A5110791906- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Hearing, Cochlea, Tinnitus, Genetics
- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Urinary Bladder and Prostate Research
- Medical Research and Treatments
- Axon Guidance and Neuronal Signaling
- Apelin-related biomedical research
- Nutrition and Health in Aging
- Maternal and Perinatal Health Interventions
- Body Composition Measurement Techniques
- Dam Engineering and Safety
- Inflammatory Biomarkers in Disease Prognosis
- Menstrual Health and Disorders
- RNA modifications and cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Erythrocyte Function and Pathophysiology
- Frailty in Older Adults
- Regulation of Appetite and Obesity
- S100 Proteins and Annexins
- Musicians’ Health and Performance
- Heart Failure Treatment and Management
- Quinazolinone synthesis and applications
First Affiliated Hospital of Zhengzhou University
2019-2025
China Jiliang University
2024
Central South University
2023-2024
Guangzhou University of Chinese Medicine
2023-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Anhui Medical University
2024
Jiangxi Provincial People's Hospital
2022-2024
Nanjing University
2001-2024
Nanjing General Hospital of Nanjing Military Command
2024
First Affiliated Hospital of Jiangxi Medical College
2022-2024
Abstract Human pluripotent stem cells (hPSCs) play important role in studying the function of human glutamatergic neurons and related disease pathogenesis. However, current hPSC-derived cortical system produced a significant number inhibitory GABAergic that reduced purity excitatory neurons. In this study, we established robust neurogenesis by applying SHH inhibitor cyclopamine. Cyclopamine specified dorsal fate dose-dependent manner enhanced generation neurons, expressing PAX6, TBR1, TBR2,...
Abstract Human pluripotent stem cells (hPSCs) have potential to differentiate unlimited number of neural cells, which provide powerful tools for regeneration. To date, most reported protocols were established with an animal feeder system. However, derived on this system are inappropriate the translation clinical applications because introduction xenogenetic factors. In study, we provided optimized paradigm generate region-specific forebrain neurons from hPSCs under a defined We assessed five...
Pancreatic β-cell dysfunction resulting from inflammation has been recognized to contribute type 2 diabetes mellitus (T2DM). Netrin-1 is a new indicator of subclinical and it role in apoptosis. This study evaluated the level netrin-1 newly diagnosed T2DM patients explored whether reliable marker or key factor development T2DM.Netrin-1 was determined using commercially available human enzyme-linked immune sorbent assay (ELISA) kit. The homeostasis model assessment insulin resistance (HOMA-IR)...
// Peng Zhao 1, * , Qi Li 2, 4, Zhumei Shi 1 Charlie 5 Lin Wang 2 Xue Liu Chengfei Jiang 6 Xu Qian Yongping You Ning Ling-Zhi 7 Lianshu Ding 3 Bing-Hua Department of Neurosurgery, The First Affiliated Hospital Nanjing Medical University, 210029, China State Key Lab Reproductive Medicine, Pathology, and Collaborative Innovation Center for Cancer Personalized Center, Huai’an People’s Hospital, 223300, 4 Drum Tower Nanjing, University School, 210008, Environmental Toxicology,...
Excessive generation of reactive oxygen species (ROS) in cancer cells is associated with development, but the underlying mechanisms and therapeutic significance remain elusive. In this study, we reported that levels ROS p22phox expression are greatly increased human prostate tissues, knockdown by specific small interfering RNA (siRNA) decreased cells. We also showed stable downregulation inhibited cell proliferation colony formation, which was mediated AKT extracellular signal-regulated...
Background The efficacy of single‐allergen‐specific immunotherapy in polysensitized subjects is a matter debate. This study aimed to investigate the house dust mite (HDM) sublingual (SLIT) monosensitized and children. Methods A total 112 children, aged 4 13 years old, with HDM‐induced respiratory allergic diseases were allocated group (n = 56) or 56). Both groups treated by standard pharmacotherapy SLIT Dermatophagoides farinae (American HDM) extracts for 52 weeks. Symptoms, medications,...
Intrahepatic cholangiocarcinoma (iCCA) is a lethal hepatobiliary malignancy that arises from the epithelial cells of intrahepatic bile ducts, accounting for approximately 10% (CCA). According to 2019 World Health Organization (WHO) classification tumors digestive system, iCCA divided into small-duct type (SD-type) and large-duct (LD-type). However, it remains unknown which molecular events contribute disparity. To explore proteomic characteristics iCCA, we used an isobaric tag relative...
