A5060370127- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Advanced Neuroimaging Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Psoriasis: Treatment and Pathogenesis
- Advanced MRI Techniques and Applications
- Dermatology and Skin Diseases
- Soil and Water Nutrient Dynamics
- Groundwater and Isotope Geochemistry
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Hydrology and Watershed Management Studies
- Groundwater flow and contamination studies
- Immune cells in cancer
- Structural Health Monitoring Techniques
- Allergic Rhinitis and Sensitization
- Blind Source Separation Techniques
- Hereditary Neurological Disorders
- Machine Fault Diagnosis Techniques
Charité - Universitätsmedizin Berlin
2017-2025
Humboldt-Universität zu Berlin
2019-2025
Freie Universität Berlin
2019-2025
Jilin University
2021-2025
Shanghai Jiao Tong University
2024
Ruijin Hospital
2024
University Hospital Cologne
2023
University of Cologne
2023
Tsinghua University
2021-2022
University Health Network
2021
The benefit of deep brain stimulation (DBS) for Parkinson disease (PD) may depend on connectivity between the site and other regions, but which regions whether can predict outcome in patients remain unknown. Here, we identify structural functional profile effective DBS to subthalamic nucleus (STN) test its ability an independent cohort.A training dataset 51 PD with STN was combined publicly available human connectome data (diffusion tractography resting state connectivity) connections...
Abstract Multiple surgical targets for treating obsessive-compulsive disorder with deep brain stimulation (DBS) have been proposed. However, different may modulate the same neural network responsible clinical improvement. We analyzed data from four cohorts of patients ( N = 50) that underwent DBS to anterior limb internal capsule (ALIC), nucleus accumbens or subthalamic (STN). The fiber bundle was associated optimal response in targeting either structure. This connected frontal regions STN....
Objective To investigate whether functional sweet spots of deep brain stimulation (DBS) in the subthalamic nucleus (STN) can predict motor improvement Parkinson disease (PD) patients. Methods Stimulation effects 449 DBS settings 21 PD patients were clinically and quantitatively assessed through standardized monopolar reviews mapped into standard space. A spot for best outcome was determined using voxelwise nonparametric permutation statistics. Two independent cohorts used to overlap with...
Following its introduction in 2014 and with support of a broad international community, the open-source toolbox Lead-DBS has evolved into comprehensive neuroimaging platform dedicated to localizing, reconstructing, visualizing electrodes implanted human brain, context deep brain stimulation (DBS) epilepsy monitoring. Expanding clinical indications for DBS, increasing availability related research tools, growing community clinician-scientist researchers, however, have led an ongoing need...
Abstract Frontal circuits play a critical role in motor, cognitive and affective processing, their dysfunction may result variety of brain disorders. However, exactly which frontal domains mediate (dys)functions remains largely elusive. We studied 534 deep stimulation electrodes implanted to treat four different By analyzing connections were modulated for optimal therapeutic response across these disorders, we segregated the cortex into that had become dysfunctional each them. Dysfunctional...
Abstract Deep Brain Stimulation can improve tremor, bradykinesia, rigidity, and axial symptoms in patients with Parkinson’s disease. Potentially, improving each symptom may require stimulation of different white matter tracts. Here, we study a large cohort (N = 237 from five centers) to identify tracts associated improvements the four domains. Tremor were connected primary motor cortex cerebellum. In contrast, are supplementary brainstem. Bradykinesia rigidity premotor cortices,...
Deep brain stimulation has local effects on the target structure, but also global via distributed networks. Horn et al. show that modulating activity of subthalamic nucleus in patients with Parkinson’s disease normalizes signatures widespread network connectivity towards those found healthy controls.
Nonlinear registration of individual brain MRI scans to standard templates is common practice in neuroimaging and multiple algorithms have been developed refined over the last 20 years. However, little has done quantitatively compare available much that work exclusively focused on cortical structures given their importance fMRI literature. In contrast, for clinical applications such as functional neurosurgery deep stimulation (DBS), proper alignment subcortical between template space...
