A5102894357- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Galectins and Cancer Biology
- Neuroendocrine Tumor Research Advances
- Cancer Mechanisms and Therapy
- Signaling Pathways in Disease
- Pancreatic function and diabetes
- Phagocytosis and Immune Regulation
- Renal cell carcinoma treatment
- Cancer-related Molecular Pathways
- Esophageal and GI Pathology
- RNA Research and Splicing
- Glycosylation and Glycoproteins Research
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Macrophage Migration Inhibitory Factor
- Glioma Diagnosis and Treatment
Nanjing Medical University
2016-2025
Jiangsu Province Hospital
2016-2025
University of Missouri
2021
Wuxi No.2 People's Hospital
2019
Wuxi Fourth People's Hospital
2019
Pancreas Centre (Canada)
2016
Pancreatic cancer (PC) is an extremely malignant tumor with low survival rate. Effective biomarkers and therapeutic targets for PC are lacking. The roles of circular RNAs (circRNAs) in cancers have been explored various studies, however more work needed to understand the functional specific circRNAs. In this study, we explore role mechanism circ_0035435 (termed circCGNL1) PC.
Antigen-presenting cells (APCs) process tumor vaccines and present antigens as the first signals to T activate anti-tumor immunity, which requires assistance of co-stimulatory second on APCs. The immune checkpoint programmed death ligand 1 (PD-L1) not only mediates escape but also acts a co-inhibitory signal serious dysfunction due high expression PD-L1 APCs in body results inefficiency vaccines. To overcome this challenge, previously established Plug-and-Display vaccine platform based...
Pancreatic ductal adenocarcinoma (PDAC) is one of the malignant lethal tumors. It has been reported that transcriptional regulator Yin Yang-1 (YY1) suppressed invasion and metastasis PDAC. However, function YY1 on proliferation migration pancreatic cancer remains to be clarified. In this study, we found overexpression or knockdown can inhibit promote cells. Digital gene expression sequencing indicates cyclin-dependent kinase inhibitor 3 (CDKN3) may candidate target YY1. Then downregulate...
Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive and characterized by pronounced desmoplasia. PDAC cells communicate with cancer-associated fibroblasts (CAFs) in a paracrine/reciprocal manner, substantially promoting tumor growth desmoplastic responses. This study highlights the critical role of anterior gradient 2 (AGR2), an endoplasmic reticulum protein disulfide isomerase, secreted to activate CAFs via Wnt signaling pathway. Activated CAFs, turn, secrete insulin-like factor 1...
// Jing-Jing Zhang 1, 2, 3, * , Yi Zhu Chuang Yang 3 Xian Liu Yun-Peng Peng Kui-Rong Jiang Miao Ze-Kuan Xu 1 Pancreas Institute of Nanjing Medical University, 210029, People's Republic China 2 Center, The First Affiliated Hospital Department General Surgery, These authors contributed equally to this work Correspondence to: Miao, email: miaoyi@njmu.edu.cn Ze-kuan Xu, xuzekuan@njmu.edu.cn Keywords: Yin Yang-1, pancreatic cancer, apoptosis, Bax Received: January 28, 2016 Accepted: March...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors has worst prognoses, and role long noncoding RNAs (lncRNAs) in biological pathological processes pancreatic cancer, including tumor cell proliferation, a popular topic research. Our previous study revealed correlation between high levels lncRNA‐SOX2OT (SOX2OT) with poor survival outcomes. Cell Counting Kit‐8, EdU, Flow cytometry Colony formation assays as well Xenograft growth PDAC cells mice were used for detection...
Pancreatic cancer (PC) is one of the most lethal human malignancies without effective treatment. In an effort to discover key genes and molecular pathways underlying PC growth, we have identified LIM domain only 7 (LMO7) as under-investigated molecule, which highly expresses in primary metastatic mouse with potential impacting tumorigenesis metastasis. Using genetic methods siRNA, shRNA, CRISPR-Cas9, successfully generated stable cells LMO7 knockdown or knockout. these loss function,...
