A5004945977- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Advanced X-ray and CT Imaging
- Cancer Mechanisms and Therapy
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Renal cell carcinoma treatment
- Monoclonal and Polyclonal Antibodies Research
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Advancements in Semiconductor Devices and Circuit Design
- Radiomics and Machine Learning in Medical Imaging
- Tissue Engineering and Regenerative Medicine
- Neuroblastoma Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Protein Degradation and Inhibitors
- Extracellular vesicles in disease
- Nanowire Synthesis and Applications
- Protein purification and stability
Indiana University Bloomington
2025
Indiana University School of Medicine
2024-2025
Guangzhou Medical University
2017-2025
Southern Medical University
2024-2025
Guangdong Provincial People's Hospital
2024-2025
Guangdong Academy of Medical Sciences
2024-2025
Second Affiliated Hospital of Guangzhou Medical University
2017-2024
Indiana University
2024
Hubei University of Medicine
2024
To investigate the efficacy and safety of transarterial chemoembolization (TACE) combined with lenvatinib plus PD-1 inhibitor (TACE-L-P) versus TACE (TACE-L) for patients advanced hepatocellular carcinoma (HCC).Data HCC treated TACE-L-P (TACE-L-P group) or TACE-L (TACE-L from January 2019 to December 2020 were prospectively collected retrospectively analyzed. The differences in overall survival (OS), progression-free (PFS), tumor responses (based on modified Response Evaluation Criteria...
The complex immunosuppressive tumour microenvironment (TME) and lack of tumour-specific targets hinder the application chimeric antigen receptor (CAR) T cells in treatment solid tumours. Combining local with CAR cell immunotherapy may regulate TME enhance killing potency Here, we show that AXL, which is highly expressed non-small lung cancer (NSCLC) but not normal tissues, might be a target for therapy. AXL-CAR alone cause moderate regression subcutaneous pulmonary metastatic cell-derived...
Glioblastoma (GBM) is the most lethal brain cancer, with GBM stem cells (GSCs) driving therapeutic resistance and recurrence. Targeting GSCs offers a promising strategy for preventing tumor relapse improving outcomes. We identify SUV39H1, histone-3, lysine-9 methyltransferase, as critical GSC maintenance progression. SUV39H1 upregulated in compared normal tissues, single-cell RNA-seq showing its expression predominantly due to super-enhancer-mediated activation. Knockdown of impaired their...
Abstract Background B7-H3, an immune-checkpoint molecule and a transmembrane protein, is overexpressed in non-small cell lung cancer (NSCLC), making it attractive therapeutic target. Here, we aimed to systematically evaluate the value of B7-H3 as target NSCLC via T cells expressing B7-H3-specific chimeric antigen receptors (CARs) bispecific killer engager (BiKE)-redirected natural (NK) cells. Methods We generated CAR B7-H3/CD16 BiKE derived from anti-B7-H3 antibody omburtamab that has been...
Abstract Cucurbitacin B (CuB) is a widely available triterpenoid molecule that exhibits various biological activities. Previous studies on the anti-tumour mechanism of CuB have mostly focused cell apoptosis, and research ferroptosis-inducing effect has rarely been reported. Herein, we first discovered excellent cytotoxicity towards human nasopharyngeal carcinoma cells elucidated its potential mechanisms. Morphology alterations mitochondrial ultrastructure, as observed via transmission...
Background:The application of chimeric antigen receptor (CAR) NK cells in solid tumors is hindered by lack tumor-specific targets and inefficient CAR cell efficacy.It has been reported that mesothelin (MSLN) may be an ideal immunotherapy target for gastric cancer.However, the feasibility using anti-MSLN to treat cancer remains studied.Methods: MSLN expression primary human cancer, normal tissues lines were detected.MSLN CD19 targeted NK-92 (MSLN-and CD19-CAR NK) constructed, purified...
Abstract Small cell lung cancer (SCLC) is characterized by a high relapse rate, drug tolerance, and limited treatment choices. Chimeric antigen receptor (CAR)-modified NK cells represent promising immunotherapeutic modality for treatment. However, their potential applications have not been explored in SCLC. Delta-like ligand 3 (DLL3) has reported to be overexpressed SCLC may rational target CAR immunotherapy. In this study, we developed DLL3-specific NK-92 the of A coculture DLL3+ lines with...
Abstract Background & Aims Our retrospective study has suggested encouraging outcomes of lenvatinib combined with PD‐1 inhibitor and transarterial chemoembolization (TACE) on advanced hepatocellular carcinoma (HCC). This phase II trial was conducted to prospectively investigate the efficacy safety lenvatinib, sintilimab (a inhibitor) plus TACE (Len‐Sin‐TACE) in patients stage HCC. Methods a single‐arm trial. Patients BCLC C HCC were recruited. They received (bodyweight ≥60 kg, 12 mg;...
Chimeric antigen receptor (CAR)-modified natural killer (NK) cell therapy represents a kind of promising anti-cancer treatment because CAR renders NK cells activation and recognition specificity toward tumor cells. An immune checkpoint molecule, B7-H3, plays an inhibitory role in modulation To enhance functions, we generated NK-92MI carrying anti-B7-H3 by lentiviral transduction. The expression significantly enhanced the cytotoxicity against B7-H3-positive In accordance with cytotoxicity,...
