A5000341566- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Neuroendocrine Tumor Research Advances
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Cancer Research and Treatments
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Liver physiology and pathology
- Colorectal Cancer Surgical Treatments
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Gut microbiota and health
- Cancer Mechanisms and Therapy
- Colorectal Cancer Treatments and Studies
- Gastrointestinal disorders and treatments
University of Missouri Health System
2020-2024
University of Missouri
2016-2024
Harry S. Truman Memorial Veterans' Hospital
2019-2024
University of Connecticut
2024
UConn Health
2024
Johns Hopkins University
2023
University of Missouri Hospital
2019-2022
Washington University in St. Louis
2021-2022
Virginia Hospital Center
2020
Medical University of South Carolina
2013-2016
Abstract The interplay between western diet and gut microbiota drives the development of non-alcoholic fatty liver disease its progression to steatohepatitis. However, specific microbial metabolic mediators contributing steatohepatitis remain be identified. Here, a choline-low high-fat high-sugar diet, representing typical named CL-HFS, successfully induces male mouse with some features human disease, such as hepatic inflammation, steatosis, fibrosis. Metataxonomic metabolomic studies...
Ceramide, a sphingolipid metabolite, affects T-cell signaling, induces apoptosis of cancer cells, and slows tumor growth in mice. However, it has not been used as chemotherapeutic agent because its cell impermeability precipitation aqueous solution. We developed nanoliposome-loaded C6-ceremide (LipC6) to overcome this limitation investigated effects mice with liver tumors.Immune competent C57BL/6 received intraperitoneal injections carbon tetrachloride intra-splenic oncogenic hepatocytes. As...
Background Minimally invasive radiofrequency ablation (RFA) is used as a first-line treatment option for hepatocellular cancer (HCC) with the weaknesses of incomplete ablation, tumor recurrence, and inferior outcomes. To overcome this limitation, we proposed to develop sunitinib-RFA integrated therapy potential activating anti-HCC immune response. Methods Using our unique murine model, developed novel RFA platform modified human cardiac RF generator. Therapeutic efficacy sunitinib–RFA...
Abstract Exosomes are extracellular vesicles which released from healthy and tumor cells into blood circulation. Unique biomolecular cargos such as RNA protein loaded in these vesicles. These molecules may have biological functions signaling, cell communications the potential to be analyzed biomarkers. In this initial study, we describe analysis of exosomes serum subjects, intraductal papillary mucosal neoplasms pancreatic ductal adenocarcinoma including characterization their by next...
Tumor-associated macrophages (TAMs), as a major and essential component of tumor microenvironment (TME), play critical role in orchestrating pancreatic cancer (PaC) tumorigenesis from initiation to angiogenesis, growth, systemic dissemination, well immunosuppression resistance chemotherapy immunotherapy; however, the intrinsic factors responsible for TAMs reprograming function remain be identified. By performing single-cell RNA sequencing, transforming growth factor-beta-induced protein...
Circulating tumor cells (CTCs) are of recognized importance for diagnosis and prognosis cancer patients. With melanoma, most studies do not show any clear relationship between CTC levels stage disease. Here, CTCs were enriched (∼400X) from blood melanoma patients using a simple centrifugation device (OncoQuick), 4 melanocyte target RNAs (TYR, MLANA, MITF, MIF) quantified QPCR. Approximately one-third had elevated MIF MLANA transcripts (p<0.0001 p<0.001, respectively) compared with healthy...
Background: Colorectal cancer (CRC) metastasectomy improves survival, however most patient develop recurrences. Circulating tumor cells (CTCs) are an independent prognostic marker in stage IV CRC. We hypothesized that CTCs can be enriched during applying different isolation techniques. Methods: 25 CRC patients undergoing liver (16 (64%)) or lung (9 (36%)) were prospectively enrolled (clinicaltrial.gov identifier: NCT01722903). Central venous (liver) radial artery (lung) outflow blood (7.5...
In addition to the FDA-approved definition of a circulating tumor cell (CTC), various CTC phenotypes have been discovered. Epithelial-mesenchymal transition (EMT) cancer cells is directly linked PD-L1 upregulation. The goal study was investigate expression and EMT in CTCs non-small lung (NSCLC) patients, perform an outcome analysis. Prospectively, 7.5 mL peripheral blood collected from 30 NSCLC patients that underwent surgery 15 healthy controls. were enriched by size-based microfilter...
<h3>Background and objectives</h3> Hepatocellular carcinoma (HCC) affects an increasing number of people worldwide. The poor survival rate patients with HCC is manifested by aggressive metastatic phenotype, as well a response to common therapeutic strategies. purpose this study was evaluate the efficacy nanoliposomal C6-ceramide antineoplastic agent in vivo model human HCC. <h3>Methods</h3> growth-arresting pro-apoptotic properties were first evaluated vitro SK-HEP-1 cells assessing cellular...
Pancreatic cancer is the sixth leading cause of cancer-related mortality globally. As most common form pancreatic cancer, ductal adenocarcinoma (PDAC) represents up to 95% all cases, accounting for more than 300,000 deaths annually. Due lack early diagnoses and high refractory response currently available treatments, PDAC has a very poor prognosis, with 5-year overall survival rate less 10%. Targeted therapy immunotherapy are highly effective have been used treatment many types cancer;...
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with very poor prognosis. Despite advancements in treatment strategies, PDAC remains recalcitrant to therapies because patients are often diagnosed at an advanced stage. The stage of characterized by metastasis, which typically renders it unresectable surgery or untreatable chemotherapy. tumor microenvironment (TME) comprises proliferative myofibroblast-like cells and hosts the intense deposition extracellular matrix...
Hepatocellular cancer (HCC), one of the world's most deadly tumors, and its incidence in US continues to rise. Surgical resection/transplantation offers only hope for cure; however, many patients are not candidates have limited therapeutic options. Opioid growth factor (OGF) is a naturally occurring bioactive endogenous pentapeptide that inhibits human HCC cell lines vitro by receptor-mediated mechanism progression tumors nude mice. Based on these preclinical studies, we conducted phase I...
Abstract Background Ancient schwannomas are degenerate peripheral nerve sheath tumors that very rarely occur in the retroperitoneum. They generally reach large proportions before producing symptoms due to mass effect. We describe three cases of retroperitoneal ancient and discuss diagnosis management these tumors. Case presentations Three female patients with were reviewed. One patient presented several weeks upper abdominal pain lower chest discomfort, whereas back leg associated weakness...