A5101549830- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Cancer Cells and Metastasis
- Renal cell carcinoma treatment
- Liver Disease Diagnosis and Treatment
- Regional Economic and Spatial Analysis
- Neuroendocrine Tumor Research Advances
- Hippo pathway signaling and YAP/TAZ
- Gastrointestinal disorders and treatments
- Wnt/β-catenin signaling in development and cancer
- Liver Disease and Transplantation
- Spinal Cord Injury Research
- Tracheal and airway disorders
- Pharmacological Effects of Natural Compounds
- Cancer Research and Treatments
- Gastric Cancer Management and Outcomes
- melanin and skin pigmentation
- Chemical Reactions and Isotopes
- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
- Medical Imaging and Pathology Studies
- Lipid metabolism and disorders
- Gastrointestinal Tumor Research and Treatment
- Sirtuins and Resveratrol in Medicine
- Lung Cancer Treatments and Mutations
Nanjing Medical University
2011-2025
Sir Run Run Shaw Hospital
2025
Zhejiang University
2025
Jiangsu Province Hospital
2006-2024
First People's Hospital of Chongqing
2023
Nanyang Institute of Technology
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022
Chongqing Medical University
2022
First Affiliated Hospital of Xi'an Jiaotong University
2018-2021
Suzhou Municipal Hospital
2020
Background: Acetylcholine (ACh), a neurotransmitter of vagal nerve, offers tolerance to ischemia/reperfusion injury. Given the regulation autophagy in cardioprotection, this study was examine role ACh-elicited protection against hypoxia/reoxygenation (HR) Methods: H9c2 cells were subjected HR Autophagy determined by transmission electron microscopy, MDC staining and western blot. MTT kit, LDH CK release, ATP content TUNEL assay used evaluate cardiomyocytes Atg7 AMPK knockdown performed with...
Background/Aims: Acetylcholine (ACh) is known to modulate the cardiac redox environment and thereby suppress reactive oxygen species (ROS) generation during oxidative stress. However, there little information about its regulation on ROS clearance. Here we investigate beneficial effects of ACh superoxide dismutase (SOD) as key ROS-detoxifying enzyme system in cultured rat cardiomyoblasts. Methods: H9c2 cells were subjected hypoxia/reoxygenation (H/R) mimic Western blot was used detect...
Abstract Drug resistance limits the clinical efficacy of breast cancer therapies, and overexpression or activation Yes‐associated protein (YAP) is common in drug‐resistant cells. Thus, inhibition YAP may reduce to anti‐cancer drugs. Metformin (MET), a first‐line diabetes medication that also has anti‐tumour activities, induces AMP‐activated kinase (AMPK), directly phosphorylates inhibits transcriptional activity. In this study, we determined effect MET on proliferation invasion cells then...
Abstract Study design Animal study. Objectives To investigate the influence of lumbar arteries ligation on spinal cord blood flow (SCBF), and to determine by what proportion SCBF decrease would cause ischemia (SCI) in rabbit model. Setting Sir Run Shaw Hospital, Zhejiang University School Medicine. Methods SCI model was established rabbits. 20 rabbits were divided into four groups: group A, sham surgery without ligation; B, at 3 levels; C, 4 D, 5 levels. The measured with laser doppler...
Summary Aerobic interval training ( AIT ) exerts beneficial effects on cardiovascular disease. However, its cardioprotective mechanisms are not fully understood. The aim of the present study was to evaluate ‐mediated anti‐oxidation by focusing anti‐oxidase and mitochondrial biogenesis in rats after myocardial infarction MI ). Sprague–Dawley were divided into three groups: (i) a sham‐operated control CON ); (ii) an group; (iii) + group. Myocardial microstructure function, markers oxidative...
Oxidative stress serves a critical role in melanocyte death and is considered to be major cause of vitiligo. The nuclear factor E2‑related 2 (Nrf2) signaling pathway has an important the antioxidative mechanisms melanocytes. Glycyrrhizin (GR) derivative herbal medicines used treat hepatitis allergic disease due its antiviral anti‑allergy effects. GR also activates Nrf2 induces expression heme oxygenase (HO)‑1 macrophages. Whether can protect human melanocytes from oxidative remains unknown....
