A5034672760- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Sphingolipid Metabolism and Signaling
- T-cell and B-cell Immunology
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Phytochemistry and Bioactivity Studies
- Inflammatory mediators and NSAID effects
- Autophagy in Disease and Therapy
- RNA and protein synthesis mechanisms
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Hedgehog Signaling Pathway Studies
- Colorectal Cancer Surgical Treatments
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
Baylor College of Medicine
2022-2025
Molecular Biology Consortium
2024
Medical University of South Carolina
2016-2021
MUSC Hollings Cancer Center
2020-2021
Hiroshima University
2008-2011
Sri Ramachandra Institute of Higher Education and Research
2007
Madras Medical Mission
2007
Progress in rectal cancer therapy has been hindered by the lack of effective disease-specific preclinical models that account for unique molecular profile and biology cancer. Thus, we developed complementary patient-derived xenograft (PDX) subsequent vitro tumor organoid (PDTO) platforms established from preneoadjuvant specimens to advance personalized care patients. Multiple endoscopic samples were obtained 26 Stages 2 3 patients prior receiving 5FU/RT implanted subcutaneously into NSG mice...
Abstract Repetitive stimulation of T-cell receptor (TCR) with cognate antigen results in robust proliferation and expansion the T cells, also imprints them replicative senescence signatures. Our previous studies have shown that life-span antitumor function cells can be enhanced by inhibiting reactive oxygen species (ROS) or intervening ROS-dependent JNK activation leads to its activation-induced cell death. Because tumor suppressor protein p53 is a redox active transcription factor regulates...
Purpose Human papillomavirus (HPV) infected oropharyngeal squamous cell carcinoma (OPSCC) patients have a better prognosis compared to HPV(-) counterparts. However, subset of HPV(+) with smoking history fail respond the standard care treatments such as radiation and chemotherapy. To understand underlying mechanism driving OPSCC patient resistance treatment recurrence, we sought identify characterize differentially expressed miRNAs their target genes in smokers non-smokers. Experimental...
Epithelial-to-mesenchymal transition (EMT), cancer stem cells (CSCs), and colorectal (CRC) therapy resistance are closely associated. Prior reports have demonstrated that sphingosine-1-phosphate (S1P) supports maintains the CSC phenotype. We hypothesized EMT inducer SNAI1 drives S1P signaling to amplify self-renewal capacity chemoresistance.
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer resistant to current therapies, including oxaliplatin (Oxa). Growing evidence supports the ability of cancers harness sphingolipid metabolism for survival. Sphingosine-1-phosphate (S1P) anti-apoptotic, pro-survival mediator that can influence cellular functions such as endoplasmic reticulum (ER) stress. We hypothesize PDAC drives dysregulated and S1P inhibition enhance ER stress improve therapeutic response Oxa in PDAC.
Hu Antigen R, also known as ELAVL1 (HuR), is a key posttranscriptional regulator in eukaryotic cells. HuR overexpression promotes several malignancies, including head and neck squamous cell carcinoma (HNSCC). However, its immune dysfunction-associated tumorigenesis pathways remain unknown. We examined HuR's effects on oral malignancies function vitro vivo using cells transgenic knockout (KO) mice. CRISPR/Cas9-mediated deletion mice syngeneic cancer eliminated colony formation tumor...
// Radhika R. Gudi 1 , Harinarayanan Janakiraman 2 Philip H. Howe Viswanathan Palanisamy and Chenthamarakshan Vasu Department of Microbiology Immunology, Medical University South Carolina, Charleston, USA Biochemistry, Correspondence to: Gudi, email: gudi@musc.edu Vasu, vasu@musc.edu Keywords: tumorigenesis; epithelial-mesenchymal transition; oral squamous cell carcinoma; EGFR; CPAP Received: November 15, 2020     Accepted: March 22, 2021    ...
The use of humanized mouse models for oncology is rapidly expanding. Autologous patient-derived systems are particularly attractive as they can model the human cancer's heterogeneity and immune microenvironment. In this study, we developed an autologous cancer by engrafting NSG mice with xenografts infused matched peripheral blood mononuclear cells (PBMCs). We first defined time course xenogeneic graft-versus-host-disease (xGVHD) determined that only minimal xGVHD was observed up to 8 weeks....
<div>Abstract<p>Repetitive stimulation of T-cell receptor (TCR) with cognate antigen results in robust proliferation and expansion the T cells, also imprints them replicative senescence signatures. Our previous studies have shown that life-span antitumor function cells can be enhanced by inhibiting reactive oxygen species (ROS) or intervening ROS-dependent JNK activation leads to its activation-induced cell death. Because tumor suppressor protein <i>p53</i> is a redox...
<div>Abstract<p>Repetitive stimulation of T-cell receptor (TCR) with cognate antigen results in robust proliferation and expansion the T cells, also imprints them replicative senescence signatures. Our previous studies have shown that life-span antitumor function cells can be enhanced by inhibiting reactive oxygen species (ROS) or intervening ROS-dependent JNK activation leads to its activation-induced cell death. Because tumor suppressor protein <i>p53</i> is a redox...
<p>Details for comparative characterization of phenotype and anti-tumor function between the p53-KO vs. WT T cells are included.</p>
<p>Details for comparative characterization of the phenotype, and anti-tumor function p53-KO vs Wt T cells is included.</p>
<p>Details for comparative characterization of phenotype and anti-tumor function between the p53-KO vs. WT T cells are included.</p>
<p>Details for comparative characterization of the phenotype, and anti-tumor function p53-KO vs Wt T cells is included.</p>
Abstract Oral squamous cell carcinoma (OSCC) is the most common type of head and neck (HNSCC). Altered epidermal growth factor receptor (EGFR) levels can contribute to tumor metastasis resistance therapies. The epithelial-mesenchymal transition (EMT), by which epithelial cells acquire a mesenchymal invasive phenotype, contributes significantly in OSCC, EGFR signaling known promote this process. Microtubule inhibition therapies cause inactivation or increase sensitivity targeting drugs...