A5115855481- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Machine Learning in Healthcare
- Cerebrospinal fluid and hydrocephalus
- Inflammasome and immune disorders
- Neuroscience of respiration and sleep
- Neuropeptides and Animal Physiology
- Quantum Chromodynamics and Particle Interactions
- Child Nutrition and Feeding Issues
- Hereditary Neurological Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Traumatic Brain Injury and Neurovascular Disturbances
- Particle physics theoretical and experimental studies
- Stress Responses and Cortisol
- Nerve injury and regeneration
- Black Holes and Theoretical Physics
- Alzheimer's disease research and treatments
- Sleep and Wakefulness Research
- Signaling Pathways in Disease
- Carcinogens and Genotoxicity Assessment
- Phytochemistry and Biological Activities
- Diabetes Management and Education
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Effects and risks of endocrine disrupting chemicals
Nanjing Medical University
2013-2025
Jinzhou Medical University
2025
Nanjing University of Posts and Telecommunications
2024-2025
Sichuan Academy of Traditional Chinese Medicine
1990-2025
Jiangsu Province Hospital
2019-2024
North China University of Technology
2024
Sun Yat-sen University
2024
Nankai University
2024
Peking University
2022-2024
Fudan University
2014-2024
Abstract Background Neuroinflammation and blood-brain barrier (BBB) disruption are two vital mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Recently, melanocortin-1 receptor (Mc1r) activation by Nle4-D-Phe7-α-MSH (NDP-MSH) was shown to play a neuroprotective role in an experimental autoimmune encephalomyelitis (EAE) mouse model. This study aimed investigate whether NDP-MSH could alleviate neuroinflammation BBB after ICH, as well the potential its roles....
Regular exercise has been shown to reduce the risk of Alzheimer's disease (AD). Our previous study showed that protein aquaporin 4 (AQP4), which is specifically expressed on paravascular processes astrocytes, necessary for glymphatic clearance extracellular amyloid beta (Aβ) from brain, can delay progression disease. However, it not known whether AQP4-regulated Aβ involved in beneficial effects AD patients. results after 2 months voluntary wheel exercise, APP/PS1 mice were 3 old at start...
Abstract Aims As a normal physiological process, sleep has recently been shown to facilitate clearance of macromolecular metabolic wastes from the brain via glymphatic system. The aim present study was investigate pathophysiological roles astroglial aquaporin 4 (AQP4), functional regulator clearance, in mouse model chronic disruption (SD). Methods Adult AQP4 null mice and wild‐type (WT) were given 7 days SD using improved rotating rod method, then received behavioral, neuropathological,...
Objective To evaluate the clinical value of systemic immune-inflammation index (SII) based on peripheral blood neutrophil, lymphocyte, and platelet count in evaluating subtype severity depression patients with depressive disorder. Methods This retrospective cohort study was conducted Third People’s Hospital Fuyang City from January 1, 2020 to December 31, 2022. The data included sociodemographic information at admission, data, discharge diagnosis inflammatory markers. Patients were divided...
Abstract: Recent successive approval of anti-amyloid-β (Aβ) monoclonal antibodies as disease-modifying therapies against Alzheimer's disease (AD) has raised great confidence in the development anti-AD therapies; however, current still face dilemma significant adverse reactions and limited effects. In this review, we summarized therapeutic characteristics approved anti-Aβ immunotherapies dialectically analyzed gains losses from clinical trials. The review further proposed reasonable selection...
Background Increasing evidence supports the role of microRNAs (miRNAs) in major depressive disorder (MDD), but pathophysiological mechanism remains elusive. Aims To explore microRNA-451a (miR-451a) pathology and behaviours depression. Methods Abnormal miRNAs such as miR-451a reported previously serum patients with MDD were screened then confirmed a mouse model depression induced by chronic restraint stress (CRS). Eight-week-old male C57BL/6 mice had overexpression medial prefrontal cortex...
