A5082257904- Receptor Mechanisms and Signaling
- Cancer, Stress, Anesthesia, and Immune Response
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- Cytokine Signaling Pathways and Interactions
- Nuclear Receptors and Signaling
- Immune Cell Function and Interaction
- Advanced biosensing and bioanalysis techniques
- Tryptophan and brain disorders
- NF-κB Signaling Pathways
- Sirtuins and Resveratrol in Medicine
- Bioactive Compounds and Antitumor Agents
- Cardiac Ischemia and Reperfusion
- Diabetes and associated disorders
- Ion Channels and Receptors
Shandong First Medical University
2024
Second Affiliated Hospital of Zhejiang University
2021-2022
Central South University
2016-2021
East Tennessee State University
2009-2020
Tennessee State University
2016-2020
Shandong University
2005
American Red Cross
1998-2003
Changsha Medical University
1998
Depending on the duration and severity, psychological tension physical stress can enhance or suppress immune system in both humans animals. Although it is well established that alters release of various hormones neurotransmitters, mechanisms by which affects responses remain elusive. We report here mice subjected to chronic 12-hour daily restraint for two days exhibited a significant reduction splenocytes, process likely mediated apoptosis as demonstrated terminal deoxynucleotidyl...
Abstract Metastin, the gene product of metastasis suppressor KiSS‐1, is endogenous ligand for G‐protein‐coupled receptor GPR54 (or AXOR12, or OT7T175). The expression KiSS‐1 and peptide distribution metastin were studied in rat central nervous system by reverse transcriptase‐polymerase chain reaction, Western blotting, immunohistochemical methods. was higher hypothalamus than brainstem spinal cord. In brain, metastin‐like immunoreactivity (irMT) found mainly three groups cells: dorsomedial...
Context: GLUT4 is the predominant glucose transporter isoform expressed in fat and muscle. In null mice, insulin-stimulated uptake into muscle was diminished but not eliminated, suggesting that another insulin-sensitive system present. Objective: This study intended to determine whether insulin caused GLUT12 translocation Design: Six normal volunteers had biopsies before after euglycemic infusions. Setting: Infusions were performed an outpatient clinic. Participants: Subjects nonobese, young...
Opioids have been widely applied in clinics as one of the most potent pain relievers for centuries, but their abuse has deleterious physiological effects including immunosuppression. However, mechanisms are unclear. TLRs and acetylcholine expressed immune nervous systems, play critical roles responses. In this article, we show that morphine suppresses innate immunity microglia bone marrow-derived macrophages through differential regulation acetylcholinesterase. Either or inhibition...
Cardiac dysfunction is correlated with detrimental prognosis of sepsis and contributes to a high risk mortality. After an initial hyperinflammatory reaction, most patients enter protracted state immunosuppression (late sepsis) that alters both innate adaptive immunity. The changes cardiac function in late are not yet known. MicroRNA-155 (miR-155) previously found play important roles regulations immune activation function. In this study, C57BL/6 mice were operated develop into early phases,...
In the past few years, 8 additional members of facilitative hexose transporter family have been identified, giving a total 14 SLC2A membrane-bound transporters. To determine which new transporters were expressed in muscle, mRNA concentrations 11 glucose (GLUTs) quantified and compared. RNA from muscle 10 normal volunteers was subjected to RT-PCR. Primers designed that amplified 78- 241-base fragments, cDNA standards cloned for GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9, GLUT10,...
The control of IL-10 production in Toll-like receptor (TLR) signals remains to be elucidated. Here, we report that β-arrestin 2 positively regulates TLR-triggered a p38 mitogen-activated protein kinase (MAPK)-dependent mechanism. In vitro studies with cells including peritoneal macrophages and HEK293/TLR4 have demonstrated forms complexes facilitates activation after lipopolysaccharide (LPS) stimulation. Deficiency inhibition MAPK activity both ameliorate TLR4-stimulated response....
Myocardial infarction (MI), characterized by ischemia-induced cardiomyocyte apoptosis, is the leading cause of mortality worldwide. NR4A2, a member NR4A orphan nucleus receptor family, upregulated in mouse hearts with MI injury. Furthermore, NR4A2 knockdown aggravates heart injury as evidenced enlarged and increased apoptosis. To elucidate underlying mechanisms NR4A2-regulated we used H9c2 cardiomyocytes deprived serum neonatal rat (NRCMs) exposed to hypoxia mimic ischemic conditions vivo....
Ovarian cancer is the most common and lethal gynecological tumor in women worldwide. High-grade serous ovarian carcinoma (HGSOC) one of histological subtypes epithelial cancer, accounting for 70%. It often occurs at later stages associated with a more fatal prognosis than endometrioid carcinomas (EC), another subtype cancer. However, molecular mechanism biology underlying metastatic HGSOC (HG_M) immunophenotype remain poorly elusive. Here, we performed single-cell RNA sequencing analyses...
Abstract Fas (CD95/APO-1) is a transmembrane protein of the TNF/neuron growth factor receptor family. Ligation by specific Abs or ligand (FasL/CD95 ligand) induces rapid apoptotic cell death in variety types. Despite progress understanding signals transduced from Fas, very little known with regard to mechanisms which expression regulated. Using our previously established murine T hybridoma model A1.1, we show that kinase C (PKC) inhibitors could block activation-induced and apoptosis. The...
DNA methylation and histone modifications have emerged as key mechanisms in transcriptional regulation. The target of methylation-induced silencing 1 (TMS1) is a bipartite protein. Recent studies indicated that methylation-associated TMS1 occurs many cancers. However, whether how regulated by epigenetic cancers remains unknown. In this study we showed the promoter occurred five six hepatocellular carcinoma (HCC) cell lines. expression was reduced four HCC lines correlated with status....