A5100386065- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Barrier Structure and Function Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Antifungal resistance and susceptibility
- Alzheimer's disease research and treatments
- interferon and immune responses
- Tryptophan and brain disorders
- Extracellular vesicles in disease
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Carbon and Quantum Dots Applications
- Advanced Nanomaterials in Catalysis
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Mesenchymal stem cell research
- Histone Deacetylase Inhibitors Research
- Nanoparticle-Based Drug Delivery
- S100 Proteins and Annexins
China Pharmaceutical University
2015-2025
State Key Laboratory of Natural Medicine
2016-2025
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2018-2025
Southeast University
2015-2025
Central South University
2025
Medicina
2025
Chongqing Emergency Medical Center
2024
Chongqing University
2024
Peking University
2021-2023
Peking University People's Hospital
2021-2023
Abstract Many risk genes for the development of Alzheimer’s disease (AD) are exclusively or highly expressed in myeloid cells. Microglia dependent on colony-stimulating factor 1 receptor (CSF1R) signaling their survival. We designed and synthesized a selective brain-penetrant CSF1R inhibitor (PLX5622) allowing extended specific microglial elimination, preceding during pathology development. find that 5xFAD mouse model AD, plaques fail to form parenchymal space following depletion, except...
Abstract A new synergistic treatment that combines photothermal therapy (PTT) and inflammation‐mediated active targeting (IMAT) chemotherapy based on cytopharmaceuticals is developed. During PTT, the tumor ablation accompanied by an inflammatory effect upregulation of factors at site, which may accelerate regeneration. Moreover, PTT‐induced inflammation can also recruit neutrophils (NEs) to site. To convert disadvantages into strengths, NEs are investigated as for IMAT further inhibit...
Opioids have been widely applied in clinics as one of the most potent pain relievers for centuries, but their abuse has deleterious physiological effects including immunosuppression. However, mechanisms are unclear. TLRs and acetylcholine expressed immune nervous systems, play critical roles responses. In this article, we show that morphine suppresses innate immunity microglia bone marrow-derived macrophages through differential regulation acetylcholinesterase. Either or inhibition...
Intestinal toxicity induced by chemotherapeutics has become an important reason for the interruption of therapy and withdrawal approved agents. In this study, we demonstrated that chemotherapeutics-induced intestinal damage were commonly characterized sharp upregulation tryptophan (Trp)−kynurenine (KYN)−kynurenic acid (KA) axis metabolism. Mechanistically, chemotherapy-induced triggered formation interleukin-6 (IL-6)−indoleamine 2,3-dioxygenase 1 (IDO1)−aryl hydrocarbon receptor (AHR)...
Rationale: Despite considerable advances, the reactive oxygen species (ROS)-mediated cancer treatment suffers from problems of up-regulation adaptive antioxidants in cells as well side effects to normal cells. Therefore, development a new generation cancer-specific nanomedicine capable amplifying oxidative stress would be great interest for accurate and effective treatment. Methods: Herein, transferrin (Tf)-decorated, dihydroartemisinin (DHA), L-buthionine-sulfoximine (BSO), CellROX-loaded...
The ability to selectively block the entry of leukocytes into central nervous system (CNS) without compromising immune is an attractive therapeutic approach for treating multiple sclerosis (MS). Using endothelial CD146-deficienct mice as a MS model, we found that CD146 plays active role in CNS-directed extravasation encephalitogenic T cells, including CD146+ TH1 and TH17 lymphocytes. Moreover, both passive models with anti-CD146 antibody AA98 significantly decreased infiltrated lymphocytes...
Abstract Nanocarrier‐mediated codelivery of multiple anticancer drugs is a potential strategy for enhanced efficacy combination cancer treatment by unifying differential pharmacokinetic properties and maintaining an optimal ratio drug cargoes. However, programmable system highly desired to deliver different therapeutics their specific sites action pursue maximized combinational effect. Herein liposome‐based nanoassembly (p53/C‐rNC/L‐FA) developed intracellular site‐specific delivery...
