A5036194455- TGF-β signaling in diseases
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- Liver physiology and pathology
- Renal and related cancers
- Renal and Vascular Pathologies
- Dialysis and Renal Disease Management
- Liver Diseases and Immunity
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Organ Donation and Transplantation
- IgG4-Related and Inflammatory Diseases
- Surfactants and Colloidal Systems
- Hepatocellular Carcinoma Treatment and Prognosis
- Parathyroid Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Urologic and reproductive health conditions
- Organ Transplantation Techniques and Outcomes
- Electrostatics and Colloid Interactions
- Renal Transplantation Outcomes and Treatments
- Genetic factors in colorectal cancer
- Bladder and Urothelial Cancer Treatments
- Neuroendocrine Tumor Research Advances
- Urinary Bladder and Prostate Research
- Gastrointestinal disorders and treatments
Kansai Medical University
2014-2024
Nara Medical University
2010-2021
Japan Society for the Promotion of Science
2013
Nara Medical University Hospital
2006-2012
University of California, Davis
2008-2011
National Center For Child Health and Development
2010
Center for HIV and Hepatogastroenterology
2007-2009
Showa University Hospital
2009
Science Research Laboratory
2004
Osaka University
1997-2001
Abstract Many patients with chronic hepatitis caused by C virus (HCV) infection develop liver fibrosis high risk for hepatocellular carcinoma (HCC), but the mechanism underling this process is unclear. Conversely, transforming growth factor beta (TGF-β) activates not only TGF-β type I receptor (TβRI) also c-Jun N-terminal kinase (JNK), which convert mediator Smad3 into two distinctive phosphoisoforms: C-terminally phosphorylated (pSmad3C) and linker-phosphorylated (pSmad3L). Whereas...
Hepatic stellate cells (HSCs) spontaneously transdifferentiate into myofibroblast (MFB)–phenotype on plastic dishes. This response recapitulates the features of activation in vivo. Transforming growth factor β (TGF–β) plays a prominent role stimulating liver fibrogenesis by MFBs. In quiescent HSCs, TGF–β signaling involves type I receptor (TβRI)–mediated phosphorylation serine residues within conserved SSXS motif at C–terminus Smad2 and Smad3. The middle linker regions Smad3 also are...
There have been important advances in defining effector mechanisms for several human autoimmune diseases. However, most diseases, the induction stage is less well defined and there are very few clues on etiology. Our laboratory has focused molecular basis of autoantibody recognition epitope modification primary biliary cirrhosis (PBC). work demonstrated that antibodies to mitochondria, hallmark disease, directed against a conserved site pyruvate dehydrogenase, E2 subunit dehydrogenase...
Hepatitis B virus X (HBx) protein is suspected to participate in oncogenesis during chronic hepatitis progression. Transforming growth factor beta (TGF-beta) signaling involves both tumor suppression and oncogenesis. TGF-beta activates type I receptor (TbetaRI) c-Jun N-terminal kinase (JNK), which differentially phosphorylate the mediator Smad3 become C-terminally phosphorylated (pSmad3C) linker-phosphorylated (pSmad3L). Reversible shifting of Smad3-mediated between HBx-expressing...
Abstract The aim of this study was to determine the safety and potential efficacy B-cell depletion with anti-CD20 monoclonal antibody rituximab in patients primary biliary cirrhosis (PBC) an incomplete response ursodeoxycholic acid (UDCA). This open-label enrolled six PBC responses UDCA be treated 2 doses 1000 mg separated by weeks followed for 52 weeks. endpoints were changes function. Two received only 1 dose rituximab, one due activation latent varicella other a viral upper respiratory...
Current evidence suggests that regulation of extracellular matrix (ECM) accumulation by fibrogenic TGF-β and PDGF signals involves different mechanisms in acute chronic liver injuries, even though hepatic stellate cells (HSC) are the principal effecter both cases. As a result damage, HSC undergo progressive activation to become myofibroblasts (MFB)-like cells. Our current review will discuss differential signaling between MFB vitro vivo. Smad proteins, which convey from receptors nucleus,...
During chronic liver injury, transforming growth factor β (TGF-β) plays a prominent role in stimulating fibrogenesis by myofibroblast-like cells derived from hepatic stellate (HSCs). On the other hand, Smad 7 was recently shown to antagonize TGF-β-induced activation of signal-transducing Smads (2 and 3). In this study, we investigated regulatory mechanisms TGF-β signals rat HSCs during acute injury myofibroblasts (MFBs) focusing on roles 2 antagonistic 7. HSC-derived increased plasminogen...
