A5076822031- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Pain Mechanisms and Treatments
- Nanoplatforms for cancer theranostics
- Neuroscience and Neuropharmacology Research
- Effects and risks of endocrine disrupting chemicals
- ATP Synthase and ATPases Research
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Luminescence and Fluorescent Materials
- Bariatric Surgery and Outcomes
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Anesthesia and Neurotoxicity Research
- Advanced biosensing and bioanalysis techniques
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- Circular RNAs in diseases
- Liver physiology and pathology
- Diabetes Treatment and Management
- Diabetes Management and Research
- Hepatocellular Carcinoma Treatment and Prognosis
Air Force Medical University
2015-2025
Yan'an University
2017-2025
Xijing Hospital
2011-2025
Peking University
2012-2024
Third Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2024
Peking University First Hospital
2012-2024
Nanjing University
2022-2023
Beijing University of Chinese Medicine
2023
Huzhou University
2022
<h3>Importance</h3> The gastric cancer (GC)–associated long noncoding RNA1 (lncRNA-GC1) plays an important role in carcinogenesis. However, exosomal lncRNA-GC1 and its potential GC are poorly understood. <h3>Objective</h3> To evaluate the diagnostic value of circulating for early detection monitoring progression GC. <h3>Design, Setting, Participants</h3> We performed a multiphase investigation involving consecutive patients with (n = 522), precancerous lesions 85), healthy donor individuals...
Chemiluminescence (CL) sensing without external excitation by light and autofluorescence interference has been applied to high-contrast in vitro immunoassays vivo inflammation tumor microenvironment detection. However, conventional CL usually operates the range of 400-850 nm, which limits performance imaging due serious scattering effects signal attenuation tissue. To address this challenge, a new type sensor is presented that functions second near-infrared window (NIR-II CLS) with deep...
Abstract Oxidative stress plays a crucial role in the pathogenesis of hepatic encephalopathy (HE), but mechanism remains unclear. GABAergic neurons substantia nigra pars reticulata (SNr) contribute to motor deficit HE. The present study aims investigate effects oxidative on HE male mice. results validate existence both liver and SNr across two murine models induced by thioacetamide (TAA) bile duct ligation (BDL). Systemic mitochondria-targeted antioxidative drug mitoquinone (Mito-Q) rescues...
Over the past few years, significant efforts have been made to create new fluorescent probes operating at longer wavelengths, particularly in second near-infrared (NIR-II) window from 1000 1700 nm, offering enhanced tissue penetration compared light visible and first (700-900 nm). However, most of reported NIR-II fluorophores meet such dilemmas; they are excreted slowly largely retained within reticuloendothelial system. Here, we report a rapidly lanthanide complex Nd-DOTA (over 50% through...
Abstract Chemiluminescence (CL) is a very promising method for applications in analytic chemistry and biological systems due to the elimination of external light source, which could reduce autofluorescence interference improve signal‐to‐noise ratio (SNR) tissue penetration depth. The fluorescent dyes, chemiluminescent initiator, reaction temperature are three crucial factors that determine chemiluminescence efficiency. Up now, significant development probes has been reported high‐performance...
Mitochondria play an essential role in pathophysiology of both inflammatory and neuropathic pain (NP), but the mechanisms are not yet clear. Dynamin-related protein 1 (Drp1) is broadly expressed central nervous system plays a induction mitochondrial fission process. Spared nerve injury (SNI), due to dysfunction neurons within spinal dorsal horn (SDH), most common NP model. We explored neuroprotective Drp1 SDH SNI. SNI mice showed behavior anxiety-like behavior, which was associated with...
<title>Abstract</title> <bold>Background:</bold> Neuropathic pain has been shown to induce abnormal mitochondrial fission in neurons, yet the analgesic potential of inhibiting this process remains unclear. Our previous studies demonstrated that targeted regulation dynamin-related protein (DRP1) can alleviate neuropathic pain; however, downstream molecular signaling mechanisms remain be elucidated. <bold>Methods:</bold> To investigate role dynamics pain, we utilized C57BL/6J mice, GAD2-Cre...
<title>Abstract</title> Although neuropathic pain leads to abnormal mitochondrial fission in neurons, it remains unclear whether inhibiting has analgesic effects. This study focused on protein 1 (FIS1) investigate its role spared nerve injury (SNI)-induced and the underlying mechanisms. Using MiNA analysis, electron microscopy, membrane potential (MMP), reactive oxygen species (ROS), adenosine triphosphate (ATP) detection, we observed that networks both excitatory inhibitory neurons of...
Cerebellar ataxia is the primary manifestation of cerebellar degenerative diseases, and mitochondrial dysfunction in Purkinje cells (PCs) plays a critical role disease progression. In this study, we investigated feasibility mitochondria transplantation as potential therapeutic approach to rescue neurodegeneration elucidate associated mechanisms. We constructed conditional Drp1 knockout model PCs (PCKO mice), characterized by progressive ataxia. resulted pervasive apoptosis significant...
<title>Abstract</title> Neurodegenerative diseases refer to a group of clinical conditions characterized by progressive neuronal loss, resulting in impaired brain structural integrity and functional abnormalities. These can lead widespread cerebrovascular remodeling; however, the spatial remodeling features capillaries with diameters ≤ 10 μm remain poorly understood, particularly regard changes relationship between neurons capillaries. In this study, we first developed double-fluorescent...
The shortage of donors is a major challenge for transplantation; however, organs from genetically modified pigs can serve as ideal supplements1,2. Until now, porcine hearts and kidneys have been successively transplanted into humans3–7. In this study, heterotopic auxiliary transplantation was used to donate six-gene-edited pig liver brain-dead recipient. graft function, haemodynamics, immune inflammatory responses the recipient were monitored over subsequent 10 days. Two hours after portal...