A5103181094- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- Cancer Genomics and Diagnostics
- Planarian Biology and Electrostimulation
- Marine Ecology and Invasive Species
- BRCA gene mutations in cancer
- Circular RNAs in diseases
- Alzheimer's disease research and treatments
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Advanced Proteomics Techniques and Applications
- CRISPR and Genetic Engineering
- Genomic variations and chromosomal abnormalities
- Nutrition, Genetics, and Disease
- Creativity in Education and Neuroscience
- Immune cells in cancer
- Cancer Risks and Factors
- Autism Spectrum Disorder Research
- S100 Proteins and Annexins
- Genomics and Rare Diseases
- Breast Cancer Treatment Studies
- Metabolomics and Mass Spectrometry Studies
- Genetics and Neurodevelopmental Disorders
ZheJiang Academy of Agricultural Sciences
2023-2025
Institute of Hydrobiology
2023-2025
Shanghai University of Medicine and Health Sciences
2020-2025
Jilin University
2021-2025
Union Hospital
2021-2025
Leicester Royal Infirmary
2023-2024
University of Leicester
2023-2024
Hangzhou Women’s Hospital
2024
Woman's Hospital
2024
Medical University of South Carolina
2013-2024
Associations between taxane-related sensory neuropathy (TRSN) and single-nucleotide polymorphisms (SNP) have previously been reported, but few replicated in large, independent validation studies. This study evaluates the association investigated SNPs TRSN, using genotype data from a of chemotherapy-related toxicity patients with breast cancer.
In developing inhibitors of the LIM kinases, initial lead molecules combined potent target inhibition with cytotoxic activity. However, as subsequent compounds were evaluated, activity separated from kinases. A rapid determination mechanism and its molecular was enabled by integrating data two robust core technologies. High-content assays gene expression profiling both indicated an effect on microtubule stability. Although are still kinase inhibitors, their structures did not predict tubulin...
Using CRISPR/Cas9 delivered as a RNA modality in conjunction with lipid specifically formulated for large molecules, we demonstrate that homology directed repair (HDR) rates between 20-40% can be achieved induced pluripotent stem cells (iPSC). Furthermore, low HDR (between 1-20%) enhanced two- to ten-fold both iPSCs and HEK293 by 'cold shocking' at 32 °C 24-48 hours following transfection. This method also increases the proportion of loci have undergone complete sequence conversion across...
Abstract INTRODUCTION Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, yet our comprehension predominantly relies on studies within non‐Hispanic White (NHW) populations. Here we provide an extensive survey of proteomic landscape AD across diverse racial/ethnic groups. METHODS Two cortical regions, from multiple centers, were harmonized by uniform neuropathological diagnosis. Among 998 unique donors, 273 donors self‐identified as African American, 229 Latino and 434...
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, yet our comprehension predominantly relies on studies within non-Hispanic White (NHW) population. Here we aimed to provide comprehensive insights into proteomic landscape of AD across diverse racial and ethnic groups.
Abstract Introduction MicroRNAs are small non-coding RNAs that involved in the post-transcriptional negative regulation of mRNAs. MicroRNA 510 (miR-510) was initially shown to have a potential oncogenic role breast cancer by observation its elevated levels human tumor samples when compared matched non-tumor samples. Few targets been identified for miR-510. However, as microRNAs function through their direct targets, identification those is critical understanding functional cancer. Methods...
There is increasing evidence that elevated body mass index (BMI) associated with reduced survival for women breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate possible causal role of BMI in from
Previous studies reported that miR-330-3p was involved in the progression of several cancers, but potential roles ovarian cancer (OC) were unclear. In current study, we aimed to explore expression pattern and functions OC. The level OC tissues cell lines detected using RT-qPCR. proliferation, migration invasion cells CCK-8 assay transwell assay, respectively. Bioinformatics analysis luciferase reporter used analyze targeted binding site RIPK4. results showed significantly downregulated...
Heparin binding proteins (HBPs) with roles in extracellular matrix assembly are strongly correlated to β-amyloid (Aβ) and tau pathology Alzheimer's disease (AD) brain cerebrospinal fluid (CSF). However, it remains challenging detect these plasma using standard mass spectrometry-based proteomic approaches.
In swine production, weaning is a critical event for porcine weaning-associated disease, such as postweaning stress syndrome, which involves intestinal dysfunction. However, little known about the molecular mechanisms of dysfunction in pigs during weaning. To gain new insight into interaction between and function, 4 at 25 d age each suckling groups total 40 were used to analyze changes genomic expression intestines weaned by microarray analysis. Four hundred forty-five genes showed altered...
Abstract Inflammation is a critical component involved in tumor progression. Interleukin-17 (IL-17) belongs to relatively new family of cytokines that has been associated with the progression cancers. However, role IL-17B/IL-17RB (IL-17 receptor B) signaling stemness gastric cancer remains unknown. Here, we confirmed expression IL-17RB tissues was significantly increased, overexpression poor prognosis patients, and positively correlated some markers. Interestingly, IL-17B upregulated patient...
The simplicity and precision of CRISPR/Cas9 system has brought in a new era gene editing. Screening for desired clones with CRISPR-mediated genomic edits large number samples is made possible by next generation sequencing (NGS) due to its multiplexing. Here we present CRISPR-DAV (CRISPR Data Analysis Visualization) pipeline analyze the CRISPR NGS data high throughput manner. In pipeline, Burrows-Wheeler Aligner Assembly Based ReAlignment are used small indel detection, results presented...
sarcopenia has been defined as the aging-related disease with declined mass, strength, and function of skeletal muscle, which is a major cause morbidity mortality in elders. Current diagnostic criteria have not agreed internationally, clinical biomarkers for identified. Circulating miRNAs (miRNAs, miRs) recently characterized novel sarcopenia. However, change circulating response to are still fully understood. Here, we enrolled total 93 elderly patients clinically diagnosed matching...
Abstract Identifying the underlying genetic drivers of heritability breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets provide new insights into potential function germline variants in prognosis. This analysis studies ~7.3 million 84,457 patients relation survival and confirms results on 12,381 independent patients. Aggregating prognostic effects across multiple genes, we identify four gene modules associated with estrogen...
Abstract Epilepsy is a prevalent neurological disorder in which hippocampal neuronal damage, particularly ferroptosis, plays critical role. Previous studies have shown that hypoxia-inducible factor 1α considered an important regulator of cellular stress responses and has been confirmed to play role the occurrence various diseases. However, mechanisms by related epilepsy ferroptosis remain unclear. In this study, we used pentylentetrazole-induced chronic mouse model treated mice with...