microRNAs (miRNAs) are a class of small non‑coding RNAs that post-transcriptionally regulate gene expression. Increasing evidence has shown the deregulation miRNAs is linked to cancer. The overexpression miR-224 been reported in several human cancers. aim present study was investigate function pathogenetic process hepatocellular carcinoma (HCC), and precise mechanism underlying its function. Both gain-of-function loss-of assays were conducted through transfection with mimics inhibitors HepG2...

Ziziphi Spinosae Semen (ZSS), a medicinal food, is one of the most popular Chinese herbs, known for its rich bioactive ingredients, such as terpenoids and flavonoids. The content these ingredients in ZSS varies with age. However, distribution throughout developmental phases ZSS-white maturity (S1), firm ripening (S2), full (S3)-and within specific tissues like cotyledon, endosperm, radicle, has not yet been determined. This research aimed to analyze spatial key quality markers elucidate...

Extrahepatic cholangiocarcinoma (EHCC) is a refractory malignancy with poor prognosis due to its early invasion, metastasis and recurrence after operation. Therefore, understanding the mechanisms of invasion key development new effective therapeutic strategies for EHCC. In present study we demonstrated that miR-221 promoted EHCC through targeting PTEN formed positive feedback loop β-catenin/c-Jun signaling pathway. We found was upregulated in specimens CC cell lines. Moreover, strongly...

Recently, the visible-light photoredox decarboxylative couplings of N-(acyloxy)phthalimides (NHPI esters) and its derivatives have become an efficient chemical transformation. Under visible light, NHPI esters undergo a single-electron transfer (SET) process to afford corresponding carbon or nitrogen radicals that participate in many transformations. The been applied achieve construction array carbon–carbon carbon–heteroatom bonds as well synthesis carbocycles heterocycles. This review...

Arsenic trioxide (ATO) has been shown to induce hepatic injury. Crocetin is a primary constituent of saffron, which verified have antioxidant and anti-inflammatory effects. In the current experiment, we evaluated efficacy crocetin against ATO-induced injury explored potential molecular mechanisms in rats.Rats were pretreated with 25 or 50 mg/kg 6 h prior treating 5 ATO daily for 7 days.Treatment attenuated body weight loss, decreases food water consumption, improved pathological damage....

Background: Hesperidin (HES) is a flavonoid glycoside found in the tangerine peel and has antioxidant properties. Arsenic trioxide (ATO) an anti-tumour drug; however, its serious cardiotoxicity limits clinical application. In addition, protection of HES against ATO-induced not been explored. Objective: The study aims to investigate identify underlying effect mechanism on cardiotoxicity. Methods: Fifty mice were randomly assigned five groups. Mice orally given HES:100 or 300 mg/kg/day...

Hesperidin (HES) is an abundant and economical dietary bioflavonoid, it has several pharmacological properties such as antioxidant activity powerful cardiac protection. However, HES protection against cisplatin (CP)-induced cardiotoxicity its mechanism have not been fully clarified. The current study was performed to further elucidate the of CP-induced cardiotoxicity. Mice were orally administered (100 or 300 mg kg-1 day-1) for 7 consecutive days then injected intraperitoneally (i.p.) with...

Network pharmacology combines drug and disease targets with biological information networks based on the integrity systematicness of interactions between drugs targets. This study aims to explore molecular basis Hanshi Zufei formula for treatment COVID-19 network docking techniques. Using TCMSP, chemical constituents Atractylodis Rhizoma, Citri Reticulatae Pericarpium, Magnoliae Officinalis Cortex, Pogostemonis Herba, Tsaoko Fructus, Ephedrae Notopterygii Rhizoma et Radix, Zingiberis Recens,...

San Hua Tang (SHT) was first mentioned in the book "The Collection of Plain Questions about Pathogenesis, Qi, and Life." SHT has effect dispelling wind dredging collaterals, viscera, guiding stagnation, is used treatment ischemic stroke (IS). composed Rheum palmatum L., Magnolia officinalis Rehder & E.H.Wilson, Citrus assamensis S.Dutta S.C.Bhattacharya, Notopterygium tenuifolium M.L.Sheh F.T.Pu, which traditional prescription Tongxia method for stroke. one "eight methods" Chinese medicine,...