Brain connectivity profiles seeding from deep brain stimulation (DBS) electrodes have emerged as informative tools to estimate outcome variability across DBS patients. Given the limitations of acquiring and processing patient-specific diffusion-weighted imaging data, a number studies employed normative atlases human connectome. To date, it remains unclear whether information would strengthen accuracy such analyses. Here, we compared similarities differences between patient-specific,...
Subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) not only stimulates focal target structures but also affects distributed networks. The impact this network modulation has on non-motor DBS effects is well-characterized. By focusing the affective domain, we systematically investigate of electrode placement and associated structural connectivity changes depressive symptoms following STN-DBS, which have been reported to improve, worsen, or remain...
Deep Brain Stimulation (DBS) is an established treatment option for movement disorders and under investigation in a growing number of other brain diseases. It has been shown that exact electrode placement crucially affects the efficacy DBS this should be considered when investigating novel indications or targets. To measure clinical improvement as function placement, neuroscientific methodology specialized software tools are needed. Such have goal to make comparable across patients centers,...
Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer's Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some but deteriorated others. This could be explained by variance electrode placement leading differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on multi-center cohort 46 DBS (NCT00658125, NCT01608061). Using normative structural and...
Up to 40% of patients with idiopathic generalised epilepsy (IGE) are drug resistant and potentially could benefit from intracranial neuromodulation the seizure circuit. We present outcomes following 2 years thalamic-responsive neurostimulation for IGE.
Brain signal decoding promises significant advances in the development of clinical brain computer interfaces (BCI). In Parkinson’s disease (PD), first bidirectional BCI implants for adaptive deep stimulation (DBS) are now available. can extend utility DBS but impact neural source, computational methods and PD pathophysiology on performance unknown. This represents an unmet need future neurotechnology. To address this, we developed invasive brain-signal approach based intraoperative...
Dystonia is a debilitating disease with few treatment options. One effective option deep brain stimulation (DBS) to the internal pallidum. While cervical and generalized forms of isolated dystonia have been targeted common approach posterior third nucleus, large-scale investigations regarding optimal sites potential network effects not carried out. Here, we retrospectively studied clinical results following DBS for in multicenter cohort 80 patients. We model electrode placement based on pre-...
Deep brain stimulation is an efficacious treatment for dystonia. While the internal pallidum serves as primary target, recently, of subthalamic nucleus (STN) has been investigated. However, optimal targeting within this structure and its surroundings have not studied in depth. Indeed, historical targets that used surgical dystonia are directly adjacent to STN. Further, multiple types exist, outcomes variable, suggesting all would profit maximally from same target. Therefore, a thorough...
Paeonol, an active component derived from the traditional Chinese medicine Cortex Moutan, possesses anti-inflammatory, analgesic, antioxidant and anti-allergic properties. Psoriasis is a chronic, recurrent, inflammatory dermatosis accompanied by excessive activation of Toll‑like receptors (TLRs) in dendritic cells (DCs), which are primarily responsible for initiating immune response. We investigated effect paeonol on inflammation imiquimod (IMQ)-induced psoriasis-like mouse model murine bone...
At least 25% of patients with idiopathic generalized epilepsy do not obtain adequate seizure control medication. This report describes the first use responsive neurostimulation (RNS), bilaterally targeting centromedian/ventrolateral (CM/VL) region in a patient drug-refractory Jeavons syndrome (eyelid myoclonia absences).A patient, diagnosed eyelid absences (EMA) and refractory to medication, was offered RNS treatment CM/VL thalamus. Stimulation triggered by thalamic neural activity having...
Abstract The subthalamic nucleus and internal pallidum are main target sites for deep brain stimulation in Parkinson’s disease. Multiple trials that investigated versus pallidal were unable to settle on a definitive optimal between the two. One reason could be effect is mediated via common functional network. To test this hypothesis, we calculated connectivity profiles seeding from electrodes 94 patients underwent 28 with treatment based normative connectome atlas 1000 healthy subjects. In...