To determine the interobserver variability for complications of pancreatoduodenectomy as defined by International Study Group Pancreatic Surgery (ISGPS) and others. Good definitions surgical is major importance in comparing outcomes between within centers. However, data on pancreatoduodenectomy-specific are lacking. cross-sectional multicenter study including 52 raters from 13 high-volume pancreatic centers 8 countries 3 continents. Per center, 4 experienced scored 30 randomly selected...
Gastric cancer is the second highest mortality tumor and fourth most common worldwide that has high aggressiveness. MicroRNA-181d (miR-181d) been established to be a suppressor, by suppressing cell proliferation, cycle, promoting apoptosis in several cancers. The purpose of this study explore great roles miR-181d gastric cancer.The Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) Western blot were applied calculate mRNA protein levels genes. MTT...
Telomere shortening and RNA pseudo-uridylation are common features of tumors. NOP10 is a member the H/ACA snoRNP family, essential for maintaining telomerase activity pseudouridylation. has been indicated to be substantially expressed in tumors such as breast lung cancers associated with poor prognosis. Currently, no investigation exists on pancreatic cancer (PC). This first elucidate impact tumorigenesis prognostic value adenocarcinoma (PAAD). expression its survival significance were...
Primary cultures of pancreatic stellate cells (PSCs) remain an important basis for in vitro study. However, effective methods isolating abundant PSCs are currently lacking. We report on a novel approach to from normal rat pancreases and human ductal adenocarcinoma (PDAC) tissue. After anaesthesia laparotomy the rat, blunt cannula was inserted into duct through anti-mesentery side duodenum, pancreas slowly infused with enzyme solution until all lobules were fully dispersed. The then...
// Yi Zhu 1, 2, 3, * , Jing-Jing Zhang Yun-Peng Peng Xian Liu 3 Kun-Ling Xie 4 Jie Tang 5 Kui-Rong Jiang Wen-Tao Gao Lei Tian Kai Ze-Kuan Xu Miao 1 Pancreas Institute of Nanjing Medical University, Nanjing, People's Republic China 2 Center, The First Affiliated Hospital Department General Surgery, Bozhou, Anhui, Pediatric Children's to These authors have contributed equally this work Correspondence to: Zekuan Xu, email: xuzekuan@njmu.edu.cn Miao, miaoyi@njmu.edu.cn Keywords: NIDO, AMOP, vWD,...
Pancreatic adenocarcinoma (PAAD) is a highly lethal malignancy characterized by aggressive growth and poor prognosis. Understanding the molecular mechanisms underlying PAAD crucial for developing effective therapies. This study aimed to explore role of
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with five-year survival rate of 13%, the lowest among all tumors. The work aims to use bioinformatics methods mine Nerve-cancer crosstalk-related genes (NCCGs) in pancreatic cancer and evaluate their correlation stage prognosis, thereby providing new direction development experimental basis for treatment. This study included 185 individuals PDAC from TCGA database, together clinical RNA sequencing data. A review prior...
Pancreatic cancer (PC) is a highly invasive malignancy with extremely poor prognosis. STK31 has been identified as cancer-testis (CT) gene, but its function in PC not elucidated well.The effect of on cell proliferation, migration and invasion was investigated by vitro vivo experiments total RNA sequencing targeted bisulfite applied to explore the potential regulatory mechanisms PC.By analysis tissue samples clinicopathologic features, we found that reactivated associated In addition, studies...
Pancreatic ductal adenocarcinoma (PDAC) is one of the common malignant tumors with high lethal rate and poor prognosis. Dysregulation many genes have been reported to be involved in occurrence development PDAC. However, as a highly conserved gene eukaryotes, role Fasciculation Elongation protein Zeta 2 (FEZ2) pancreatic cancer progression not clear. In this study, we identified oncogenic effect FEZ2 on By mining The Cancer Genome Atlas (TCGA) database, found that was upregulated PDAC tissues...