A5051907319- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Cardiac Arrest and Resuscitation
- Hematological disorders and diagnostics
- Transplantation: Methods and Outcomes
- Pluripotent Stem Cells Research
- Intensive Care Unit Cognitive Disorders
- Neonatal and Maternal Infections
- 3D Printing in Biomedical Research
- Atherosclerosis and Cardiovascular Diseases
- Hemodynamic Monitoring and Therapy
- Nosocomial Infections in ICU
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bacterial Infections and Vaccines
- Poisoning and overdose treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neuroscience and Neural Engineering
- Chemokine receptors and signaling
- Methemoglobinemia and Tumor Lysis Syndrome
- Metabolism and Genetic Disorders
China Three Gorges University
2025
Shanghai Children's Medical Center
2016-2025
Shanghai Jiao Tong University
2019-2025
Guilin University of Electronic Technology
2025
Yichang Central People's Hospital
2025
First Affiliated Hospital of Chengdu Medical College
2020-2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
Guangdong Academy of Medical Sciences
2024
Huazhong University of Science and Technology
2007-2023
The potential use of induced pluripotent stem cells (iPSCs) in personalized regenerative medicine applications may be augmented by transgenics, including the expression constitutive cell labels, differentiation reporters, or modulators disease phenotypes. Thus, there is precedence for reproducible transgene amongst iPSC sub-clones with isogenic diverse genetic backgrounds. Using virus transposon vectors, integration sites and copy numbers are difficult to control, nearly impossible reproduce...
Ferroptosis, a recently discovered form of regulated cell death that is characterized by iron accumulation and excessive reactive oxygen species generation, has been favored most researchers. Increasing evidence suggest ferulic acid (FA) could exert marked effects to myocardial ischemia reperfusion (I/R) injury, although the understanding its molecular mechanism still limited. In our study, I/R injury model was established explore relationship between ferroptosis. First, we successfully...
Aortic dissection is rare in both children and adults. Misdiagnosis common because of hidden symptoms, insufficient knowledge among pediatricians, lack consensus guidelines. We aimed to report the clinical features patients enhance diagnostic awareness aortic with acute chest pain or trauma, avoid delayed diagnosis subsequent worsening outcomes. presented three cases pediatric summarized our findings from literature. treated a 13-year-old boy Stanford Type A dissection, 9-year-old B an...
ABSTRACT Background and Aims The COVID‐19 pandemic has profoundly impacted the transmission dynamics epidemiology of respiratory pathogens, primarily due to non‐pharmaceutical interventions (NPIs). This study aims evaluate effects NPIs on characteristics winter pathogens. Methods involved collection pathogen test results from all patients tested at our hospital during two distinct periods: September 2021 May 2022 2023. comparison positive rates was performed using χ 2 test. A p ‐value less...
The authors declare no conflicts of interest. data that support the findings this study are available from corresponding author upon reasonable request.
This study aimed to evaluate the clinical validity of Pediatric Assessment Triangle (PAT) in a pediatric emergency department (PED). We conducted retrospective analysis 799 children who visited our PED and collected data on age, sex, disease severity, expense, disposition. analyzed correlations between PAT disease, waiting time, disposition, cost. In total, 429 boys (53.7%) 370 girls (46.3%), with an average age 4.97 years, were enrolled. The number levels 2, 3, 4 was 5 (0.6%), 158 (19.8%),...
Background The respiratory syncytial virus (RSV) is the main cause of bronchiolitis in infants and interferon (IFN) α a commercial antiviral drug. nebulization IFN α1b could be viable treatment method. In this study, therapeutic effects safety delivery via infant were investigated multi-center prospective study. Methods findings Bronchiolitis patients admitted to 22 hospitals who met inclusion criteria enrolled randomly allocated four groups: control, Intramuscular Injection, Nebulization 1...
The purpose of this article was to establish and validate clinically applicable septic shock early warning model (SSEW model) that can identify in hospitalized children with onco-hematological malignancies accompanied fever or neutropenia.
To investigated the clinical efficacy of Soluble thrombomodulin (sTM), tissue plasminogen activator inhibitor complex (t-PAI·C),thrombin-antithrombin (TAT),α2-plasmininhibitor-plasmin (PIC) in pediatric sepsis and pediatrics sepsis-induced coagulopathy (pSIC).We prospectively collected patient data with diagnosed PICU Shanghai Children's Medical Center from June 2019 to 2021. sTM,t-PAI·C, TAT,PIC classical coagulation laboratory tests (CCTs) were evaluated on day diagnosis.Fifty-nine...
In China, pertussis is a major health problem with an increasing incidence despite immunization efforts. Timely and accurate diagnosis essential for the optimal management of pertussis, especially in severe cases.Nasopharyngeal swabs or sputum specimens were obtained from patients suspected having on day hospitalization at Shanghai Children's Medical Center December 01, 2016, to November 30, 2017. The tested FilmArray Respiratory Panel, multiplex polymerase chain reaction (PCR) assay that...
Background: Heart failure is a prevalent and life-threatening medical condition characterized by abnormal atrial electrical activity, contributing to higher risk of ischemic stroke. Atrial remodelling, driven oxidative stress structural changes, plays central role in heart progression. Recent studies suggest that HACE1, regulatory gene, may be involved cardiac protection against failure. Methods: Clinical data analysis patients, while an animal model utilized C57BL/6J mice. RT-PCR,...
Conventional cell handling and sorting methods require manual labor, which decreases both quality quantity. To purify adherent cultured cells, purification technologies that are high throughput without dissociation can be utilized in an on-demand manner expected. Here, we developed a Laser-induced, Light-responsive-polymer-Activated, Cell Killing (LiLACK) system enables high-speed sectioning purification. This employs visible laser beam, does not kill cells directly, but induces local heat...
To investigate the difference in positive end-expiratory pressure (PEEP) selected with chest electrical impedance tomography (EIT) and global dynamic respiratory system compliance (Crs) moderate-to-severe pediatric acute distress syndrome (pARDS).Patients pARDS (PaO2/FiO2 < 200 mmHg) were retrospectively included. On day of diagnosis, two PEEP levels determined during decremental titration for each individual using best (PEEPC) EIT-based regional (PEEPEIT) methods. The differences (for both...
So far, there is no efficient treatment for pulmonary fibrosis. The objective of this study was to determine whether intramuscular injection the hepatocyte growth factor (HGF) plasmid DNA by in vivo electroporation could prevent bleomycin-induced fibrosis rats, and investigate possible mechanisms.Twenty male Wistar rats were randomly divided into four groups: control group (group C), model M), early intervention I) late II). Groups M, I II intratracheally infused with bleomycin, then...