A5011910232- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Vehicle Dynamics and Control Systems
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Soil Mechanics and Vehicle Dynamics
- Breast Cancer Treatment Studies
- Mechanical Engineering and Vibrations Research
- Autonomous Vehicle Technology and Safety
- Cancer Research and Treatments
- Virus-based gene therapy research
- Weed Control and Herbicide Applications
- Traffic control and management
- Transport Systems and Technology
- Hydraulic and Pneumatic Systems
- Cancer Genomics and Diagnostics
- RNA Interference and Gene Delivery
- Real-time simulation and control systems
- Animal Nutrition and Physiology
- Effects of Vibration on Health
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Vibration Control and Rheological Fluids
- Pesticide and Herbicide Environmental Studies
University of Cambridge
2014-2024
Medical University of South Carolina
2014-2024
Immunocore (United Kingdom)
2021
WellSpan York Hospital
2019
WellSpan Health
2019
Amec Foster Wheeler (Canada)
2018
MUSC Hollings Cancer Center
2006-2017
University of Oxford
1982-2017
Churchill Hospital
1986-2017
Shell (Netherlands)
2015
EpCAM (epithelial cell adhesion molecule) is a surface molecule that known to be highly expressed in colon and other epithelial carcinomas. involved cell-to-cell has been the target of antibody therapy several clinical trials. To assess value as novel for breast cancer gene therapy, we performed real-time reverse transcription-PCR quantify level mRNA expression normal tissue primary metastatic cancers. We found overexpressed 100- 1000-fold cancer. Silencing with short interfering RNA (siRNA)...
PURPOSE Based on preclinical evidence in murine models that interleukin-6 (IL-6) mediates regression of metastatic tumors, we performed a phase I study recombinant human IL-6 patients with refractory advanced malignancies to determine its pharmacokinetics, toxicities, and possible immunologic antitumor effects. PATIENTS AND METHODS Recombinant was administered as single subcutaneous dose daily for 7 days, days off therapy followed by another IL-6. Doses were escalated cohorts three starting...
Real-time RT-PCR is a relatively new technology that uses an online fluorescence detection system to determine gene expression levels. It has the potential significantly improve of breast cancer metastasis by virtue its exquisite sensitivity, high throughput capacity and quantitative readout system. To assess utility this in staging, we determined relative levels 12 cancer-associated genes (mam, PIP, mamB, CEA, CK19, VEGF, erbB2, muc1, c-myc, p97, vim Ki67) 51 negative-control normal lymph...
A brief review of the literature reveals that both predictive control theory and linear quadratic (LQ) have been used to design path-following controllers with preview, but it is not clear how compare. This article derives optimal preview using two approaches starting from a common state-space description vehicle dynamics. The transformation ground-fixed axes vehicle-fixed discussed. influences horizon, horizon cost function are investigated. For case long horizons, found LQ give identical...
PURPOSE A randomized prospective study was performed to compare the efficacy and toxicity of high-dose intravenous bolus interleukin-2 (IL-2) a lower-dose regimen for treatment metastatic renal cell carcinoma (RCC). PATIENTS AND METHODS Between March 1991 April 1993, 125 patients with RCC were receive IL-2 by every 8 hours at either 720,000 IU/kg (high-dose) or 72,000 (low-dose) maximum-tolerated number doses (or maximum 15 doses). After approximately 7 10 days, both groups re-treated second...
Development of vehicle active steering collision avoidance systems calls for mathematical models capable predicting a human driver's response so as to reduce the cost involved in field tests while accelerating product development. This paper provides discussion on paradigms that may be used modeling interaction with control path-following scenarios. Four paradigms, namely decentralized, noncooperative Nash, Stackelberg, and cooperative Pareto are established. The decentralized paradigm,...
In Brief Objective: To determine whether 1 of 2 vaccines based on dendritic cells (DCs) and poxvectors encoding CEA (carcinoembryonic antigen) MUC1 (PANVAC) would lengthen survival in patients with resected metastases colorectal cancer (CRC). Background: Recurrences after complete resections metastatic CRC remain frequent. Immune responses to are associated fewer recurrences, suggesting a role for as adjuvant therapy. Both DCs potent stimulators immune against antigens. Methods: Patients,...
