A5070298378- Concrete and Cement Materials Research
- Magnesium Oxide Properties and Applications
- Innovative concrete reinforcement materials
- Gut microbiota and health
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune cells in cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Immunotherapy and Immune Responses
- Microbial Natural Products and Biosynthesis
- Advancements in Battery Materials
- Liver physiology and pathology
- Cancer Mechanisms and Therapy
- Liver Disease Diagnosis and Treatment
- Advanced Battery Materials and Technologies
- Pancreatic and Hepatic Oncology Research
- Electromagnetic wave absorption materials
- Carbohydrate Chemistry and Synthesis
- Peroxisome Proliferator-Activated Receptors
- Grouting, Rheology, and Soil Mechanics
- Hormonal and reproductive studies
- RNA and protein synthesis mechanisms
- Peptidase Inhibition and Analysis
- Recycled Aggregate Concrete Performance
- Cancer Cells and Metastasis
Qingdao University of Technology
2021-2024
University of Missouri
2016-2023
Qingdao University of Science and Technology
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2020
Virginia Hospital Center
2020
Harry S. Truman Memorial Veterans' Hospital
2020
Nanjing Medical University
2015-2017
MUSC Hollings Cancer Center
2015-2016
Medical University of South Carolina
2015-2016
Southern Illinois University School of Medicine
2016
Abstract The interplay between western diet and gut microbiota drives the development of non-alcoholic fatty liver disease its progression to steatohepatitis. However, specific microbial metabolic mediators contributing steatohepatitis remain be identified. Here, a choline-low high-fat high-sugar diet, representing typical named CL-HFS, successfully induces male mouse with some features human disease, such as hepatic inflammation, steatosis, fibrosis. Metataxonomic metabolomic studies...
Ceramide, a sphingolipid metabolite, affects T-cell signaling, induces apoptosis of cancer cells, and slows tumor growth in mice. However, it has not been used as chemotherapeutic agent because its cell impermeability precipitation aqueous solution. We developed nanoliposome-loaded C6-ceremide (LipC6) to overcome this limitation investigated effects mice with liver tumors.Immune competent C57BL/6 received intraperitoneal injections carbon tetrachloride intra-splenic oncogenic hepatocytes. As...
Background Minimally invasive radiofrequency ablation (RFA) is used as a first-line treatment option for hepatocellular cancer (HCC) with the weaknesses of incomplete ablation, tumor recurrence, and inferior outcomes. To overcome this limitation, we proposed to develop sunitinib-RFA integrated therapy potential activating anti-HCC immune response. Methods Using our unique murine model, developed novel RFA platform modified human cardiac RF generator. Therapeutic efficacy sunitinib–RFA...
// Fei Zhang 1, * , Xiaoqiang Qi 2, Xiaoxiao Wang 3, Diyang Wei 3 Jiawei Wu 1 Lingling Feng Haiyan Cai Yugang Naiyan Zeng Ting Xu Aiwu Zhou and Ying Zheng Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty Basic Key Laboratory Cell Differentiation Apoptosis The Chinese Ministry Education, Jiao Tong University School Shanghai, China 2 Faculty Nanjing Medical University, Nanjing, Therapeutic Antibody Research Center SEU-Alphamab, Southeast These authors have...
Sex differences in spatial memory have long been observed humans, non-human primates and rodents, but the underlying cellular molecular mechanisms responsible for these remain obscure. In present study we found that adolescent male rats outperformed female 7 d 28 retention probes, not learning trials immediate Morris water maze task. Male also had larger long-term potentiation (LTP) at hippocampal temproammonic-CA1 (TA-CA1) synapses, which implicated to play a key role place field...
Graphene’s outstanding properties make it a potential material for reinforced cementitious composites. However, its shortcomings, such as easy agglomeration and poor dispersion, severely restrict application in materials. In this paper, highly dispersible graphene (TiO2-RGO) with better dispersibility compared oxide (GO) is obtained through improvement of the preparation method. study, both GO TiO2-RGO can improve pore size distribution cement mortars. According to results mercury intrusion...
The release of hormones from thyroxine-binding globulin (TBG) and corticosteroid-binding (CBG) is regulated by movement the reactive center loop in out β-sheet A molecule. To investigate how these changes are transmitted to hormone-binding site, we developed a sensitive assay using synthesized thyroxine fluorophore solved crystal structures cleaved TBG together with its complexes thyroxine, fluorophores, furosemide, mefenamic acid. Cleavage results complete insertion into substantial but...
Microcapsules have received considerable attention owing to their excellent self-healing properties, and many researchers attempted modify microcapsules’ characteristics meet the requirements of various applications. Owing physical chemical nanomaterial-modified (nanomodified) microcapsules can be used protect surface coatings internal structures cement-based materials. This paper summarizes progress in theoretical research practical application nanomodified materials, focusing on...
The hormone thyroxine that regulates mammalian metabolism is carried and stored in the blood by thyroxine-binding globulin (TBG). We demonstrate here release of from TBG occurs a temperature-sensitive mechanism show how this will provide homoeostatic adjustment concentration to match metabolic needs, as with hypothermia torpor small animals. In humans, rise temperature, infections, trigger an accelerated thyroxine, resulting predictable 23% increase free at 39°C. vivo relevance...
Pancreatic cancer (PC) is one of the most lethal human malignancies without effective treatment. In an effort to discover key genes and molecular pathways underlying PC growth, we have identified LIM domain only 7 (LMO7) as under-investigated molecule, which highly expresses in primary metastatic mouse with potential impacting tumorigenesis metastasis. Using genetic methods siRNA, shRNA, CRISPR-Cas9, successfully generated stable cells LMO7 knockdown or knockout. these loss function,...
Combination therapy represents an effective therapeutic approach to overcome hepatocellular cancer (HCC) resistance immune checkpoint blockade (ICB). Based upon previous work demonstrating that nanoliposome C6-ceramide (LipC6) not only induces HCC apoptosis but also prevents HCC-induced tolerance, we now investigate the potential of LipC6 in combination with ICB treatment. We generated orthotopic HCC-bearing mice, which have typical features common human patients, and then treated them...
Oleic acid (OA) stimulates vascular smooth muscle cell (VSMC) proliferation and migration. The precise mechanism is still unclear. We sought to investigate the effects of peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator-1 alpha (PGC-1alpha) on OA-induced VSMC migration.Oleate palmitate, most abundant monounsaturated fatty saturated in plasma, respectively, differently affect mRNA protein levels PGC-1alpha VSMCs. OA treatment resulted a reduction expression, which may...