Antibody-based therapeutics, which induce apoptosis of malignant cells by selectively binding to their receptors, hold tremendous promise for clinical cancer therapy. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has received considerable interest due its favorable capability activating in interacting with death receptors (DRs). However, stem-like (CSCs) show deficient or lower DR and are highly resistant TRAIL-mediated limiting the therapeutic efficacy. Here, we report a...
Copper (Cu) is a global environmental pollutant that poses serious threat to humans and ecosystems. induces developmental neurotoxicity, but the underlying molecular mechanisms are unknown. Neurons nonrenewable, they unable mitigate excessive accumulation of pathological proteins organelles in cells, which can be ameliorated by autophagic degradation. In this study, we established an vitro model Cu2+-exposed (0, 15, 30, 60 120 μM) SH-SY5Y cells explore role autophagy copper-induced...
ABSTRACT Aims Although previous studies have revealed the association between chronic pain‐induced depression and defective adult hippocampal neurogenesis (AHN), underlying molecular mechanism remains elusive. This study aims to examine AHN depression‐like behaviors, reveal mechanisms. Methods The neuropathic pain model was established using mice with spared nerve injury (SNI) surgery. behaviors were evaluated by sucrose preference test (SPT), tail suspension (TST), forced swimming (FST),...
Prostate cancer (PCa) remains a prevalent malignancy in men and warrants novel efficacious therapy. Protein arginine methyltransferase 7 (PRMT7) has been recently identified as promising target for PCa treatment, however, the development of PRMT7 inhibitors is limited. Herein, we reported an effective selective inhibitor, A33, which was obtained through structural optimization exhibited potent anti-PCa efficacy vitro vivo. A33 significantly inhibited proliferation, colony formation,...
Matrix metalloproteinase-9 (MMP-9) and matrix metalloproteinase-2 (MMP-2) play important roles in the progression of renal interstitial fibrosis (RIF). There is an increasing demand to construct a novel method for simultaneous detection MMP-9 MMP-2 monitor RIF. Herein, strategy based on nanoplatform composed polydopamine nanosphere fluorescence-labeled aptamers developed simultaneously detect with DNase-I-assisted recycling signal amplification. In light tracing recovered fluorescence...
Cisplatin is a chemotherapeutic agent widely employed in the treatment of various solid tumors. However, its use often restricted by acute kidney injury (AKI) which dose-limiting adverse effect cisplatin. While numerous studies aiming to alleviate AKI have been conducted, there are no effective remedies clinical practice. In this paper, targeted metabolomics study was performed reveal potential relationship between tryptophan metabolism and cisplatin-induced AKI. A chemical derivatization...
San Hua Tang (SHT) was first mentioned in the book "The Collection of Plain Questions about Pathogenesis, Qi, and Life." SHT has effect dispelling wind dredging collaterals, viscera, guiding stagnation, is used treatment ischemic stroke (IS). composed Rheum palmatum L., Magnolia officinalis Rehder & E.H.Wilson, Citrus assamensis S.Dutta S.C.Bhattacharya, Notopterygium tenuifolium M.L.Sheh F.T.Pu, which traditional prescription Tongxia method for stroke. one "eight methods" Chinese medicine,...
Abstract A novel and sensitive method for the determination of ceftazidime cefepime in an active pharmaceutical ingredient (API) has been developed based on fluorescence quenching poly(ethylene glycol) (PEG)2000‐capped carbon quantum dots (CQDs) prepared using a chemical oxidation method. The intensity is proportional to concentration over range 0.33–3.30 0.24–2.40 µg/mL, respectively. mode interaction between PEG2000‐capped CQDs ceftazidime/cefepime aqueous solutions was investigated...
Paeoniflorn (PF), the principal bioactive component of Paeoniae radix prescribed in traditional Chinese medicine, possesses a wide range biological effects and exhibits neuroprotective numerous diseases. Previous studies have demonstrated that PF significantly attenuates memory impairment rats with vascular dementia (VD). In present study, bilateral common carotid artery occlusion (BCCAO) rat model was used to explore underlying mechanisms PF. The expression levels neuron-specific enolase...