The study aimed to investigate the risk factors of postpancreatectomy hemorrhage (PPH) after pancreaticoduodenectomy (PD). A retrospective analysis 423 patients who underwent PD between January 2008 and 2014 was conducted. overall incidence all-cause mortality PPH were 9.9% (42/423) 2.1% (9/423), respectively. Independent early revascularization (odds ratio (OR) = 6.786; 95% confidence interval (95% CI): 1.785–25.792; <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...

Purpose: Magnesium isoglycyrrhizinate (MgIG), a single stereoisomer magnesium salt of glycyrrhizic acid, has beneficial effects on the cardiovascular system through anti-inflammatory, anti-oxidation, and anti-apoptotic actions. However, MgIG not been shown to provide protection against cardiotoxicity induced by arsenic trioxide (ATO). This study aims demonstrate ATO-induced cardiac toxicity in mice investigate underlying mechanism. Methods: A mouse model was established administering 5 mg/kg...

Abstract 18β‐Glycyrrhetinic acid (18β‐GA) is a component extracted from licorice. This study aimed to evaluate the effects of 18β‐GA on isoproterenol (ISO)‐induced acute myocardial infarction in rats and mice. Two consecutive days subcutaneous injection ISO (85 mg/kg/day) resulted infarction. We examined pathological changes, oxidative stress, inflammatory response, expression apoptosis mouse hearts. The expressions phosphoinositol‐3‐kinase (PI3K), protein kinase B (Akt), phosphorylation...

The dried roots of the Astragalus propinquus Schischkin (RAP) plant, as a traditional Chinese medicine, has been widely used to treat stroke, cerebral ischemia, qi deficiency, and hypertension. Buyang Huanwu decoction is traditionally stroke in China for more than 200 years significant effect on RAP monarch medicine decoction. Therefore, this study was designed observe regulatory transmembrane iron transporters ferroptosis-related factors ischemia-reperfusion injury (CIRI) rats.Middle artery...

Monoammonium glycyrrhizinate (MAG) is an aglycone of glycyrrhizin that found in licorice and often used clinically as injection to treat liver diseases. However, the effect MAG on cardiac function its possible cellular mechanisms remain unclear. We explored protective effects against myocardial ischemic injury (MII) induced by isoproterenol (ISO), well via molecular biology techniques patch-clamp recording.A rat model ischemia was administering ISO (85 mg/kg) subcutaneously for 2 consecutive...

Tannic acid (TA) is a class of complex water soluble polyphenolic derivatives, it shows anti-carcinogenic and anti-inflammatory activities eliminates the body's ability to form hydroxyl radicals. We studied TA's protective effects against isoproterenol (ISO) -induced myocardial fibrosis (MF) potential mechanisms in mice. Mice received TA ISO dosing were expend after 48 h later.The serum creatine kinase (CK) Lactate dehydrogenase (LDH) detected by ELISA assay. Cardiac histopathology was...

Abstract Ziziphi Spinosae Semen (ZSS) is the first choice for treatment of insomnia. This research aimed to reveal spatial distribution identifying quality markers ZSS and illustrate metabolite characteristics this herbal medicine. Here, we performed a matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) in situ detect image 33 metabolites ZSS, including three saponins, six flavonoids, four alkaloids, eight fatty acids, 12 amino acids. The MALDI images clearly...

is a kind of medicinal plant that has made great contribution to human health because the presence bioactive metabolites:

Manganese dioxide is typically reduced to a bivalent state before being extracted; here, sulfur considered an efficient reductant and sulfur–based reduction has been industrialized in China. In this study, the reaction mechanism between MnO2 gaseous was investigated. Thermodynamically, of by feasible. The predominant phase diagram as functions temperature input S2(g) fraction S2–MnO2 system calculated. Experimental validation showed that stepwise low-valence manganese oxides sulfate....