A5100751869- Glioma Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Medical Research and Treatments
- Photodynamic Therapy Research Studies
- RNA Research and Splicing
- Cancer-related gene regulation
- Anesthesia and Neurotoxicity Research
- MicroRNA in disease regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Research and Treatments
- Circular RNAs in diseases
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Meningioma and schwannoma management
- Tryptophan and brain disorders
- Pain Mechanisms and Treatments
- Toxin Mechanisms and Immunotoxins
- Neuroendocrine regulation and behavior
- Axon Guidance and Neuronal Signaling
- Phosphodiesterase function and regulation
- Cancer-related molecular mechanisms research
- Antibiotics Pharmacokinetics and Efficacy
- Neurosurgical Procedures and Complications
- Healthcare Decision-Making and Restraints
Nanjing Medical University
2015-2025
Xiangya Hospital Central South University
2024
Central South University
2024
Second People’s Hospital of Huai’an
2013-2023
Huaian First People’s Hospital
2010-2023
Xuzhou Medical College
2013-2023
Jiangsu Province Hospital
2010
Southern Medical University
2006
Zhujiang Hospital
2004-2006
Recent studies have demonstrated neuroinflammation and increased cytokine levels are associated with depression. Aware of the efficacy potential anti-inflammatory antioxidative activity proanthocyanidin, present study was designed to investigate effects proanthocyanidin on lipopolysaccharide (LPS)-induced depressive-like behavior in mice. In depressive tests, immobility time forced swimming test (FST) tail suspension (TST) when mice were administrated a single dose LPS (0.83mg/kg, i.p.),...
Background/Aims: To determine the cellular functions and clinical significance of micro-758-5p (miR-758-5p) in glioblastoma (GBM) by targeting zinc finger BTB domain-containing protein 20 (ZBTB20). Methods: Fifty-five paired GBM tissues adjacent normal tissues, cell lines (U118, LN-299, H4, A172, U87-MG, U251), human astrocyte line (HEB) were used. miR-758-5p mimics, ZBTB20 siRNA, pcDNA3.1-ZBTB20 transiently transduced into cancer cells independently or together. qRT-PCR was conducted to...
Traumatic brain injury (TBI) disrupts oxygen homeostasis in the brain, leading to excessive reactive species (ROS) production and dysregulated antioxidant mechanisms, which fail clear excess ROS. This ROS overload promotes expression of pro-inflammatory genes, releasing cytokines chemokines creating a vicious "ROS-neuroinflammation" cycle, making it essential break this cycle for effective TBI treatment. In study, we developed cysteine-alanine-glutamine-lysine (CAQK) peptide-modified...
BACKGROUND:Circular RNAs (circRNAs) are widely expressed in mammals and can regulate the development progression of human tumors. has_circ_0015758 (circ-CFH) is an exon circRNA transcript from GRCh37/hg19 fragment chromosome 1 homologous to protein-coding gene complement factor H (CFH). Currently, function circ-CFH glioma remains unclear. MATERIAL AND METHODS:In our study, circ-CFH, miR-149, Akt1 mRNA expression levels were analyzed by qRT-PCR assays. To investigate cell proliferation,...
// Peng Zhao 1, * , Qi Li 2, 4, Zhumei Shi 1 Charlie 5 Lin Wang 2 Xue Liu Chengfei Jiang 6 Xu Qian Yongping You Ning Ling-Zhi 7 Lianshu Ding 3 Bing-Hua Department of Neurosurgery, The First Affiliated Hospital Nanjing Medical University, 210029, China State Key Lab Reproductive Medicine, Pathology, and Collaborative Innovation Center for Cancer Personalized Center, Huai’an People’s Hospital, 223300, 4 Drum Tower Nanjing, University School, 210008, Environmental Toxicology,...
BACKGROUND:We desired to observe the changes of transforming growth factor-β1/drosophila mothers against decapentaplegic protein (TGF-β1/Smad3) signaling pathway in hippocampus region cerebral ischemic stroke rats so that effects this on nerve cells can be investigated. MATERIAL AND METHODS:The models were built by middle artery occlusion (MCAO) vivo and oxygen-glucose deprivation (OGD) vitro. TGF-β1 inhibitors injected into rat while TGF-β1, siRNA, Smad3, Smad3 siRNA transfected cells....
To investigate the mediating effect of resilience on perceived social support and fear cancer recurrence (FCR) in glioma patients.
Nanomedicine uses nanotechnology-based strategies for precision tumor therapy, including passive and ligand-mediated active targeting by nanocarriers. However, the possible biotoxicity of chemosynthetic nanovectors limits their clinical applications. A novel natural egg yolk lipid nanovector (EYLN) was developed effective loading delivery therapeutic agents. Lipids were extracted from yolks reassembled into nanosized particles. EYLNs' stability, cellular uptake, toxicity, capacity agents...
Primary Objective: We aim to study the effects of chronic aminoguanidine (AG) administration on learning and memory impairment after TBI explore potential mechanism involved in this process.Research Design: Male C57BL/6J mice were divided into 6 groups: Control, + Veh, TBI+ AG (50, 100, 200 400 mg/kg, i.p.).Methods Procedures: Then, we measured cyclicadenosine 3ʹ, 5ʹ-monophosphate (cAMP) content, phosphorylated form cAMP-response element binding protein (p-CREB) level, iNOS, brain-derived...
Attention dysfunction has been observed among many kinds of nervous system diseases, including glioma. This study aimed to investigate the correlation between glioma localization, malignancy, postoperative recovery time and attention deficit.A total 45 patients with who underwent surgical resection 18 healthy volunteers were enrolled. The network test, digital span color trail test II Stroop used detect characteristics deficit.Orientation was detected in parietal lobe tumor group, execution...
AIMS: To evaluate the prognostic and clinicopathological features of glioma with BRMS1L expression. METHODS: Total 120 samples were obtained as discovery cohort. CGGA, GSE TCGA datasets validation sets. Furthermore, Kaplan-Meier survival multivariate Cox analysis wer e used to distributions. Moreover, functional role was also analyzed by transwell assay. RESULTS: In cohort, decreased expression significantly associated high-grade well higher mortality in (log-rank test, p< 0.01). And three...
Glioma is the most common malignant brain tumor in adults and represents one of aggressive life‑threatening types cancer humans. Increasing studies have revealed that microRNAs are abnormally expressed various human cancer, oncogenic or suppressive roles, which depend primarily on type cancer. The present study aimed to investigate expression level effects microRNA‑186 (miR‑186) glioma, its underlying molecular mechanism. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR)...
Abstract Objective Microvascular decompression (MVD) has become an accepted treatment modality for the vertebral artery (VA)–involved hemifacial spasm (HFS). The aim of this retrospective study was to evaluate clinical and surgical outcomes HFS patients undergoing MVD cranial nerve complications investigate reasonable transposition procedures two different anatomic variations VA. Methods Between January December 2018, 109 underwent first involving VA at Nanjing Drum Tower Hospital. Based on...