A5100660799- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cloud Computing and Resource Management
- Advanced Combustion Engine Technologies
- IoT and Edge/Fog Computing
- Cancer Research and Treatments
- Graphene and Nanomaterials Applications
- Reproductive System and Pregnancy
- RNA modifications and cancer
- RNA Research and Splicing
- Combustion and flame dynamics
- Plant Surface Properties and Treatments
- Software System Performance and Reliability
- Neonatal and fetal brain pathology
- Effects and risks of endocrine disrupting chemicals
- Autophagy in Disease and Therapy
- Carbon and Quantum Dots Applications
- Catalytic Processes in Materials Science
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gut microbiota and health
- Pregnancy and preeclampsia studies
- Barrier Structure and Function Studies
- Microfluidic and Bio-sensing Technologies
- Chronic Kidney Disease and Diabetes
Nanjing Medical University
2016-2025
Huazhong University of Science and Technology
2005-2024
First Affiliated Hospital of Jinan University
2019-2024
Jilin University
2022-2023
Jilin Medical University
2023
First Hospital of Jilin University
2022
Wuxi People's Hospital
2021
Soochow University
2021
First Affiliated Hospital of Soochow University
2021
Central Hospital of Zibo
2016-2021
The evaluation of the chemical impact on human health is usually constrained to analysis effects exposure a single or group similar chemicals at one time. mixtures are seldom analyzed. In this study, we applied three statistical models assess association between mixture seven xenobiotics (three phthalate metabolites, two phenols, and pesticides) obesity. Urinary levels environmental pesticides, metabolites were measured in adults who participated U.S.-based National Health Nutrition...
Emerging evidence suggests that the long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) gene is involved in pathogenesis of cervical cancer. However, potential mechanism rarely reported. Our study found PVT1 was upregulated cancer tissue and cell lines. After transfecting siRNA, proliferation, migration, invasion cells were markedly decreased. miRNA expression profiles demonstrate miR-424 downregulated tissue. Bioinformatics analysis revealed potentially targeted by PVT1,...
Enhancer RNAs (eRNAs) are a group of lncRNAs transcribed from enhancers, whose regulatory effects on gene expression an emerging area interest. However, the role eRNAs in regulating trophoblast cells and unexplained recurrent pregnancy loss (URPL) remains elusive.We profiled villi URPL patients matched controls by RNA-seq. Functions URPL-related were further investigated vitro.We identified lnc-SLC4A1-1, which was active enhancer marked with H3K27ac H3K4me1 so-called eRNA, highly expressed...
Abstract Di‐(2‐ethylhexyl) phthalate (DEHP) is one of the most commonly used plasticizers, and it widely applied in various plastic products. DEHP an endocrine‐disrupting chemical (EDC) that has been shown to disrupt function reproductive system females. Although many studies have potentially causes female toxicity, including depletion primordial follicle decreased sex hormone production, specific mechanisms by which affects reproduction remain unknown. In recent years, research focused on...
Chemotherapy resistance is identified as an obstacle for breast cancer (BC) therapy, and, besides, increasing evidence indicates that long-noncoding RNAs (lncRNAs) participate in the regulation of BC adriamycin (ADR) resistance. Here, our work shows lncRNA DLGAP1 antisense RNA 1 (DLGAP1-AS1) up-regulated ADR-resistant cells (MCF-7/ADR). Clinically, higher DLGAP1-AS1 expression was closely correlated to poorer clinical prognosis. Results showed promoted ADR IC
Circulating cell-free DNA (cfDNA) fragmentomics, which encompasses the measurement of cfDNA length and short nucleotide motifs at ends molecules, is an emerging field for cancer diagnosis. The utilization fragmentomics diagnosis patients with hepatocellular carcinoma (HCC) caused by hepatitis B virus (HBV) currently limited. In this study, we utilized whole-genome sequencing data in samples from HCC (n = 197) HBV 187) to analyze association fragment size selection (< 150 bp) tumor fraction...
