A5047976948- Smart Materials for Construction
- Geotechnical Engineering and Soil Stabilization
- Wound Healing and Treatments
- Cancer-related molecular mechanisms research
- Diabetic Foot Ulcer Assessment and Management
- RNA modifications and cancer
- Immune cells in cancer
- Geotechnical Engineering and Underground Structures
- BRCA gene mutations in cancer
- Cancer-related gene regulation
- Radiomics and Machine Learning in Medical Imaging
- Climate change and permafrost
- Winter Sports Injuries and Performance
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Maternal and fetal healthcare
- Nanoparticle-Based Drug Delivery
- Grouting, Rheology, and Soil Mechanics
- Concrete and Cement Materials Research
- Maternal and Perinatal Health Interventions
- Cancer Research and Treatments
- Pregnancy and preeclampsia studies
- Innovative concrete reinforcement materials
- RNA regulation and disease
- Geotechnical Engineering and Analysis
National Clinical Research Center for Digestive Diseases
2024
Huazhong University of Science and Technology
2024
Tongji Hospital
2024
Second Affiliated Hospital of Nanjing Medical University
2019-2024
Nanjing Medical University
2018-2023
Jilin Medical University
2013-2014
Cleveland Clinic
2009
Background . Maternal health is an important part of basic public services in China’s medical reform. Effective management guarantee maternal health. Telemedicine has been widely used management. Objective This study explores the role usual healthcare combined with telemedicine high-risk pregnancy. Methods The was a retrospective. Data were obtained from Hangzhou Maternity Hospital between October 2012 and September 2016, including 93465 pregnant women who pregnancy (usual group) 134884...
Triple-negative breast cancer (TNBC) has a poorer outcome than other subtypes of cancer, and the discovery dysregulated microRNA (miRNA) their role in tumor progression provided new avenue for elucidating mechanism involved TNBC. In this study, we identified that miR-3178 was significantly reduced TNBC, low expression correlated with poor overall survival TNBC but not non-TNBC. The ectopic overexpression suppressed cell proliferation, invasion, migration by inhibiting...
A material that possesses high loading efficiency (in terms of delivering small molecular drugs, nucleic acids, peptides, and proteins) has various medical applications, such as in tumor diagnosis gene therapy or chemotherapy tumors. Mesoporous silica nanoparticles are ideal nanocarriers for constructing drug delivery systems because the unique mesoporous channels encapsulation sustainable release anticancer drugs. Herein, we demonstrate a doxorubicin (DOX)–peptides double-loaded -response...
Background: Diabetic lower extremity ulcer, including diabetic foot ulcer (DFU) and leg is one of the refractory complications diabetes, treatment which challenging, expensive, lengthy. Recombinant Human Granulocyte/Macrophage Colony-stimulating Factor (rhGM-CSF) an immunomodulatory cytokine that has been mainly applied in hematological diseases. Clinical evidence regarding GM-CSF ulcers limited. This study first case series investigates repurpose effects rhGM-CSF on healing real clinical...
Breast cancer (BC) is the most common cause of death worldwide, and its incidence increasing every year. This study aims to investigate expression characteristics ADAR gene in breast explore role occurrence development BC possible mechanism.TCGA portal was used detect including BC, correlation with clinicopathological data as well other genes analyzed via UALCAN database. The TISCH database evaluated different types cell populations at single-cell level. Kaplan-Meier plotter predict between...
Abstract Breast cancer (BC) stands as a prominent contributor to global cancer‐related mortality, with an increasing incidence annually. This study aims investigate AGRN gene expression in BC, well explore its influence on the tumor immune microenvironment. displayed pronounced upregulation BC tissues relative paracancerous tissues. Single‐cell RNA analysis highlighted AGRN‐specific elevation within cell clusters and also showed expressed stromal clusters. was positively correlated...
The five major RNA methylation modifications (m6A, m1A, m6Am, m5C, and m7G) exert biological roles in tumorigenicity immune response, mediated mainly by "writer" enzymes. Here, the prognostic values of enzymes TCP1 role drug resistance breast cancer (BC) were explored for further therapeutic strategies.We comprehensively characterized clinical, molecular, genetic features subtypes consensus clustering. modification "Writers" related genes_risk (RMW_risk) model BC was constructed via a...
IBM Watson for Oncology (WFO) is an artificial intelligence cognitive computing system that provides confidence-ranked, evidence-based treatment recommendations cancer. We examine the level of agreement breast cancer chemotherapy between WFO recommended and clinical use in a large population cases.A total 1,301 patients were reviewed The First Affiliated Hospital with Nanjing Medical University, China from June 2013 to December 2017. Patients' data entered manually into by trained senior...
In order to accurately simulate the combined action of rainfall, high temperature and sunshine effect on asphalt mixture, experiment water-temperature-radiation circulation was designed. The changes air void, split tensile strength, freeze-thaw splitting strength dynamic stability were quantitatively analyzed under condition different asphalt-aggregate ratio striking times during cycle. Grey correlation analysis method used analyze influence factors four parameters mentioned above,...
Breast cancer (BRCA) ranks first among cancers in terms of incidence and mortality rates women, primarily owing to metastasis, chemo-resistance, heterogeneity. To predict long-term prognosis design novel therapies for BRCA, more sensitive markers need be explored.Data from 1089 BRCA patients were downloaded TCGA database. Pearson's correlation analysis univariate multivariate Cox regression analyses performed assess the role cell death-related genes (CDGs) predicting prognosis. Kaplan-Meier...
e22065 Background: Mutations in BRCA1 and BRCA2 genes lead to defects DNA repair. Estrogen receptor modulates transcription of responsible for cell division, which depends on cell's ability repair genomic integrity. Differential efficacy endocrine therapy breast cancer, therefore, may be possible depending the tumor's BRCA mutation status. Methods: Through an IRB approved registry, cancer patients tested mutations treated with hormone-receptor positive non-metastatic disease were identified....
This paper improves the method of calculating vertical bearing capacity bored piles, and unifies calculation singe pile under horizontal force, as well adds modifies design parameters specification, finally utilizes actual example to make a unified test above methods. The results proved that, through optimization bridge foundation it can significantly reduce construction cost, makes length, diameter, reinforcement more safe reasonable. At same time, has great directive significance bridge.
Based on the actual design and construction experience, application of cement-soil in road bridge foundation is designed. First all, basic parameters soil are determined through coring; then, mix proportion designed; Finally, structural conducted according to different usages. The results show that using improve subgrade, it can not only effectively subgrade strength durability, but also be convenient for construction, save a lot building materials reduce project cost, which has great...
In this paper, the poor applicability problem which bridge foundation bored piles reinforcement design in actual application process is not related to specifications studied, and pile length calculation L P optimized specifically, as well as, friction problems are also researched. Verified by examples show that fully meet engineering safety requirements, meanwhile, more economical.
Through using the technology of laser ranging and establishing stations which can monitor snow depth automatically, a real-time, continuous automatic monitoring for status snow-covered roads was achieved. In this paper, forecast warning system constructed. Firstly, data transmitted to database GPRS technology. Then disaster evaluated quantitatively according existing criteria, evaluation results were stored back database. Finally, about published through publishing platform. The indicated...