Abstract Oxidative stress leads to melanocyte death and has been implicated in the pathogenesis of vitiligo. The nuclear factor, E2‐related factor 2 (Nrf2), is a critical transcription protecting cells from oxidative damage. High‐mobility group box 1 ( HMGB 1) chromatin‐associated protein an extracellular damage‐associated molecular pattern molecule. Extracellular released activated immune cells, necrotic or injured becomes proinflammatory mediator through binding cell‐surface receptors...
Roux-en-Y gastric bypass surgery (RYGB) has been demonstrated to be successful for treating type-II diabetes mellitus (T2DM) patients with a body mass index (BMI) <30 kg/m(2), but reports of RYGB T2DM BMI <28 kg/m(2) are lacking. were prospectively recruited participate in this study four hospitals. The endpoint was remission (defined by fasting blood glucose (FBG) level <110 mg/dL and hemoglobin (Hb)A1c <6.0% at 12 months postoperatively). Predictors investigated univariate multivariate...
To investigate the potential mechanism and molecular characteristics of linezolid-non-sensitive Enterococcus faecium from a tertiary hospital in southwest China characterize relevant plasmids.Linezolid-non-sensitive (LNSEFM) isolates collected January 2014 to December 2018 were screened for resistant genes 23s rRNA, rplC, rplD, rplV, optrA, cfr, poxtA, by PCR. Molecular epidemiological analysis was performed multilocus sequence typing (MLST). The optrA-and-poxtA co-harboring strain EFM_7150...
Abstract Background In recent years, multiple coagulation and fibrinolysis (CF) indexes have been reported to be significantly related the progression prognosis of some cancers. Objective The purpose this study was comprehensively analyze value CF parameters in prediction pancreatic cancer (PC). Methods preoperative data, clinicopathological information, survival data patients with tumor were collected retrospectively. Mann Whitney U test, Kaplan-Meier analysis, Cox proportional hazards...
Overexpression or activation of Yes-associated protein (YAP) is common in cancer cells. Thus, targeting YAP may be a strategy for therapy. Licochalcone A (LicA) primary active compound licorice root and known to have medicinal effects, such as antioxidant, antibacterial, antiviral, anticancer effects. However, the pharmacological mechanism LicA has not been investigated cholangiocarcinoma. In this study, we antiproliferative effect underlying molecular HCCC-9810 RBE human cholangiocarcinoma...
Purpose: Omicron, a variant of COVID-19, is becoming major issue global concern. Its high transmissibility may bring challenges to the distribution health care in large population country like China. Investigating behavior virus Chinese will certainly help plan for upcoming surge Omicron. Therefore, we made preliminary analysis clinical and epidemiological characteristics suspected cases Omicron at early stage surge. Patients Methods: The study was conducted Nanyang Central Hospital,...
Abstract This research theoretically and empirically studies China's labor market integration the effect of economic openness. We introduce an open parameter to previous theoretical framework and, based on that, we carry out empirical study measurement from 1987 2006, focus impact Research indicates that openness has obvious promoting integration. The progress differs between regions, with markets coastal areas such as North China, East China South which have one or two centers, being better...
It has been reported that loss of Hugl-2 contributes to tumour formation and progression in vitro vivo. However, whether levels decrease during kidney renal clear cell carcinoma (KIRC) the mechanism involved remain unknown. This study aimed investigate DNA methylation reduces its expression, leading poor prognosis KIRC. mRNA expression KIRC clinicopathological data were extracted from The Cancer Genome Atlas (TCGA), relationships among these factors analyzed using UALCAN, MethHC, Wanderer...
Marxist humanism, inclusive and profound, is a complete ideological system that runs through his philosophy, political economics, scientific socialism other works as principal line. It an indispensable part of Marxism. humanism not in born but developed from embryo to maturity, during which Marx surpass previous thoughts by inheriting the theories critically. To interpret form concrete practical prospective have full deep understanding it great significance studying implementation our...
Objective: To explore the clinical effect of a novel artery first and uncinate process approach for laparoscopic pancreaticoduodenectomy(LPD), emphasizing left lateral posterior dissection (UP) via Treitz ligament approach. Methods: From April to November 2016, 18 patients received LPD with in Pancreas Center First Affiliated Hospital Nanjing Medical University. All were diagnosed as pancreatic head or peri-ampulla tumor, without major vessel invasion nor distant metastasis. For resection,...