Osteosarcoma, a predominant malignant tumor among adolescents, exhibits high mortality and suboptimal immunotherapy efficacy due to collagen-dense extracellular matrix (ECM) that hinders cytotoxic T lymphocyte (CTL) infiltration. Herein, we developed mesoporous polydopamine (MPDA) nanoparticles encapsulating bromelain the immune adjuvant R848 (M@B/R), aimed at enhancing photothermal immunotherapy. These efficiently accumulate site following injection. Upon near-infrared (NIR) light...
Background:The application of chimeric antigen receptor (CAR) NK cells in solid tumors is hindered by lack tumor-specific targets and inefficient CAR-NK cell efficacy.Claudin-6 (CLDN6) has been reported to be overexpressed ovarian cancer may an attractive target for immunotherapy.However, the feasibility using anti-CLDN6 treat remains explored.Methods: CLDN6 expression primary human cancer, normal tissues lines were detected immunohistochemistry western blot.Two types third-generation CAR...
Microwave ablation (MWA) triggers a weak systemic immune response that leads to the abscopal regression of distant metastases while killing local tumors, known as effect. Combining MWA with chimeric antigen receptor (CAR)-T cells demonstrates promise in enhancing effect antigen-homogeneous tumors. However, loss recognized by CAR or intrinsic antigenic heterogeneity solid tumors poses major obstacle. SIRPα variant (CV1)-secreting CAR-T (sCAR-T) elicit an on mice receiving MWA....
Abstract Hepatocellular carcinoma (HCC) is a highly malignant tumor characterized by insidious onset and rapid progression, with limited treatment choices. One modality, chimeric antigen receptor (CAR)-modified natural killer (NK) cell immunotherapy, has shown promise for various cancers. However, the efficacy of CAR-NK cells HCC remain inferior. In this study, we developed two glypican-3 (GPC3)-specific CAR-NK-92 lines (GPC3-CAR-NK) explored their antitumor HCC. Significant levels cytokine...
Abstract Human epidermal growth factor receptor 2 (HER2) is highly overexpressed on the surface of breast cancer cells, presenting an attractive target for therapeutic antibodies. Antibody-dependent cellular cytotoxicity (ADCC) a central mechanism underlying antitumor activities anti-HER2 monoclonal Here, we engineered Ab5, germline-like antibody derived from naïve human library. Our aim was to enhance ADCC properties Ab5 by affinity maturation. Through in silico aided mutagenesis analysis,...
Abstract Purpose To investigate the efficacy and safety of tyrosine-kinase inhibitor (TKI) combined with iodine-125 seed brachytherapy (TKI-I) versus TKI alone for patients hepatocellular carcinoma (HCC) refractory to transarterial chemoembolization (TACE). Methods Data TACE-refractory HCC who received (sorafenib or lenvatinib) TKI-I from September 2018 December 2020 were retrospectively analyzed. A propensity score matching (PSM) was performed diminish potential bias. The primary endpoints...
Abstract Of the more than 100 types of brain cancer, glioblastoma (GBM) is deadliest. As GBM stem cells (GSCs) are considered to be responsible for therapeutic resistance and tumor recurrence, effective targeting elimination GSCs could hold promise preventing recurrence achieving potential cures. We show here that SUV39H1 , which encodes a histone-3, lysine-9 methyltransferase, plays critical role in GSC maintenance progression. Upregulation was observed samples compared normal tissues,...
Abstract To assess the efficacy, safety, and feasibility of a separate inserted positioning fine needle-mediated breathing-control technique applied to computed tomography (CT)-guided percutaneous puncture for biopsy or microwave ablation (MWA) small lung/liver nodules near diaphragm. Total 46 patients with pulmonary/liver (≤ 3 cm in size) diaphragm(nodule within 1 distance diaphragm)were undergone ( n = 15) MWA (n 31) under guidance CT, was precise punctures. CT plain scan performed monitor...
Abstract Purpose To investigate the efficacy and safety of transarterial chemoembolization (TACE) combined with lenvatinib plus PD-1 inhibitor (TACE-L-P) versus TACE (TACE-L) for patients advanced hepatocellular carcinoma (HCC). Methods Data HCC treated TACE-L-P or TACE-L from January 2019 to December 2020 were retrospectively analyzed. The differences in overall survival (OS), progression-free (PFS), tumor responses (based on modified Response Evaluation Criteria Solid Tumors) adverse...
To propose an imaging protocol that provides satisfactory image quality for oral examination while minimizing radiation dosage using 320-slice multidetector CT (MDCT).An anthropomorphic head phantom was scanned 320 MDCT with protocols combining different scanning modes: volume (whole or local) vs helical (80- 64-slice detectors); tube voltage settings (80 kVp, 120 kVp and 135 kVp); current (60 mA, 80 100 mA mA). A total of six anatomical bone structures three soft-tissue were assessed...