A5101868664- Multiple Myeloma Research and Treatments
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- Hepatitis C virus research
- Reproductive Biology and Fertility
- HIV/AIDS drug development and treatment
- Neurological Disease Mechanisms and Treatments
- Cancer Mechanisms and Therapy
- Flavonoids in Medical Research
- Immunodeficiency and Autoimmune Disorders
- RNA modifications and cancer
- Chemokine receptors and signaling
- Telomeres, Telomerase, and Senescence
- Plant Gene Expression Analysis
- Myasthenia Gravis and Thymoma
- Plant Physiology and Cultivation Studies
- Hepatitis B Virus Studies
- Gut microbiota and health
- Pneumocystis jirovecii pneumonia detection and treatment
- Medicinal Plant Pharmacodynamics Research
- Chronic Lymphocytic Leukemia Research
- Inflammatory Bowel Disease
Central South University
2010-2025
Xiangya Hospital Central South University
2011-2025
Shandong University of Technology
2024
Sanofi (United States)
2023
Xuzhou No.1 People's Hospital
2023
Xuzhou Medical College
2017-2023
Shenzhen University Health Science Center
2022-2023
University of Manchester
2023
Affiliated Hospital of Youjiang Medical University for Nationalities
2023
Harbin Medical University
2008-2022
Abstract Background In the last decade, studies in hepatocellular carcinoma (HCC) demonstrate dysregulation of miRNAs expression. For instance, miR‐650 has been implicated gastric and colorectal cancer tumorigenicity; however, role remains unknown HCC. Methods this study, we performed a comprehensive analysis to examine expression level 248 HCC 120 paracarcinomatous liver (PCL) tissues. The correlations between clinicopathological characteristics (HCC tumorigenicity) were evaluated. played...
This study investigates baicalin, a flavonoid from Scutellaria baicalensis, as multi-target therapeutic for type 2 diabetes mellitus (T2DM) through cellular experiments, network pharmacology, and molecular docking. Baicalin improves pancreatic β-cell viability, reduces reactive oxygen species (ROS), attenuates apoptosis/senescence in methylglyoxal (MGO)-induced models. Network pharmacology identifies key targets including HIF-1α, Bax, Bcl-2, Caspase-3, while docking confirms strong...
Long-term Helicobacter pylori infection leads to chronic gastritis, peptic ulcer, and gastric malignancies. Indigenous microflora in alimentary tract maintains a colonization barrier against pathogenic microorganisms. This study is aimed observe the duodenum alteration after H. Mongolian Gerbils model.A total of 18 gerbils were randomly divided into two groups: control group that given NCTC J99 strain intragastrically. After 12 weeks, was identified by rapid urease tests bacterial culture....
Involvements of microRNA-22 (miR-22) in cancer development have attracted much attention, but its role tumorigenesis gastric is still largely unknown. Therefore, the aim this study was to investigate expression patterns and clinical implications miR-22 cancer.Quantitative RT-PCR performed evaluate levels 98 pairs normal adjacent mucosa.Compared with mucosa, significantly downregulated tissues (P < 0.001). Of patients cancer, 58 (59.2%) were placed low group 40 (40.8%) high group. In...
The study aimed to investigate the risk factors of postpancreatectomy hemorrhage (PPH) after pancreaticoduodenectomy (PD). A retrospective analysis 423 patients who underwent PD between January 2008 and 2014 was conducted. overall incidence all-cause mortality PPH were 9.9% (42/423) 2.1% (9/423), respectively. Independent early revascularization (odds ratio (OR) = 6.786; 95% confidence interval (95% CI): 1.785–25.792; <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Ulcerative colitis (UC) is a chronic with unknown etiology. Circular RNA (circRNA) has shown regulatory effect in many diseases, but the role of circRNA UC barely known. This study uncovers function and mechanism HECTD1 (circHECTD1) UC.Colonic mucosal tissues 60 patients active 30 healthy controls were collected for H&E staining. Lipopolysaccharide (LPS) dextran sulfate sodium (DSS) used to induce inflammation Caco-2 cells C57BL/6 mice where modification circHECTD1, miR-182-5p and/or human...
Abstract This single‐center, open‐label, non‐randomized, two‐part, phase I study was conducted (1) to evaluate the absolute oral bioavailability of rilzabrutinib 400 mg tablet following an i.v. microtracer dose ~100 μg [14C]‐rilzabrutinib (~1 μCi) and single (part 1), (2) characterize absorption, metabolism, excretion (AME) 14C‐radiolabeled (300 mg) (~1000 μCi; administered as a liquid) in healthy male participants 2). A total 18 subjects were enrolled ( n = 8 part 1; 10 The low (<5%). In...
Objective To investigate the predictive value of prognostic nutritional index (PNI) for effectiveness infliximab (IFX) in patients with Crohn's disease (CD).Methods All data were retrospectively collected from Xiangya Hospital, Central South University between January 2016 and September 2021. Clinical remission at 52 weeks is primary endpoint.Results Altogether, 193 CD enrolled. PNI can identify clinical (p = 0.004), optimal cut-off was 39.2. 92/116 (79.3%) 44/77 (57.1%) high- low-PNI groups...