A5103023712- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Metal complexes synthesis and properties
- Growth Hormone and Insulin-like Growth Factors
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hemostasis and retained surgical items
- Chronic Myeloid Leukemia Treatments
- Hip disorders and treatments
- Ferrocene Chemistry and Applications
- Blood properties and coagulation
- Orthopaedic implants and arthroplasty
- Rheumatoid Arthritis Research and Therapies
- Bone and Joint Diseases
- Porphyrin and Phthalocyanine Chemistry
- Osteoarthritis Treatment and Mechanisms
- Photodynamic Therapy Research Studies
- Orthopedic Infections and Treatments
- Colorectal Cancer Surgical Treatments
- Musculoskeletal synovial abnormalities and treatments
- Diverticular Disease and Complications
- Colorectal and Anal Carcinomas
- Advanced Photocatalysis Techniques
- Axon Guidance and Neuronal Signaling
- TiO2 Photocatalysis and Solar Cells
Kansai Medical University
1974-2025
Tenri Health Care University
2018-2025
Tenri University
2019-2025
Osaka Metropolitan University
2023-2024
Kyoto University
1997-2024
University of Miyazaki
2012-2024
Takano Hospital
2024
RIKEN Center for Sustainable Resource Science
2017-2023
Asahi General Hospital
2023
Medtronic (Japan)
2023
Indirect immunofluorescence of certain human sera demonstrated an antigen(s) in the cytoplasm 1--5% cells a T-cell line, MT-1, from patient with adult leukemia (ATL), which is endemic southwestern Japan. The antigen was not detected other lymphoid cell lines, including six seven B-cell and four non-T non-B lines. did show cross antigenicity that herpesviruses, Epstein--Barr virus, herpes simplex cytomegalovirus, varicella-zoster herpesvirus saimiri, Marek disease virus. proportion...
The potential use of induced pluripotent stem cells (iPSCs) in personalized regenerative medicine applications may be augmented by transgenics, including the expression constitutive cell labels, differentiation reporters, or modulators disease phenotypes. Thus, there is precedence for reproducible transgene amongst iPSC sub-clones with isogenic diverse genetic backgrounds. Using virus transposon vectors, integration sites and copy numbers are difficult to control, nearly impossible reproduce...
Gene-edited induced pluripotent stem cells (iPSCs) provide relevant isogenic human disease models in patient-specific or healthy genetic backgrounds. Towards this end, gene targeting using antibiotic selection along with engineered point mutations remains a reliable method to enrich edited cells. Nevertheless, integrated markers obstruct scarless transgene-free editing. Here, we present for marker excision microhomology-mediated end joining (MMEJ). By overlapping the homology arms of...
Summary The lower detection limit of the conventional one-stage aPTT based clotting assay for determining FVIII:C levels is generally 1.0-2.0 IU/dl. Consequently, it has been impossible to study clinical significance less than 1.0 Using a photo-optical automated coagulation analyzer, Organon Teknika MDA II®, we have performed qualitative and quantitative waveform analysis measured by in 36 severely affected Hemophilia A patients. Qualitative showed clear evidence individual differences...
summary Normal haemostasis is maintained by a controlled balance between coagulation and fibrinolysis, involving thrombin plasmin the respective key enzymes. Simultaneous evaluation of both enzymes facilitates, therefore, an overall understanding normal pathological haemostasis. Combined generation (T/P-G) assays have been recently described, we adapted technique to investigate interplay fibrinolysis in patients with various haemostatic disorders. Our modified T/P-G was initiated addition...
Summary. We report a case of haemophilia A with high responding inhibitor factor VIII (FVIII) who had serious retroperitoneal haematoma caused by penetration duodenal ulcer. Inhibitor‐bypassing therapy was commenced immediately on admission. On the 17th day treatment activated prothrombin complex concentrate (APCC; FEIBA®), re‐bleeding occurred and thrombelastography (TEG) demonstrated resistance to therapy. Treatment changed recombinant VII (rFVIIa; NovoSeven®) resulted in clinical...
The development of mossy-fibre projecting precerebellar neurons (PCN) presents a classical example tangential neuronal migration. PCN migrate tangentially along marginal streams beneath the pial surface from lower rhombic lip to specific locations in hindbrain, where they form nuclei. Among them, pontine follow stereotypic anteroventral-directed pathway nuclei pons. guidance mechanisms that determine migration and anterior are poorly understood. Here, we report chemokine SDF1 (also known as...
Introduction A recently developed method to assess comprehensive coagulation function, clot waveform analysis ( CWA ), accurately detect low levels (<1 IU/dL) of factor VIII activity (FVIII:C) in haemophilia patients (HA‐pts). Improvements are needed, however, differentiate with very from absent FVIII :C. Aim We attempted optimize using the analyser CS ‐2000i™ distinguish between and :C severe HA ‐pts. Methods Results Activated partial thrombin time aPTT )‐based waveforms were determined...
Although the rat intraovarian insulin-like growth factor I (IGF-I) system is well documented, increasing availability of null mouse mutants for components IGF necessitates characterization model as well. Therefore, we undertook to define IGF-I and examine its operational characteristics. The cellular pattern ovarian gene expression was comparable in immature type receptor. In both species, messenger RNA (mRNA) selectively expressed by granulosa cells growing, healthy appearing follicles....