A5075156506- Tuberculosis Research and Epidemiology
- Cancer Immunotherapy and Biomarkers
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- RNA Interference and Gene Delivery
- Bacterial Identification and Susceptibility Testing
- Cancer Genomics and Diagnostics
- Advanced oxidation water treatment
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Bacterial biofilms and quorum sensing
- CAR-T cell therapy research
- Circular RNAs in diseases
- Advanced Photocatalysis Techniques
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Cell death mechanisms and regulation
- Antibiotic Use and Resistance
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Hemophilia Treatment and Research
- Pharmacological Effects of Natural Compounds
- Gut microbiota and health
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
Xijing Hospital
2016-2025
Second Hospital of Shandong University
2024-2025
Air Force Medical University
2016-2025
Wuhan Sports University
2025
Hohai University
2022-2025
Nanjing Medical University
2024
Jiangsu Province Hospital
2020-2024
East China Normal University
2024
Northeastern University
2021-2023
Nanjing University of Chinese Medicine
2017-2023
Abstract In patients with prostate cancer (PCa), bone lesions appear osteoblastic in radiographs; however, pathological fractures frequently occur PCa patients, and resorption is observed all metastatic under histopathologic assessment. The mechanisms that balance the activities of osteoblasts osteoclasts remain unclear. We unexpectedly discovered exosomes are critical mediators regulation homeostasis results osteoclastic thereby promotes tumor growth bone. evaluated how derived from...
Aberrations in epigenetic processes, such as histone methylation, can cause cancer. Retinoblastoma binding protein 2 (RBP2; also called JARID1A or KDM5A) demethylate tri- and dimethylated lysine 4 H3, which are marks for transcriptionally active chromatin, whereas the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor promotes H3K4 methylation. Previous studies suggested that inhibition of RBP2 contributed to suppression by retinoblastoma (pRB). Here, we show genetic ablation Rbp2...
The three EglN prolyl hydroxylases (EglN1, EglN2, and EglN3) regulate the stability of HIF transcription factor. We recently showed that loss however, also leads to down-regulation Cyclin D1 decreased cell proliferation in a HIF-independent manner. Here we report EglN2 can hydroxylate FOXO3a on two specific residues vitro vivo. Hydroxylation these sites prevents binding USP9x deubiquitinase, thereby promoting proteasomal degradation FOXO3a. FOXO factors repress transcription. Failure...
Tuberculous meningitis leads to a devastating outcome, and early diagnosis rapid chemotherapy are vital reduce morbidity mortality. Since Mycobacterium tuberculosis is kind of cytozoic pathogen its numbers very few in cerebrospinal fluid, detecting M. fluid from tuberculous patients still challenge for clinicians. Ziehl-Neelsen stain, the current feasible microbiological method tuberculosis, often needs large amount specimen but shows low detection rate tuberculosis. Here, we developed...
T lymphocytes infiltrate the microenvironment of breast cancer tumors and play a pivotal role in tumor immune surveillance. Relationships between T-cell receptors (TCR) borne by cells within tumors, surrounding tissues, draining lymph nodes are largely unexplored human cancer. Consequently, information about relative extent possible exchange these tissues is also lacking. Here, we have analyzed TCR repertoire using multiplex PCR high-throughput sequencing TCRβ chain tumor, adjacent nontumor,...
Although drug resistance in Mycobacterium tuberculosis is mainly caused by mutations activating enzymes or targets, there increasing interest the possible role of efflux causing resistance. Previously, genes have been shown to be upregulated upon exposure implicated overexpression studies, but pumps identified clinical isolates unknown. Here we investigated pump Rv1258c (Tap) from M. tuberculosis. We constructed point V219A and S292L chromosome were confirmed DNA sequencing. The...
Dermatosis neglecta (DN) is a rare condition, often linked to psychosomatic disorders, with an unclear etiology. Chilblain lupus erythematosus (CHLE) constitutes variant of cutaneous erythematosus, frequently mistaken for idiopathic chilblain due its chilblain-like lesions. To date, no instances concurrent DN and CHLE occurring at the site skin flap or graft have been documented. Herein, we present case that occurrence developed on once. The simultaneous exceptionally rare. Clinicians must...
Background/Objectives: Early diagnosis and treatment of rheumatoid arthritis (RA) are essential to reducing disability. However, the diagnostic criteria remain unclear, relying on clinical symptoms blood markers. Methods: Using high-performance liquid chromatography–mass spectrometry (HPLC-MS/MS) targeted detection, we evaluated 76 carnitine indicators (55 carnitines 21 corresponding ratios) in serum patients with RA investigate role RA. A total 359 (207 152 healthy controls) were included...
Although late-life remarriage is not a rare phenomenon, it remains controversial topic in China. Late-life involves many challenges and crises, especially for elderly women, who are often weaker positions relationships face more difficulties. Currently, research on the life experiences of Chinese women after still limited. The purpose this study to explore describe remarried later their feelings about these experiences. A phenomenological qualitative design involving in-depth semistructured...
The shortage of donors is a major challenge for transplantation; however, organs from genetically modified pigs can serve as ideal supplements1,2. Until now, porcine hearts and kidneys have been successively transplanted into humans3–7. In this study, heterotopic auxiliary transplantation was used to donate six-gene-edited pig liver brain-dead recipient. graft function, haemodynamics, immune inflammatory responses the recipient were monitored over subsequent 10 days. Two hours after portal...
Rationale: Early diagnosis and treatment of tuberculous meningitis saves lives, but current laboratory diagnostic tests lack sensitivity.Objectives: We investigated whether the detection intracellular bacteria by a modified Ziehl-Neelsen stain early secretory antigen target (ESAT)-6 in cerebrospinal fluid leukocytes improves diagnosis.Methods: Cerebrospinal specimens from patients with suspected were stained conventional stain, involving cytospin slides Triton processing, an ESAT-6...
Circulating cell-free DNA (cfDNA) fragmentomics, which encompasses the measurement of cfDNA length and short nucleotide motifs at ends molecules, is an emerging field for cancer diagnosis. The utilization fragmentomics diagnosis patients with hepatocellular carcinoma (HCC) caused by hepatitis B virus (HBV) currently limited. In this study, we utilized whole-genome sequencing data in samples from HCC (n = 197) HBV 187) to analyze association fragment size selection (< 150 bp) tumor fraction...
Background Patients with ulcerative colitis (UC) are at an increased risk of developing Clostridioides difficile infection (CDI), which in turn leads to poor outcomes. The gut microbial structure and metabolites patients UC CDI have been scarcely studied. We hypothesized that changes the microbiota UC. Materials Methods This study included 89 patients: 30 healthy controls (HC group), 29 alone (UCN (UCP group). None participants has exposed antibiotic treatments during 3 months before stool...