Non-cognitive behavioral and psychological symptoms often occur in Alzheimer's disease (AD) patients mouse models, although the exact neuropathological mechanism remains elusive. Here, we report hyperactivity with significant inter-individual variability 4-month-old APP/PS1 mice. Pathological analysis revealed that intraneuronal accumulation of amyloid-β (Aβ), c-Fos expression glutamatergic neurons activation astrocytes were more evident frontal motor cortex hyperactive mice, compared to...
Abstract Motivation The capability to predict the potential drug binding affinity against a protein target has always been fundamental challenge in silico discovery. traditional experiments vitro and vivo are costly time-consuming which need search over large compound space. Recent years have witnessed significant success on deep learning-based models for drug-target prediction task. Results Following recent of Transformer model, we propose multigranularity protein–ligand interaction (MGPLI)...
Abstract Optical information encryption is an effective security strategy currently used to protect data and prevent leakage. However, the optical technology based on mechanoluminescent (ML) materials faces challenges of single mode lack systematic dual‐key decryption strategies. In this study, a three‐layer structure encoder proposed using porous ML material as luminescent layer, quartz transparent tube with pressure‐sensing capabilities stress‐loading photodetector recognition layer. A...
<title>Abstract</title> <bold>BACKGROUND:</bold> Traditional statistical methods(e.g.,logistic regression)are widely used for prognostic prediction in SAH patients but may fail to capture complex non-linear interactions,such as between circadian rhythms and physiological parameters.Machine learning algorithms,particularly SVM with SHAP interpretability,offer a robust framework handling high-dimensional data improving predictive accuracy.This study innovatively integrates rhythm-based time...
Abstract Neuregulin‐1 (NRG‐1) regulates numerous aspects of neural development and synaptic plasticity; the functions NRG‐2 NRG‐3 are presently unknown. As a first step toward understanding how NRGs contribute to distinct function, we characterized their regional subcellular expression patterns in developing brain. The NRG‐1–3 mRNAs was compared postnatally (P0, P7, adult) by using situ hybridization. NRG‐1 is highest at birth, whereas mRNA levels increase with development; both genes...
Standard-dose caffeine citrate has been routinely prescribed for apnea of prematurity (AOP) management; however, some preterm infants respond well to the therapy while others do not. The AOP phenotype attributed solely immature control respiratory system consequent birth, but there are also important genetic influences. Based on our previous report, we tested hypothesis that human circadian locomotor output cycles kaput ( CLOCK ) gene polymorphisms play a role in response infants. We studied...
The aim of the present study was to assess safety profile and outcomes a ceftazidime-avibactam (CAZ-AVI)-based regimen compare them with those tigecycline (TGC)-based in intensive care unit (ICU) for treatment carbapenem-resistant Klebsiella pneumoniae (CRKP), which is classified into hospital-acquired pneumonia (HAP) ventilator-associated (VAP).Clinical microbiological cure rates, 28-day survival evaluation findings were compared between patients treated CAZ-AVI-based TGC-based this...
Abstract The ultrafast‐laser‐matter interactions enable “top‐down” laser surface structuring, especially for materials difficult to process, with “bottom‐up” self‐organizing features. subwavelength scenarios of laser‐induced structuring are improved in defects and long‐range order by applying positive/negative feedbacks. It is still hardly reported supra‐wavelength more associated complicated thermo/hydro‐dynamics. For the first time knowledge, near‐field‐regulated ultrafast‐laser...
The involvement of matrix metalloproteinase (MMP) 9 in methamphetamine-induced neurotoxicity was evaluated. Injection mice with stimulant or toxic doses methamphetamine upregulated MMP9 gene expression the brain within 5 min. By 24 h, returned to control levels stimulant-treated mice, but remained elevated animals exposed methamphetamine. Reductions striatal dopamine levels, a marker neurotoxicity, developed 1–7 days after exposure, were not accompanied by concomitant changes expression. In...
This study aims to investigate the association between systemic immune-inflammatory index (SII) and suicide attempt (SA) in children adolescents with first-episode, drug-naïve Major Depressive Disorder (MDD) during COVID-19 pandemic.A retrospective was conducted on 263 MDD patients hospitalized at Third Hospital of Fuyang City 2020 2022. Patients were categorized into two groups based presence previous SA. The compared differences SII clinical characteristics used receiver operating...