A5100620931- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Adipose Tissue and Metabolism
- Glaucoma and retinal disorders
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Acupuncture Treatment Research Studies
- Autophagy in Disease and Therapy
- Virus-based gene therapy research
- interferon and immune responses
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Mitochondrial Function and Pathology
- Vector-Borne Animal Diseases
- Exercise and Physiological Responses
- Ocular Surface and Contact Lens
- Cytomegalovirus and herpesvirus research
- Cell Adhesion Molecules Research
- Virology and Viral Diseases
- Plant Virus Research Studies
- Viral Infections and Immunology Research
- Physical Activity and Health
- Corneal surgery and disorders
- Facial Rejuvenation and Surgery Techniques
- Pancreatitis Pathology and Treatment
Shanxi Agricultural University
2004-2025
Zhejiang Yongning Pharma (China)
2025
Sun Yat-sen University
2022-2024
Sun Yat-sen Memorial Hospital
2022-2024
Beijing Sport University
2008-2024
Jinan University
2024
Central Hospital of Zibo
2024
General Administration of Sport of China
2024
Bridge University
2023
Fudan University
2023
Background:The application of chimeric antigen receptor (CAR) NK cells in solid tumors is hindered by lack tumor-specific targets and inefficient CAR cell efficacy.It has been reported that mesothelin (MSLN) may be an ideal immunotherapy target for gastric cancer.However, the feasibility using anti-MSLN to treat cancer remains studied.Methods: MSLN expression primary human cancer, normal tissues lines were detected.MSLN CD19 targeted NK-92 (MSLN-and CD19-CAR NK) constructed, purified...
The emergence of the PB2 E627K substitution is critical in mammalian adaptation and pathogenesis AIV. H7N9 AIVs that emerged 2013 possess a prominent ability gaining mutation humans. Here, we demonstrate acquisition driven by low polymerase activity conferred viral PA protein human cells, four residues are collectively involved this process. Notably, leads to significant dependence function on ANP32A protein, Anp32a knockout abolishes mice. These findings reveal host crucial for during
Wild birds and waterfowl serve as the natural reservoirs of avian influenza viruses (AIVs). When AIVs originating from wild cross species barriers to infect mammals or humans, they pose a significant threat public health. The H12 subtype primarily circulates in birds, with relatively few isolates reported worldwide, evolutionary biological characteristics remain largely unknown. In this study, we analyzed spatiotemporal distribution worldwide conducted comprehensive investigation into an...
In this paper, Sedum yongkangense is described as a new species based on morphological and molecular analyses, its taxonomic relationships are discussed. Morphological analysis indicates S. should be classified in the genus L. sect. distinct from related ryukyuense, mukojimense boninense having morphology of biennial life form; spreading cymes with numerous flowers; unequal, linear, terete sepals; horizontally follicles; an inland habitat. Molecular sequences nuclear ribosomal internal...
Numerous protocols for viral enrichment and genome amplification have been created. However, the direct identification of genomes from clinical specimens using next-generation sequencing (NGS) still has its challenges. As a selected nucleic acid extraction method may determine sensitivity reliability NGS, it is valuable to evaluate efficiency different kits directly. In this study, we performed qRT-PCR metagenomic analysis four commonly used Qiagen kits: QIAamp Viral RNA Mini Kit (VRMK),...
Influenza A virus (IAV) matrix protein 2 (M2) plays multiple roles in the early and late phases of viral infection. Once synthesized, M2 is translocated to endoplasmic reticulum (ER), travels Golgi apparatus, sorted at trans-Golgi network (TGN) for transport apical plasma membrane, where it functions budding. We hypothesized that trafficking along with its secretory pathway must be finely regulated, host factors could involved this process. However, no studies examining role...
According to the requirements of Ministry Agriculture China, all vaccines must be screened for exogenous virus contamination before commercialization. A freeze-dried vaccine against Marek's disease was used inoculate specific pathogen-free chickens, from which serum samples were collected after 42 days. The results positive reticuloendotheliosis antibody, indicative contamination. After neutralization with virus, chicken embryo fibroblasts inoculated vaccine. Afterward, viral isolation and...
Posttranslational modifications, such as SUMOylation, play specific roles in the life cycle of invading pathogens. However, effect SUMOylation on adaptation, pathogenesis, and transmission influenza A virus (IAV) remains largely unknown. Here, we found that a conserved lysine residue at position 612 (K612) polymerase basic protein 1 (PB1) IAV is bona fide site. PB1 K612 had no stability or cellular localization PB1, but was critical for viral ribonucleoprotein (vRNP) complex activity...
SGLT-2 inhibitors, such as empagliflozin, have been shown to reduce the occurrence of cardiovascular events and delay progression atherosclerosis. However, its role in atherosclerotic calcification remains unclear. In this research, ApoE-/- mice were fed with western diet empagliflozin was added drinking water for 24 weeks. Empagliflozin treatment significantly alleviated arterial assessed by alizarin red von kossa staining aortic roots reduced lipid levels, while had little effect on body...
The H9N2 subtype of avian influenza virus (AIV) is widely prevalent in poultry and wild birds globally, has become the predominant circulating China. AIV can directly or indirectly (by serving as a "donor virus") infect humans, posing significant threat to public health. Currently, there lack in-depth research on prevalence viruses Shanxi Province, central In this study, we isolated 14 AIVs from October 2020 April 2022 genetic analysis revealed that these belonged seven different genotypes....
The objective of this paper was to study the incidence, risk factors, clinical outcome, management and prevention pure red cell aplasia (PRCA) following major ABO-incompatible allogeneic hematopoietic stem transplantation (allo-HSCT). We retrospectively analyzed 11 cases PRCA from a series 42 patients undergoing allo-HSCT April 1997 December 2005. Eleven out developed (26.1%). All were in blood group O recipients grafts A donor (n = 9) or B 2). factors associated with an increased PRCA: (1)...
Proliferation and migration of retinal pigment epithelial (RPE) cells play a crucial role in proliferative vitreoretinopathy (PVR)-related pathology. Cytokines, including EGF, can result RPE cell activation cause PVR. In this study, integrin-α<sub>5</sub> expression was first studied PVR membranes by immunofluorescence. Then the effect EGF on determined flow cytometry, Western blot analysis reverse-transcription polymerase chain reaction (RT-PCR) ARPE-19 line. were measured...
Peste des petits ruminants (PPR) is an acute, febrile, viral disease of small that has a significant economic impact. For many diseases, vaccination with virus-like particles (VLPs) shown considerable promise as prophylactic approach; however, the processes assembly and release peste virus (PPRV) VLPs are not well characterized, their immunogenicity in host unknown. In this study, PPRV were generated baculovirus system through simultaneous expression matrix (M) protein hemaglutin (H) or...
Trichomicin, a novel small-molecule compound isolated from the fungus Trichoderma harzianum and identified as new structure compound, exhibited antitumor activities in various human cancer cell lines reversed drug resistance activity multidrug-resistant line KBV. The underlying cellular molecular mechanism was illuminated. Trichomicin can significantly induce apoptosis reduced IL-6 expression phosphorylation of STAT3 were found response to treatment. blockade mediated JAK-STAT3 signaling...