A5100361319- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Peptidase Inhibition and Analysis
- Colorectal and Anal Carcinomas
- Cancer therapeutics and mechanisms
- Pulmonary Hypertension Research and Treatments
- Cancer Cells and Metastasis
- Inflammatory Biomarkers in Disease Prognosis
- Colorectal Cancer Treatments and Studies
- Bone and Dental Protein Studies
- Pancreatic and Hepatic Oncology Research
- Medical Imaging and Pathology Studies
- Cancer Research and Treatments
- Macrophage Migration Inhibitory Factor
- Cardiac and Coronary Surgery Techniques
- MicroRNA in disease regulation
- Aortic Disease and Treatment Approaches
- Microbial Inactivation Methods
- Cardiovascular Conditions and Treatments
- Chronic Kidney Disease and Diabetes
- Neutropenia and Cancer Infections
- Neonatal Respiratory Health Research
Nanjing Brain Hospital
2020-2024
Nanjing Medical University
2011-2023
Nanjing Maternity and Child Health Care Hospital
2023
Academy of Medical Sciences
2023
Shandong Tumor Hospital
2021-2023
Shandong First Medical University
2021-2023
Fujian Provincial Cancer Hospital
2021-2023
Bristol-Myers Squibb (United States)
2019-2023
State Key Laboratory of Biotherapy
2021
Sichuan University
2021
Anlotinib is a novel multi-target tyrosine kinase inhibitor that designed to primarily inhibit VEGFR2/3, FGFR1-4, PDGFR α/β, c-Kit, and Ret. We aimed evaluate the safety, pharmacokinetics, antitumor activity of anlotinib in patients with advanced refractory solid tumors. (5–16 mg) was orally administered tumor once day on two schedules: (1) four consecutive weeks (4/0) or (2) 2-week on/1-week off (2/1). Pharmacokinetic sampling performed all patients. Twenty-one were further enrolled an...
Cetuximab, which modulates immune responses, may affect the efficacy of subsequent immunotherapy. Here, we assessed outcomes with nivolumab, by prior cetuximab exposure, in patients recurrent or metastatic (R/M) squamous cell carcinoma head and neck (SCCHN) who had experienced progression within 6 months platinum-containing chemotherapy.In randomized, open-label, phase III CheckMate 141 trial, were randomized 2:1 to nivolumab 3 mg/kg every 2 weeks investigator's choice (IC) single-agent...
Abstract Introduction Chromosomal aberrations are the most important etiological factors for birth defects. Optical genome mapping is a novel cytogenetic tool detecting broad range of chromosomal in single assay, but relevant clinical feasibility studies optical prenatal diagnosis limited. Material and methods We retrospectively performed analysis amniotic fluid samples from 34 fetuses with various indications detected through standard‐of‐care technologies, including karyotyping,...
Abstract Background The aim of this study was to explore the diagnostic and prognostic value serum tumor M2‐pyruvate kinase (TuM2‐PK), neuron‐specific enolase (NSE), progastrin‐releasing peptide (ProGRP) levels in patients with small cell lung cancer (SCLC). Methods TuM2‐PK, NSE, ProGRP 102 SCLC, 60 benign disease (BLD), 90 healthy controls were detected. Results SCLC group higher than those BLD ( p < 0.05) control 0.05). sensitivity detection 82.35%, 60.78%, 77.45% respectively,...
Abstract Background Osteopontin (OPN) is closely related to tumor occurrence and metastasis. This study explored the clinical value of serum OPN levels in small cell lung cancer (SCLC) patients. Methods The ELISA method was used determine level 96 SCLC patients before after first-line chemotherapy, compared with 60 healthy controls. Results treatment significantly higher than that control ( P < 0.001). Serum were disease stage, size, lymph node metastasis = 0.012, 0.034, 0.037,...
Abstract Objective To evaluate the diagnostic value of tumor M2-pyruvate kinase (TuM2-PK) and carcinoembryonic antigen (CEA) levels in both pleural effusion serum differential diagnosis benign malignant effusion. Methods This prospective study was conducted among 80 patients with (BPE group) 125 associated lung cancer (MPE group). The TuM2-PK CEA were measured by using sandwich enzyme-linked immunosorbent assay electrochemiluminescence. receiver-operating characteristic curve (ROC) analysis...
This study examined the role of pretreatment albumin-to-fibrinogen ratio (AFR) in prognosis small-cell lung cancer (SCLC) patients receiving first-line platinum-based chemotherapy. A total 131 SCLC were enrolled. The predictive value AFR for progression free survival (PFS) and overall (OS) evaluated by receiver operating characteristic (ROC) curve analysis. factor was assessed univariate multivariate Cox proportional regression correlation between OS, PFS determined log-rank test using...