Background Obstructive sleep apnea (OSA) has been reported to affect cardiometabolic diseases. However, whether such association is causal still unknown. Here, we attempt explore the effect of OSA on type 2 diabetes (T2D), nonalcoholic fatty liver disease (NAFLD) and coronary heart (CHD). Methods Genetic variants associated with were requested from a published genome-wide study (GWAS) those qualified ones selected as instrumental variables (IV). Then, IV-outcome associations acquired T2D,...
Study objectives: To investigate whether electroencephalographic (EEG) activities during non-rapid eye movement sleep stage 3 (N3) in obstructive apnea syndrome (OSAS) patients were changed with continuous positive airway pressure (CPAP) treatment.Methods: A cross-sectional study of EEG activity N3 was conducted 15 moderate to severe OSAS without and CPAP treatment compared normal controls. The amplitude, absolute relative power delta, theta, alpha beta waves as well the ratio slow fast...
Purpose: To investigate intraindividual cardiac structural and functional changes before after COVID-19 infection in a previously healthy population with 3T magnetic resonance (CMR). Materials Methods: A total of 39 unhospitalized patients were recruited. They participated our previous study as non-COVID-19 volunteers undergoing baseline CMR examination recruited to perform repeated confirmed December 2022. The parameters measured compared between paired t tests. laboratory measures...
This study aims to fill the gap in understanding frequency of changing sanitary pads and key factors associated with this practice among women China. Using a convenient sampling approach, cross-sectional was conducted quota method survey from 28 cities China between October 21 31, 2020. Basic demographic characteristics, personal hygiene habits, self-efficacy, health-related quality life, disease status were collected. Multiple logistic regression model used analyze pads. A total 1682...
We explored the relationship between enuresis and obstructive sleep apnea-hypopnea syndrome (OSAHS) in children influencing factors of with OSAHS.We recruited 196 ≥5 years old from otolaryngology outpatient department, who experienced snoring underwent nasopharynx lateral radiography in-laboratory polysomnography. analyzed correlations index (AHI) lowest oxygen saturation (L-SaO2) age, body mass (BMI), tonsil size, adenoidal-nasopharyngeal (A/N) ratio using Pearson correlation test....
To investigate whether continuous positive airway pressure (CPAP) treatment would change EEG activities associated with cyclic alternating pattern (CAP subtype A1, A2, and A3) non-CAP (NCAP) during non-rapid eye movement sleep stage 3 (N3) in patients obstructive apnea (OSA).The effects of CPAP on the percentages N3 occupied by CAP NCAP, power waves NCAP were examined 18 moderate-to-severe OSA undergoing polysomnographic recordings.Apnea hypopnea index was positively correlated ratios phases...
This study examined the role of pretreatment albumin-to-fibrinogen ratio (AFR) in prognosis small-cell lung cancer (SCLC) patients receiving first-line platinum-based chemotherapy. A total 131 SCLC were enrolled. The predictive value AFR for progression free survival (PFS) and overall (OS) evaluated by receiver operating characteristic (ROC) curve analysis. factor was assessed univariate multivariate Cox proportional regression correlation between OS, PFS determined log-rank test using...
Atrial natriuretic peptide (ANP) is a cardiovascular and metabolic hormone that has been identified recently as being associated with chronic kidney disease (CKD) without diabetes. Cytokines such interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) adiponectin (ADP) contribute to the development of type 2 diabetes (T2DM). The aim here was investigate relationships ANP cytokine levels clinical variables in T2DM nephropathy patients.A total 81 participants were recruited, including 37...
In this work, the dissociation of grain boundary dislocations (GBDs) is reported in SrBi2Ta2O9 (SBT) ferroelectric thin films with c-axis orientation grown by pulsed-laser deposition on Pt/TiO2/SiO2/Si(100) substrates. Small-angle (8.2°) [001] tilt boundaries a plane close to (110) exhibit partial GBDs separated stacking faults. The dissociated grain-boundary structures have twice number and interdislocation core channel width smaller than that Frank’s geometrical rule predicts. At...
Netrin-1, a survival factor, is highly induced and excreted after renal injury in animal experiments. We aimed to research the relationship between serum netrin-1 parameters of tubule function as well circulating inflammatory cytokines evaluate effect factors for humans with type 2 diabetes mellitus (T2DM) undergoing different levels albuminuria. In total, 81 T2DM patients were included divided into three groups according their amount 24-h urine albumin excretion (UAE) receiving consent....