Icaritin, a hydrolytic product of icariin from the Epimedium genus, exerts anti-tumour effects on variety tumour cell types, mainly by inhibiting proliferation and inducing apoptosis. However, little is known about role icaritin in cancer invasion epithelial-to-mesenchymal transition (EMT). In present study, glioblastoma (GBM) line U87MG was used as model to investigate EMT cells. The results showed that significantly inhibited GBM cells targeting extracellular matrix metalloproteinase...
Modern large-scale cloud platforms require live migration technique on Docker containers with stateful workload to support load balancing, host maintenance, and Quality of Service (QoS) improvement. Efficient scalable is expected guarantee the component-integrity (image, runtime, management context) negligible downtime. In this paper, we present a highly efficient system called Sledge, which ensures by integrating both images context during runtime migration. The key insight that layered...
The immunosuppressive facet and tumorigenic role of TNF-α have been revealed in osteosarcoma (OS). Long noncoding RNA THRIL is identified to regulate expression participates immune response. Thus, investigations on the clinical pattern THRIL/TNF-α signal OS would provide a potential target premise for patients.We collected (n=83), nontumor tissues (n=37) serum samples (n=83 n=40 healthy control) determine expressions significance signal. Knockdown cell lines MG63 Saos2 vitro vivo was...
Numerous studies have indicated an important function of microRNAs (miRs) in breast cancer (BC) progression, oncogenesis and metastasis. However, the miR-3677, which has been revealed to be upregulated BC [The Cancer Genome Atlas (TCGA) data], not investigated date. In present study, miR-3677 was as determined using TCGA. significantly tissues cell lines compared with those noted adjacent non-cancerous primary normal cells (P<0.05). The overexpression promoted proliferation, migration...
Tight junctions rarely exist in podocytes of the normal renal glomerulus, whereas they are main intercellular nephrosis and early stage development. Claudins have been identified as tight junction-specific integral membrane proteins. Those podocytes, however, remain to be elucidated. In present study, we investigated expression localization claudin-6 rat kidney, especially podocytes. Western blot analysis RT-PCR revealed that neonatal kidney expressed much higher levels than adult kidney....
Radioresistance represents a major obstacle in cancer treatment, the underlying mechanism of which is complex and not well understood. miR-148b has been reported to be implicated regulating radioresistance lymphoma cells. However, this function investigated lung Microarray analysis was performed A549 cells 48 h after exposure 8 Gy γ-irradiation or sham irradiation identify differentially expressed miRNAs. mimic inhibitor were transfected, followed by clonogenic survival assay examine...
Gallbladder carcinoma (GBC) is the seventh most common cancer across globe and malignancy of biliary tract. Epithelial-mesenchymal transition (EMT) an important pre-requisite for tumor metastasis; however, its mechanism in GBC has not yet been defined. In present study, we investigated effects interleukin-37 (IL-37) on epithelial-mesenchymal gallbladder cells.RT-qPCR Western blotting were used to determine expression IL-37 cells non-tumorigenic human intra-hepatic epithelial cell line. was...
Despite increasing knowledge on oral and esophageal squamous cell carcinoma (OSCC ESCC), specific medicines against both have not yet been developed. Here, we aimed to find novel anticancer drugs through functional cell-based screening of an FDA-approved drug library OSCC ESCC. Pitavastatin, HMGCR inhibitor, emerged as that inhibits tumor growth by downregulating AKT ERK signals in ESCC cells. One the mechanisms which pitavastatin might be suppression MET signaling immature due dysfunction...
Large Language Models (LLMs) have demonstrated impressive capabilities in autogenerating code based on natural language instructions provided by humans. We observed that the microservice models of edge computing, problem deployment latency optimization can be transformed into an NP-hard mathematical problem. However, real world, strategies at often require immediate updates, while human-engineered tends to lagging. To bridge this gap, we innovatively integrated LLMs decision-making process...
Backgrounds: Enhancer RNAs (eRNAs) are subsets of lncRNAs and transcribed from enhancers, whose regulatory effects on gene expressions an emerging area interest. However, the roles eRNAs in regulating trophoblates unexplained recurrent pregnancy loss (URPL), still remain elusive.