Microwave ablation (MWA), a thermal ablation, is an effective treatment for breast cancer. However, residual cancer still detected. The biological characteristics of after remain unknown. To mimic insufficient MWA in vitro, cells were treated at 37°C, 42°C, 45°C, 47°C and 50°C 10 mins, the 37°C as control group. Insufficient induced EMT-like changes by down-regulation E-cadherin up-regulation vimentin N-cadherin vitro vivo. For first time, we reported promoted distant metastasis Reduced...
We studied the impact of diabetes mellitus (DM) on radial artery (RA) in 30 patients with DM and non-diabetic undergoing coronary bypass grafting autologous RA. RAs were recorded as normal if there was no cellular or stromal tissue between endothelium internal elastic lamina. The RA 26.7% diabetic 76.7% (p = 0.000298). Intimal thickness index intima:media ratio higher former than latter < 0.05; p 0.05), significant difference luminal narrowing > 0.05). Electron microscopy scores lower group...
Abstract The aim of this study was to investigate the value serum macrophage inhibitory factor‐1 (MIC‐1) level in patients with non–small cell lung cancer (NSCLC). Serum samples from 296 NSCLC and 240 healthy controls were collected. levels MIC‐1 determined by ELISA. higher than that ( P <.001). Univariate multivariate Cox regression analysis showed an independent prognostic indicator OS PFS. is a valuable biomarker for diagnosis prognosis NSCLC.
Background and Objective Keratinocyte growth factor ( KGF ) its receptor KGFR are involved in hyperplastic diseases. This study explored the effect of intercellular communication on cocultured/monocultured gingival fibroblasts keratinocytes following treatment with nifedipine. Material Methods Human were monocultured cocultured, respectively. MTT was used to investigate effects nifedipine proliferation keratinocytes. Monoculture coculture systems treated different concentrations (0, 0.2 or...
There is no standard treatment strategy for the third-line and above of advanced nonsmall cell lung cancer (NSCLC). This study aimed to investigate effects anlotinib in patients with NSCLC. Data was collected from a group who received as or post-third-line between 2017 2019. The Kaplan-Meier method used calculate progression-free survival (PFS) these treated anlotinib. Univariate analysis performed using log-rank test. Forest plot subgroup analysis.Our included 44 patients. Oral treat 26...
Background: Small cell lung cancer (SCLC) is a type of highly malignant tumor. It easy to relapse and high resistant second-line chemotherapy. There not standard plan for third-line subsequent-line treatment, hence the current study aimed explore performance nanoparticle albumin bound paclitaxel (Nab-P) in treatment recurrent SCLC. Methods: A retrospective analysis pathologically confirmed SCLC patients was conducted observe efficacy adverse reactions Nab-P treatment. Results: Among 37...
Summary Background. Anlotinib hydrochloride is an oral small molecule inhibitor of multiple tyrosine kinases, and it has been approved as a third-line therapy for patients with advanced non-small-cell lung cancer (NSCLC) in China. This dose-exploration study was designed to investigate the feasibility anlotinib combination other chemotherapy regimens nonsquamous NSCLC. Methods. phase I followed 3 + dose reduction design three doses (12 mg, 10 8 mg). given at initial 12 mg pemetrexed (500...
e13586 Background: To establish the safety, pharmacokinetics, recommended dose, and antitumor activity of anlotinib, a novel oral multi-target tyrosine kinase inhibitor, in patients with advanced refractory solid tumors. Methods: Anlotinib was given orally once day for consecutive 4 weeks or 2 on/1 week off. In dose group, 5mg/d (n = 4) 10mg/d explored; off 3), 16mg/d 12mg/d 21) explored. Human plasma urine samples were analyzed by liquid chromatography-mass spectrometry. Results:...
We aimed to describe the anatomic distribution of periarterial pulmonary sympathetic nerves and observe long-term morphometric functional changes after artery denervation (PADN), a novel therapy for arterial hypertension (PAH).A total 45 beagles were divided into innervation group (n = 3, 33.3% females), PAH 35, 34.3% females) control 7, 28.5% females). The was randomly no-PADN 7), instant-PADN 1M-PADN 2M-PADN 7) 3M-PADN subgroups. sacrificed reveal arteries. induced by injecting...
cytokeratin-19 fragment (CYFRA21-1) is a soluble protein in serum, and may be useful circulating tumor marker. The aim of this study to investigate the diagnostic value peripheral blood CYFRA21-1 non-small cell lung cancer (NSCLC).the levels were detected 107 patients with NSCLC 51 benign pulmonary diseases by enzyme linked immunosorbent assay, ROC curve was used analyse results.singificant difference between group disease (Chi-Square=47.343, P < 0.001). At threshold 3.3 ng/mL, sensitivity...