A5033392530- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Drug-Induced Hepatotoxicity and Protection
- Congenital heart defects research
- Cancer Mechanisms and Therapy
- Pluripotent Stem Cells Research
- Cancer, Stress, Anesthesia, and Immune Response
- Hepatocellular Carcinoma Treatment and Prognosis
- Kruppel-like factors research
- Foreign Body Medical Cases
- Malaria Research and Control
- Circadian rhythm and melatonin
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Phytochemical and Pharmacological Studies
- Chemotherapy-induced organ toxicity mitigation
- Electrospun Nanofibers in Biomedical Applications
- Synthesis and bioactivity of alkaloids
- Phagocytosis and Immune Regulation
- Ocular Diseases and Behçet’s Syndrome
- Corneal Surgery and Treatments
- Peptidase Inhibition and Analysis
- Sleep and Wakefulness Research
- Hemoglobinopathies and Related Disorders
Harbin Medical University
2013-2025
Shanghai Jiao Tong University
2020-2024
Shanghai First People's Hospital
2024
Second Affiliated Hospital of Harbin Medical University
2015-2023
Second Affiliated Hospital of Nanjing Medical University
2019-2021
Tongji University
2013-2020
Shanghai Pulmonary Hospital
2020
XinHua Hospital
2020
Nanjing Medical University
2019
Shanghai Tenth People's Hospital
2013-2015
Introduction: Since intrinsic ocular barrier limits the intraocular penetration of therapeutic protein through eye drops, repeated intravitreal injections anti-vascular endothelial growth factor (anti-VEGF) agents are standard therapy for neovascular age-related macular degeneration (nAMD), which highly invasive and may cause particular complications, leading to poor patient compliance. Methods: Using Penetratin (Pen) as enhancer hyaluronic acid (HA) retina-targeting ligand, a dual-modified...
ABSTRACT Objective This study aimed to investigate the impact of ischemic stroke (IS) on sleep homeostasis and circadian rhythms in rats, as well underlying mechanisms. Methods The middle cerebral artery occlusion model was employed induce IS rats. Sixty young sixty aged rats were randomly divided into six groups for experiments. Neurological function assessed using Garcia score, infarct size evaluated through 2,3,5‐triphenyltetrazolium chloride staining. Sleep–wake cycles monitored by...
Extrahepatic cholangiocarcinoma (EHCC) is a refractory malignancy with poor prognosis due to its early invasion, metastasis and recurrence after operation. Therefore, understanding the mechanisms of invasion key development new effective therapeutic strategies for EHCC. In present study we demonstrated that miR-221 promoted EHCC through targeting PTEN formed positive feedback loop β-catenin/c-Jun signaling pathway. We found was upregulated in specimens CC cell lines. Moreover, strongly...
Human adipose tissue-derived stem cells (ADSCs) are an attractive multipotent cell source with therapeutic applicability across diverse fields for the repair and regeneration of acute chronically damaged tissues. In recent years, there has been increasing interest in ADSC tissue engineering applications. However, mechanisms underlying regulation proliferation not fully understood. Here we show that 47 transcripts up-regulated while 23 down-regulated compared to terminally differentiated...
Zinc transporter 8 (ZnT8) was downregulated in hypoxic retina, which could be rescued by hypoxia-inducible factor-1α (HIF-1α) inhibition. Erythropoietin (EPO) protects retinal cells diabetic rats through inhibiting HIF-1α as one of its mechanisms. We hence tried to explore the effect EPO regulating ZnT8 and protecting possible mechanisms.Diabetes induced Sprague-Dawley rats. Intravitreal injection performed 1 month after diabetes onset. The CoCl2-treated rat Müller cell line (rMC-1)...
The study aimed to investigate the clinical value and prognostic patterns of neutrophil-to-lymphocyte ratio (NLR) imaging tumor capsule (ITC) in solitary hepatocellular carcinoma (HCC) patients undergoing narrow-margin hepatectomy. Data for HCC treated with surgery were extracted from Shanghai General Hospital. Clinical features recurrence-free survival (RFS), overall (OS), early recurrence investigated by Cox/logistic regression. significant variables subsequently incorporated into nomogram...
Abstract Background The protein Kruppel-like factor 13 (KLF13) is a member of the KLF family and has been identified as cardiac transcription that involved in heart development. However, relationship between KLF13 variants CHDs humans remains largely unknown. present study aimed to screen CHD patients genetically analyze functions these variants. Methods were sequenced cohort 309 population-matched healthy controls ( n = 200) using targeted sequencing. To investigate effect on functional...
Numerous microRNAs (miRNAs) have been demonstrated to be downregulated or upregulated in hepatocellular carcinoma (HCC) and play important roles its occurrence development. Therefore, the investigation of miRNAs their functions implicated genesis development HCC may provide key clues for identification effective therapeutic approaches patients with this disease. The aims present study were detect miRNA‑466 (miR‑466) expression tissues cell lines determine effects on proliferation, apoptosis...
Transcriptional regulation participates in heart development. However, the transcriptomes of human embryonic hearts during Carnegie stage (CS)10-CS16 have not been elucidated. Here, we found marked changes morphology and transcriptome from CS10 to CS11. At CS12-CS14, undergoes hypoxia-to-aerobic transformation. CS14-CS16, functions were related energy metabolism, cholesterol, processes inorganic substances. Moreover, cardiac progenitor cells derived stem (hESCs) most overlapped with those at...
Study background: Primary liver cancer is a severe health issue that imposes significant burden on families. Oxidation and subsequent cell death impair function provoke an immune response. The present article investigates the effect of Dexmedetomidine oxidation, death, expression peripheral cells, function. clinical data will represent facts evidence effects this intervention. Methods: We analyzed reporting various accounts among patients who underwent hepatectomy. surgical procedure...
Objective:The purpose of this study was to evaluate the mutation frequency SLC26A4 gene in patients with enlarged vestibular aqueduct syndrome（EVAS） and/or Mondini dysplasia（MD）, so as provide evidence for molecular diagnosis deafness. Methods:In total, 74 sensorineural hearing loss were included study. All underwent thin-layer CT examination temporal bone. The coding exons analyzed by second-generation sequencing all subjects. Results:Among them, 37 EVAS and MD（E+M group）, 28 without MD（E 9...
Artemisinin is a key anti-malarial drug and few clinically meaningful resistant cases about its application have so far been reported. The World Health Organization (WHO) officially recommended the use of ACT (Artemisinin-based Combination Therapy) as first line antimalarial to increase inhibitory efficacy prevent likely resistance development. Based on our current understanding artemisinin, set compounds were selected study their interaction with artemisinin by using yeast (S. cerevisiae)...