A5101661455- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Bone Metabolism and Diseases
- Food Quality and Safety Studies
- Microbial Metabolic Engineering and Bioproduction
- Chemokine receptors and signaling
- Fatty Acid Research and Health
- Traditional Chinese Medicine Studies
- Medical Research and Treatments
- Diabetes Management and Research
- Pediatric health and respiratory diseases
- Wound Healing and Treatments
- Fermentation and Sensory Analysis
- Hip and Femur Fractures
- Orthopaedic implants and arthroplasty
- Fungal Biology and Applications
- Pharmacological Effects of Natural Compounds
- Sirtuins and Resveratrol in Medicine
- Enzyme Catalysis and Immobilization
- Orthopedic Infections and Treatments
- Biofuel production and bioconversion
- Diabetic Foot Ulcer Assessment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
Zhejiang Pharmaceutical College
2016-2024
Huazhong University of Science and Technology
2011-2024
Tongji Hospital
2011-2024
Nanchang University
2024
State Key Laboratory of Food Science and Technology
2024
National Clinical Research Center for Digestive Diseases
2024
China Telecom (China)
2021
China Telecom
2021
Dalian Medical University
2019
Second Affiliated Hospital of Dalian Medical University
2019
Abstract Signals targeting OCs to bone and resorption sites are not well characterized. A chemoattractant receptor (CXCR4), highly expressed in murine OC precursors, mediated their chemokine (SDF-1)-induced chemoattraction, collagen transmigration, MMP-9 expression. Thus, vascular stromal SDF-1 may direct precursors into marrow for development resorption. Introduction: Although chemokines essential trafficking homing of circulating hematopoietic cells under normal pathological conditions,...
Chemoattractants that recruit OC precursors to locally inflamed sites of resorption are not well known. A chemokine receptor, CCR1, was expressed in and elevated mature OCs, its ligands promoted precursor recruitment, RANKL development, motility. Cytokines induced OB release such chemokines, which may therefore significantly contribute inflammatory bone loss.Chemokines, primarily two major (CXC, CC) families, essential signals for the trafficking localization circulating hematopoietic cells...
Nitric oxide (NO) is a multifunctional signaling molecule and key vasculoprotective potential osteoprotective factor. NO regulates normal bone remodeling pathological loss in part through affecting the recruitment, formation, activity of bone-resorbing osteoclasts. Using murine RAW 264.7 primary marrow cells or osteoclasts formed from them by receptor activator NF-kappaB ligand (RANKL) differentiation, we found that inducible nitric-oxide synthase (iNOS) expression generation were stimulated...
Osteoclasts (OCs) are the cells uniquely responsible for dissolving both organic and inorganic components of bone during development remodeling throughout life. These originate from hematopoietic precursors monocyte/macrophage lineage that present in marrow peripheral circulation, their numbers and/or activity frequently increased a wide array clinical disorders associated with excessive loss affect millions people (). For many years, investigations into how OCs develop function have been...
Neuropathic pain can be considered as a form of chronic stress that may share common neuropathological mechanism between and stress-related depression respond to similar treatment. Ferulic acid (FA) is major active component angelica sinensis has been reported exert antidepressant-like effects; however, it remains unknown whether FA ameliorate constriction injury (CCI)-induced neuropathic the involvement descending monoaminergic system opioid receptors. Chronic treatment with (20, 40 80...
This study aims to explore the role of indoleamine-2,3-dioxygenase (IDO)/kynurenine (KYN) pathway tryptophan (TRY) metabolism in behavioral alterations observed hepatic encephalopathy (HE) rats. Expression levels proinflammatory cytokines were tested by QT-PCR and ELISA, IDOs Western blot, 5-hydroxytryptamine (5-HT), KYN, TRY, 3-hydroxykynurenine (3-HK), kynurenic acid (KA) different brain regions estimated using HPLC. Effects IDO direct inhibitor 1-methyl-l-tryptophan (1-MT) on cognitive,...
Objective: Our study was designed to investigate whether indoleamine-2,3-dioxygenase (IDO)-mediated kynurenine/tryptophan (KYN/TRP) pathway participates in the development of emotional deficits ethanol addiction/withdrawal mice. Methods: Expression proinflammatory factors including tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) were tested by enzyme linked immunosorbent assay (ELISA). The IDO levels hippocampus, cerebral cortex amygdala measured polymerase...
The aim of the present research was to investigate effects irisin, a skeletal muscle-derived myokine, on spinal cord injury (SCI) in rats and explore possible mechanisms. SCI model constructed male SD rats. irisin were assessed via behavior tests including Basso, Beattie, Bresnahan (BBB) scoring method inclined plane test, followed by histomorphology HE staining, Nissl transmission electron microscope examination. Biochemical analyses PCR, Western blots ELISA employed further evaluate...
Background: Diabetic lower extremity ulcer, including diabetic foot ulcer (DFU) and leg is one of the refractory complications diabetes, treatment which challenging, expensive, lengthy. Recombinant Human Granulocyte/Macrophage Colony-stimulating Factor (rhGM-CSF) an immunomodulatory cytokine that has been mainly applied in hematological diseases. Clinical evidence regarding GM-CSF ulcers limited. This study first case series investigates repurpose effects rhGM-CSF on healing real clinical...
Although chemokines play essential roles in the trafficking and homing of many circulating hematopoietic cell types, their potential influences on osteoclast (OC) recruitment or bone remodeling are not well known. Therefore, chemokine receptor expression was analyzed by RNase protection assay during OC formation induced RANKL a murine mononuclear line (RAW 264.7). Relatively high CXCR4 detected RAW cells (pre-OCs), whereas levels were downregulated RAW-OC development. SDF-1, unique ligand...
The antidepressant-like effect of trans-astaxanthin, a compound present rich in algae, was evaluated through behavioral and neurochemical methods. Results showed that trans-astaxanthin treatment significantly decreased the immobility time force swim test tail suspension test, but did not influence locomotor activity. Trans-astaxanthin effectively antagonize hypothermia ptosis induced by reserpine. However, pre-treatment with para-chlorophenylalanine abolished anti-immobility test. These...
Abstract Understanding sex disparities in modifiable risk factors across the lifespan is essential for crafting individualized intervention strategies. We aim to investigate age-related disparity cardiometabolic phenotypes a large nationwide Chinese cohort. A total of 254,670 adults aged 40 years or older were selected from population-based cohort China. Substantial prevalence metabolic diseases observed different age strata, particularly dyslipidemia and its components. Generalized additive...
Abstract The aim of this study was to investigate the role 17β‐estradiol (E2)‐mediated oestrogen receptor (ER) in modulating depressive‐like behaviours ovariectomy (OVX) mice and associated mechanisms. E2 administrated OVX mice. behaviour physiological changes including immobility time tail suspension test (TST) forced swimming (FST), levels serum E2, inflammatory mediators, oxidative stress factors, indoleamine2,3‐dioxygenase 1 (IDO1) neurotransmitters mediated by IDO1 activation were then...
Hyperglycemia is common and hard to control in surgical patients with diabetes. We retrospectively investigated short-term effects of continuous subcutaneous insulin infusion (CSII) perioperative diabetes.Perioperative diabetes discharged between January 1, 2006 2012 were included. Glucose postoperative outcomes compared the using CSII or non-CSII therapy.We identified 108 pairs matched by propensity category who therapy (CSII group) (control group). The group had significantly lower fasting...