A5013536974- Radiopharmaceutical Chemistry and Applications
- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Neuropeptides and Animal Physiology
- Asymmetric Hydrogenation and Catalysis
- Neuroendocrine Tumor Research Advances
- Metal complexes synthesis and properties
- Organometallic Complex Synthesis and Catalysis
- Lung Cancer Research Studies
- Chemical Synthesis and Analysis
- Medical Imaging Techniques and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Medical Imaging and Pathology Studies
- Radiation Therapy and Dosimetry
- Nanoparticle-Based Drug Delivery
- Adipose Tissue and Metabolism
- Lung Cancer Treatments and Mutations
- Boron Compounds in Chemistry
- Pancreatic function and diabetes
- Lanthanide and Transition Metal Complexes
- RNA modifications and cancer
- Organometallic Compounds Synthesis and Characterization
- Growth Hormone and Insulin-like Growth Factors
- Dementia and Cognitive Impairment Research
- Nanoplatforms for cancer theranostics
University of Missouri
2013-2025
Newcastle University
2025
Harry S. Truman Memorial Veterans' Hospital
2012-2024
Memorial Hospital
2012-2024
Molecular Theranostics (United States)
2024
University of Birmingham
2022
University of Missouri Hospital
2019
National Nuclear Energy Commission
2012
United States Department of Veterans Affairs
2010
Royal Surrey County Hospital
2006
Development of cancer receptor-specific gold nanoparticles will allow efficient targeting/optimum retention engineered within tumors and thus provide synergistic advantages in oncology as it relates to molecular imaging therapy. Bombesin (BBN) peptides have demonstrated high affinity toward gastrin-releasing peptide (GRP) receptors vivo that are overexpressed prostate, breast, small-cell lung carcinoma. We synthesized a library GRP receptor-avid nanoplatforms by conjugating (AuNPs) with BBN...
Systemic delivery of therapeutic agents to solid tumors is hindered by vascular and interstitial barriers. We hypothesized that prostate tumor specific epigallocatechin-gallate (EGCg) functionalized radioactive gold nanoparticles, when delivered intratumorally (IT), would circumvent transport barriers, resulting in targeted payloads. The results described herein support our hypothesis. report the development inherently nanoparticles derived from Au-198 isotope; range 198 Au β-particle...
Exposure of insulin-responsive, differentiated 3T3-L1 cells (adipocytes) to 0.1 1.0 microgram/ml insulin for 3 48 h resulted in a persistent state enhanced 2-deoxy-D-glucose and 3-O-methyl-D-glucose uptake. Elevated basal transport activity was retained under conditions where 125I-insulin binding remained unchanged exchangeable dissociated from cell surface receptors. The appearance hexose prevented by cycloheximide could be distinguished the activation glucose system observed these other...
We report here production of MGF-<sup>198</sup>AuNPs and its application for prostate tumor therapy.
In addition to the FDA-approved definition of a circulating tumor cell (CTC), various CTC phenotypes have been discovered. Epithelial-mesenchymal transition (EMT) cancer cells is directly linked PD-L1 upregulation. The goal study was investigate expression and EMT in CTCs non-small lung (NSCLC) patients, perform an outcome analysis. Prospectively, 7.5 mL peripheral blood collected from 30 NSCLC patients that underwent surgery 15 healthy controls. were enriched by size-based microfilter...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesign and Development of Functionalized Water-Soluble Phosphines: Catalytic Biomedical ImplicationsKattesh V. Katti, Hariprasad Gali, Charles J. Smith, Douglas E. BerningView Author Information Departments Radiology Chemistry Missouri University Research Reactor, MissouriColumbia, Columbia, 65211 Cite this: Acc. Chem. Res. 1999, 32, 1, 9–17Publication Date (Web):September 18, 1998Publication History Received12 May 1998Published online18 September...
