfo.vanderbilt.edu/database/Cancer-Immu/), a comprehensive platform integrates large-scale multidimensional omics data, including genetic, bulk, single-cell transcriptomic, proteomic, dynamic profiles, with clinical phenotypes explore...
Membrane type 1 matrix metalloproteinase (MT1-MMP, MMP-14) is a transmembrane collagenase highly expressed in metastatic ovarian cancer and correlates with poor survival. Accumulating evidence shows that the cytoplasmic tail of MT1-MMP subjected to phosphorylation, this post-translational modification regulates enzymatic activity at cell surface. To investigate potential role residue Thr567 phosphorylation regulation metastasis-associated behaviors, cells express low endogenous levels were...
Abstract Background Metarhizium anisopliae , a soil-borne entomopathogen found worldwide, is an interesting fungus for biological control. However, its efficacy in the fields significantly affected by environmental conditions, particularly moisture. To overcome weakness of and determine isolates with antistress capacity, efficacies four M. isolates, which were collected from arid regions Yunnan Province China during dry season, determined at different moisture levels, isolate MAX-2...
Damage of double stranded (ds) DNA by metabolites lipophilic pollutants and drugs constitutes a major toxicity pathway. We evaluated films poly(dimethyldiallylammonium chloride) (PDDA) grown layer-by-layer on pyrolytic graphite electrodes for the detection damage model metabolite styrene oxide, which forms chemical adducts with bases. The method features electroactive probe Co(bpy)33+, binds to as outer layer [(PDDA/ds-DNA)2] in greater amounts when ds-DNA is intact than it damaged....
Abstract Epithelial ovarian cancer (EOC) metastasis occurs by exfoliation of cells and multicellular aggregates (MCAs) from the tumor into peritoneal cavity, adhesion to retraction mesothelial subsequent anchoring. Elevated levels lysophosphatidic acid (LPA) have been linked aberrant cell proliferation, oncogenesis, metastasis. LPA disrupts junctional integrity epithelial cohesion in vitro however, fate free-floating cells/MCAs response host tissues remain unclear. EOC MCAs displayed...
Age is the most significant risk factor for ovarian cancer (OvCa), deadliest gynecologic malignancy. Metastasizing OvCa cells adhere to omentum, a peritoneal structure rich in collagen, adipocytes, and immune cells. Ultrastructural changes omentum omental collagen matrix with aging have not been evaluated.
Pseudoaneurysm is a rare but lethal complication of acute myocardial infarction. In this study, we present unique case patient with left ventricular free wall rupture detected by cardiac magnetic resonance more than 1 year after percutaneous transluminal coronary intervention.