A5022537592- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Angiogenesis and VEGF in Cancer
- Genetic factors in colorectal cancer
- Clinical practice guidelines implementation
- Gastric Cancer Management and Outcomes
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Screening and Detection
- Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Neuroendocrine Tumor Research Advances
- Global Healthcare and Medical Tourism
- Cutaneous Melanoma Detection and Management
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Cancer Treatment and Pharmacology
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Metabolism, Diabetes, and Cancer
Michael E. DeBakey VA Medical Center
2021-2025
Baylor College of Medicine
2021-2025
Children's Cancer Center
2024
Northwestern University
2016-2024
Dan L Duncan Comprehensive Cancer Center
2022-2024
University of Southern California
2016-2023
The University of Texas MD Anderson Cancer Center
2005-2023
Baylor University Medical Center
2023
National Institutes of Health
2023
Medical University of South Carolina
2013-2022
Abstract Purpose: Epithelial-to-mesenchymal transition (EMT) is a process whereby cells acquire molecular alterations that facilitate cell motility and invasion. In preliminary studies, we observed oxaliplatin-resistant (OxR) colorectal cancer (CRC) underwent morphologic changes suggestive of migratory phenotype, leading us to hypothesize OxR CRC undergo EMT. Experimental Design: The human lines KM12L4 HT29 were exposed increasing doses oxaliplatin establish stable resistant oxaliplatin....
Abstract Our laboratory has shown that vascular endothelial growth factor receptor-1 (VEGFR-1) expression on human pancreatic cancer cell lines mediates migration and invasion. Because epithelial to mesenchymal transition (EMT) also plays a role in motility by altering the phenotype morphology, we hypothesized VEGFR-1 activation induces molecular alterations mediate EMT. treatment of line L3.6pl with ligands VEGF-A VEGF-B led morphologic changes characteristic EMT, including loss polarity,...
Abstract Targeted therapies that inhibit the activity of tyrosine kinase receptors such as epidermal growth factor receptor (EGFR) have shown against solid malignancies when used single agents or in combination with chemotherapy. Although anti-EGFR are active some patients, eventually disease nearly all patients will become refractory to therapy. Therefore, a better understanding mechanisms resistance is critical further improve efficacy this class agents. Mechanisms mediate include presence...
Epithelial-to-mesenchymal transition (EMT) has been closely linked with therapy resistance and cancer stem cells (CSCs). However, EMT pathways have proven challenging to therapeutically target. MicroRNA 145 (miR-145) targets multiple cell transcription factors its expression is inversely correlated EMT. Therefore, we hypothesized that miR-145 represents a therapeutic target reverse snail family transcriptional repressor 1 (SNAI1)-mediated stemness radiation (RT). Stable of SNAI1 in DLD1...
Abstract Pancreatic carcinomas express high levels of urokinase-type plasminogen activator (uPA) and its receptor (uPAR), both which mediate cell migration invasion. We investigated the hypotheses that (a) insulin-like growth factor-I (IGF-I)– hepatocyte factor (HGF)–mediated invasion human pancreatic carcinoma cells require uPA uPAR function (b) inhibition inhibits tumor growth, retroperitoneal invasion, hepatic metastasis in mice. Using transwell assays, we effect IGF-I HGF on L3.6pl...
Abstract Objectives/Hypothesis: Merkel cell carcinoma (MCC) is an aggressive cutaneous neoplasm that occurs most frequently in the head and neck region. Because of its rarity, prognostic factors are poorly characterized. Head MCC (HN‐MCC) may require separate consideration from other anatomic regions. Our objective was to determine relevance clinicopathologic parameters as a large series patients with HN‐MCC compare these non–head (NHN‐MCC). Study Design: Retrospective analysis population...
Abstract BACKGROUND Specific tyrosine kinase receptors such as c‐MET mediate epithelial‐mesenchymal (EMT) transition, leading to phenotypic alterations associated with increased cell motility. It was hypothesized that RON, a receptor related c‐MET, would be expressed in human pancreatic cancer cells, induce EMT, and thus serve target for therapy preclinical model. METHODS RON expression specimens assessed by immunohistochemistry. In lines, reverse‐transcriptase polymerase chain reaction...
Abstract BACKGROUND: Although epidemiologic studies suggest that metabolic syndrome (MetS) increases the risk of colorectal cancer, its effect on cancer mortality remains controversial. METHODS: The authors used Surveillance, Epidemiology, and End Results (SEER)‐Medicare linked database (1998‐2006) to conduct a retrospective cohort study 36,079 patients with colon determine independent MetS components overall survival (OS) recurrence‐free rates (RFRs). Data were ascertained from Medicare...
Abstract Introduction MicroRNAs are small non-coding RNAs that involved in the post-transcriptional negative regulation of mRNAs. MicroRNA 510 (miR-510) was initially shown to have a potential oncogenic role breast cancer by observation its elevated levels human tumor samples when compared matched non-tumor samples. Few targets been identified for miR-510. However, as microRNAs function through their direct targets, identification those is critical understanding functional cancer. Methods...
To compare image quality on contrast-enhanced dual-energy computed tomography (DECT) during the pancreatic parenchymal phase of masses between linearly-blended simulated 120 kVp images (routine) and advanced image-based virtual monoenergetic reconstructions at 55 keV.This was a retrospective evaluation 24 nonconsecutive adults found to have focal mass multiphasic abdominal dual-source DECT (12 adenocarcinoma, 5 neuroendocrine, 7 cystic tumors). For pancreatic-parenchymal images, subjects had...
Epithelial-to-mesenchymal transition (EMT) has been associated with poor treatment outcomes in various malignancies and is inversely miRNA145 expression. Therefore, we hypothesized that SNAI2 (Slug) may mediate 5-fluorouracil (5FU) chemotherapy resistance through inhibition of miR145 colorectal cancer thus represents a novel therapeutic target to enhance current strategies. Compared parental DLD1 colon cells, 5FU-resistant (5FUr) cells demonstrated features EMT, including >2-fold enhanced...
We identified unique molecular mechanisms of resistance to CDK4/6 inhibitors, an area intense biomedical investigation.
Progress in rectal cancer therapy has been hindered by the lack of effective disease-specific preclinical models that account for unique molecular profile and biology cancer. Thus, we developed complementary patient-derived xenograft (PDX) subsequent vitro tumor organoid (PDTO) platforms established from preneoadjuvant specimens to advance personalized care patients. Multiple endoscopic samples were obtained 26 Stages 2 3 patients prior receiving 5FU/RT implanted subcutaneously into NSG mice...
The effect of sentinel lymph node status on survival in patients with Merkel cell carcinoma (MCC) the head and neck is uncertain.We used Surveillance Epidemiology End Results (SEER) database to identify MCC who underwent biopsy (SLNB). Clinicopathologic data disease-specific (DSS) were compared among positive negative nodes.We identified 721 cutaneous SLNB, which 173 (24%) had MCC. rate positivity was 23.1%. Sentinel metastasis did not significantly affect (p = .139).Using SEER database, we...
RAS guanosine triphosphatases (GTPases) are mutated in nearly 20% of human tumors, making them an attractive therapeutic target. Following our discovery that nucleotide-free (apo RAS) regulates cell signaling, we selectively target this state as approach to inhibit function. Here, describe the R15 monobody exclusively binds apo all three isoforms vitro, regardless mutation status, and captures cells. inhibits signaling transforming activity a subset mutants with elevated intrinsic nucleotide...