Dendritic cells (DCs) enhance the quality of anti-tumor immune response in patients with cancer. Thus, we posit that DC-based immunotherapy, conjunction toll-like receptor (TLR)-3 agonist poly-ICLC, is a promising approach for harnessing immunity against metastatic or locally advanced unresectable pancreatic cancer (PC). We generated autologous DCs from peripheral blood HLA-A2+ PC. were pulsed three distinct A2-restricted peptides: 1) human telomerase reverse transcriptase (hTERT, TERT572Y),...
Abstract This paper is concerned with the modelling of strategic interactions between human driver and vehicle active front steering (AFS) controller in a path-following task where two controllers hold different target paths. The work aimed at extending use mathematical models representing behaviour complicated driving situations. Two game theoretic approaches, namely linear quadratic non-cooperative model predictive control (non-cooperative MPC), are used for developing driver–AFS...
Abstract Purpose Boswellic acids, active components of frankincense, suppress tumor proliferation in vitro with a strong clinical trial safety profile patients inflammatory diseases. We performed Phase Ia window opportunity Boswellia serrata ( B. ) breast cancer to evaluate its biologic activity and safety. Methods Patients invasive were treated pre-operatively Serrata (2400 mg/day PO) until the night before surgery for median 11 days (SD 6 days; range: 5–23 days). Paraffin-embedded sections...
Poly(I:C), a synthetic double-stranded RNA polymer and TLR3 agonist, can be used as vaccine adjuvant to enhance adaptive immunity. However, the antigen-specific CD8 T-cell response peptide vaccination poly(I:C) has not been clearly defined. Here, authors characterized specifically addressed hypothesis that antitumor To define response, established model based on adoptive transfer of T cells from OT-1 receptor transgenic mouse. In this model, with alone resulted in limited, transient...
A mathematical driver model is introduced in order to explain the steering behavior observed during successive double lane-change maneuvers. The consists of a linear quadratic regulator path-following controller coupled neuromuscular system (NMS). NMS generates wheel angle demanded by controller. demonstrates that reflex action and muscle cocontraction improve steer control thus increase accuracy. Muscle does not have destabilizing effect action, but there an energy cost. cost function used...
Although cyclophosphamide (CTX) has been clearly shown to enhance active specific and adoptive immunotherapies, the mechanism(s) underlying these beneficial effects have not defined. To define impact of CTX preconditioning on antigen-specific CD8 T-cell response peptide vaccination, we used an transfer model based OT-1 receptor transgenic mouse. dramatically enhanced vaccination. Specifically, significantly expansion function responding T cells as demonstrated by flow cytometry cytokine...
Abstract Recent preclinical studies suggest that vaccination following adoptive transfer of CD8+ T cells into a lymphopenic host can augment the therapeutic antitumor responses transferred cells. However, mechanism by which microenvironment benefits Ag-specific cell remains elusive. We show herein induction lymphodepletion single 4 mg cyclophosphamide (CTX) treatment induces marked expansion immature dendritic (DCs) in peripheral blood on days 8–16 post-CTX (termed restoration phase). In...
Advanced driver assistance systems (ADAS) aim to increase safety and reduce mental workload.However, the gap in understanding of closed-loop driver-vehicle interaction often leads reduced user acceptance.In this article, an optimal torque control law is calculated online model predictive (MPC) framework guarantee continuous guidance during steering task.The research contribution integration extensive prediction covering cognitive behavior, neuromuscular dynamics, vehicle-steering within...
<i>Background and Relevance:</i> Atherosclerotic stenosis of the major intracranial arteries is an important cause transient ischemic attack (TIA) or stroke. Of 900,000 patients who suffer a TIA stroke each year in USA, responsible for approximately 10%, i.e. 90,000 patients. There have been no prospective trials evaluating antithrombotic therapies preventing recurrent vascular events these The main objective this trial to compare warfarin [International Normalized Ratio (INR)...
The objective of the work described in this paper is to establish guidelines for design passive suspensions that cause minimum road damage. An efficient procedure calculating a realistic measure damage (the 95th percentile aggregate fourth power force) frequency domain derived. Simple models truck vibration are then used examine influence suspension parameters on criterion and select optimal values. It found minimize should have stiffness about one fifth current air damping up twice...