Bombesin (BBN), a 14 amino acid peptide, is an analogue of human gastrin releasing peptide (GRP) that binds to GRP receptors (GRPr) with high affinity and specificity. The GRPr overexpressed on variety cancer cells, including prostate, breast, lung, pancreatic cancers. specific aim this study was develop 99mTc-radiolabeled BBN analogues maintain specificity for the in vivo. A preselected synthetic sequence via solid-phase synthesis (SPPS) designed produce N3S−BBN (N3S =...
Nanocompatible chemistry which utilizes a novel nontoxic phosphino amino acid as reducing agent has resulted in the development of therapeutically useful gold nanoparticles under biologically benign media. Stabilization by edible gum arabic matrix provided an effective pathway toward vivo stable target-specific nanoparticles.
The gastrin-releasing peptide receptor (GRPR) is overexpressed in human prostate cancer. Bombesin (BBN) a neurotransmitter of 14 amino acids and binds with selectivity high affinity to GRPRs. We have synthesized NOTA-conjugated bombesin derivative, NOTA-8-Aoc-BBN(7-14)NH<sub>2</sub>, label this analog <sup>18</sup>F using the new Al<sup>18</sup>F method. In study, GRPR-targeting potential <sup>18</sup>F-labeled NOTA-8-Aoc-BBN(7-14)NH<sub>2</sub> was studied...
Cancer cells take up amino acids from the extracellular space to drive cell proliferation and viability. Similar mechanisms are applied by immune cells, resulting in competition between conventional T or indeed chimeric antigen receptor (CAR) tumor for limited availability of within environment. We demonstrate that can be re-engineered express SLC7A5 SLC7A11 transmembrane acid transporters alongside CARs. Transporter modifications increase CAR T-cell under low tryptophan cystine conditions...
Most of what is known about thalamic development comes from rodent studies, however, the increased proportion human association cortex has co-evolved with thalamocortical connectivity. Higher order nuclei, relaying information between cortical regions and important in higher cognitive function, are greatly expanded. This study mapped emergence nuclei fetal (8-16 post conceptional weeks; PCW) by revealing gene expression patterns using situ hybridization immunohistochemistry for previously...
<title>Abstract</title> Purpose In the United States, breast cancer is second leading cause of cancer-related death. Triple-negative (TNBC) substantial concern, as it lacks receptors usually targeted by conventional treatments. tumors have a high degree copper metabolism for synthesis transporters, enzymes, and chaperones. Tetrathiomolybdate (TM) well-tolerated oral therapy that has been investigated chelating from in TNBC patients, resulting extended remission. The overall goal this...
Abstract BACKGROUND Development of high affinity and specificity molecular imaging probes that increase accuracy for early detection lymph node (LN) metastases is important improving survivorship in prostate cancer. We evaluated the specificity, sensitivity, fluorescence‐labeled bombesin (BBN) peptides to detect LN systematic orthotopic mouse models bearing gastrin releasing peptide receptor (GRPR)‐positive human METHODS PC‐3 cells were orthotopically implanted severe combined...
We developed a novel site-specific bimodal MRI/fluorescence nanoparticle contrast agent targeting gastrin-releasing peptide receptors (GRPrs), which are overexpressed in aggressive prostate cancers. Biocompatible ultra-small superparamagnetic iron oxide (USPIO) nanoparticles were synthesized using glucose and casein coatings, followed by conjugation with Cy7.5-K-8AOC-BBN [7-14] conjugate. The resulting USPIO(Cy7.5)-BBN purified 100 kDa membrane dialysis fully characterized transmission...
Gastrin-releasing peptide (GRP) receptors are overexpressed on several types of human cancer cells, including breast, prostate, small cell lung, and pancreatic cancers. Bombesin (BBN), a 14-amino acid that is an analogue GRP, binds to GRP with very high affinity specificity. The aim this study was develop new fluorescent probe based BBN having tumor uptake optimal pharmacokinetics for specific targeting optical imaging breast tissue. In study, solid-phase synthesis used produce...