Abstract Cancer cells often gain advantage by reducing the tumor-suppressive activity of transforming growth factor-β (TGF-β) together with stimulation its oncogenic as in Ras-transformed cells; however, molecular mechanisms remain largely unknown. TGF-β activates both type I receptor (TβRI) and c-Jun NH2-terminal kinase (JNK), which phosphorylate Smad2 Smad3 at COOH-terminal (pSmad2/3C) linker regions (pSmad2/3L). Here, we report that Ras transformation suppresses TβRI-mediated pSmad3C...
Abstract Transforming growth factor (TGF)-β initially inhibits of mature epithelial cells. Later, however, autocrine TGF-β signaling acts in concert with the Ras pathway to induce a proliferative and invasive phenotype. activates not only type I receptor (TβRI) but also Ras-associated kinases, which differentially phosphorylate mediators Smad2 Smad3 create distinct phosphorylated forms: COOH-terminally Smad2/3 (pSmad2C pSmad3C) both linker (pSmad2L/C pSmad3L/C). In this study, we...
Abstract Our laboratory has reported that mice express a dominant negative form of transforming growth factor β receptor restricted to T cells (dnTGFβRII) develop an inflammatory biliary ductular disease with elevated serum levels interleukin (IL)-12p40 and other proinflammatory cytokines antimitochondrial autoantibodies (AMAs) closely resembling human primary cirrhosis (PBC). We have used this mouse model address the potential mechanisms immunomodulation liver by creating two unique genetic...
Abstract The stabilityof vitamin A was studied in thee different emulsions: oil‐in‐water (O/W), water‐in‐oil (W/O), and oil‐in‐water‐in‐oil (O/W/O). stability of retinol (vitamin alcohol) the O/W/O emulsion highest among types emulsions; remaining percentages at 50°C after 4 wk O/W/O, W/O, O/W emulsions were 56.9, 45.7, 32.3, respectively. With increasing peroxide value W/O emulsifiers, percentage palmitate decreased significantly, indicating that peroxides formulae accelerate decomposition...
Conversion of normal epithelial cells to tumors is associated with a shift in transforming growth factor-beta (TGF-beta) function: reduction tumor suppressor activity and increase oncogenic activity. However, specific mechanisms this functional alteration during human colorectal carcinogenesis remain be elucidated. TGF-beta signaling involves Smad2/3 phosphorylated at linker regions (pSmad2/3L) COOH-terminal (pSmad2/3C). Using antibodies each phosphorylation site, we herein showed that Smad2...
Summary Our laboratory has suggested that loss of tolerance to pyruvate dehydrogenase (PDC-E2) leads an anti-mitochondrial antibody response and autoimmune cholangitis, similar human primary biliary cirrhosis (PBC). We have this can be induced either via chemical xenobiotic immunization or exposure select bacteria. work also highlighted the importance genetic susceptibility. Using non-obese diabetic (NOD) congenic strain 1101 (hereafter referred as NOD.1101 mice), which chromosome 3 regions...
To cite this article: Takeda T, Sakurai Y, Takahagi S, Kato J, Yoshida K, Yoshioka A, Hide M, Shima M. Increase of coagulation potential in chronic spontaneous urticaria. Allergy 2011; 66: 428–433. Background: The pathogenesis urticaria (CU) has recently been conceived to be associated with thrombin generation through the extrinsic pathway. However, little is known about components intrinsic pathway potentially involved. Methods: investigate whole process coagulation, both classical assays...
Summary. We report a case of haemophilia A with high responding inhibitor factor VIII (FVIII) who had serious retroperitoneal haematoma caused by penetration duodenal ulcer. Inhibitor‐bypassing therapy was commenced immediately on admission. On the 17th day treatment activated prothrombin complex concentrate (APCC; FEIBA®), re‐bleeding occurred and thrombelastography (TEG) demonstrated resistance to therapy. Treatment changed recombinant VII (rFVIIa; NovoSeven®) resulted in clinical...
Increased nocturnal urinary volume is closely associated with nocturia. We investigated the relationship between polyuria and variation of body fluid distribution during daytime using bioelectric impedance analysis.A total 34 men older than 60 years were enrolled in this study. A frequency chart was recorded. Nocturnal defined as a urine per 24-hour production greater 0.35 (the index). Bioelectric analysis performed 4 times daily at 8 11 a.m., 5 9 p.m. an InBody S20 composition analyzer...
Abstract A stable formula using oil‐in‐water‐in‐oil (O/W/O) type multiple emulsions was investigated. The components consisted of hydrophilic nonionic surfactant (HCO‐60), organophilic montmorillonite, and lipophilic (DIS‐14). O/W/O were prepared by a double‐step procedure in which an O/W emulsion the first step, then “re‐emulsified” oil phase with montmorillonite. diameter innermost droplets decreased increasing HCO‐60 content (0.1–3%), while viscosity showed maximum at 1% HCO‐60,...