A5101702591- Intracerebral and Subarachnoid Hemorrhage Research
- Nanoparticle-Based Drug Delivery
- Traditional Chinese Medicine Analysis
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Piperaceae Chemical and Biological Studies
- Neurological Disease Mechanisms and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Advanced Glycation End Products research
- Nitric Oxide and Endothelin Effects
- Genomics, phytochemicals, and oxidative stress
- Cardiac Fibrosis and Remodeling
- Receptor Mechanisms and Signaling
- Retinoids in leukemia and cellular processes
- Cholinesterase and Neurodegenerative Diseases
- Porphyrin and Phthalocyanine Chemistry
- Kruppel-like factors research
- Cytokine Signaling Pathways and Interactions
- Acute Myocardial Infarction Research
- Medicinal Plants and Neuroprotection
- Lipid Membrane Structure and Behavior
- Phenothiazines and Benzothiazines Synthesis and Activities
- Phytochemistry and Bioactive Compounds
- Seed and Plant Biochemistry
- Diet, Metabolism, and Disease
Dalian Medical University
2014-2024
Harbin Medical University
2020-2022
First Affiliated Hospital of Harbin Medical University
2020-2022
China South Industries Group (China)
2021
Chongqing Medical University
2019-2020
Harbin University
2020
Abstract Background Neuroinflammation and blood-brain barrier (BBB) disruption are two vital mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Recently, melanocortin-1 receptor (Mc1r) activation by Nle4-D-Phe7-α-MSH (NDP-MSH) was shown to play a neuroprotective role in an experimental autoimmune encephalomyelitis (EAE) mouse model. This study aimed investigate whether NDP-MSH could alleviate neuroinflammation BBB after ICH, as well the potential its roles....
Although piperine can inhibit cells of tumors, the poor water solubility restricted its clinical application. This paper aimed to develop mixed micelles based on Soluplus® and D-α-tocopherol polyethylene glycol succinate (TPGS) improve aqueous anti-cancer effect.Piperine-loaded were prepared using a thin-film hydration method, their physicochemical properties characterized. The cellular uptake was confirmed by confocal laser scanning microscopy in A549 lung cancer HepG2 liver cells. In...
Oxidative stress and neuronal apoptosis play crucial roles in secondary brain injury (SBI) after intracerebral hemorrhage (ICH). Recently, Nle4-D-Phe7-α-melanocyte-stimulating hormone (NDP-MSH), a synthetic agonist of the melanocortin-1 receptor (Mc1r), has been proved to inhibit neuroinflammatory several diseases. This study is aimed at exploring if NDP-MSH could reduce oxidative following ICH, as well potential mechanism. A mouse ICH model was induced by autologous blood injection....
Fenretinide (4-HPR), as a semi-synthetic retinoid, has apoptosis-promoting effects single agent and chemotherapy synergist in vitro. When human ovarian cancer cells line (A2780s) was treated with both PTX 4-HPR, there synergistic anti-cancer effect demonstrated average combination index of 0.44. In this research, new TPGS-Soluplus® mixed micelles were developed which encapsulation efficiencies paclitaxel (PTX) fenretinide (4-HPR) high 98%, the diameter 66.26 nm. Cytotoxicity co-delivered...
In this study, mixed micelles of Soluplus® and TPGS were developed for co-administering docetaxel (DTX) piperine (PIP) exerting the synergistic effect, which increased cytotoxicity improved anti-cancer activity in HepG2 cell lines compared to free DTX. These vitro (MTT assay, intracellular uptake micelles) vivo (pharmacokinetic immunostaining, TUNEL analysis) studies exhibited advantages co-delivery anticancer drugs with Soluplus®/TPGS by furthermore established that DTX PIP via could be a...
Myocardial infarction (MI) is the primary cause of cardiac mortality. Esculentoside A (EsA), a triterpenoid saponin, has anti-inflammatory and antioxidant activities. However, its effect on MI remains unknown. In this study, protective mechanisms EsA against were investigated. significantly alleviated hypoxia-induced HL-1 cell injury, including increasing viability, inhibiting reactive oxygen species (ROS) production, mitochondrial membrane potential (MMP) lactate dehydrogenase (LDH)...
Liver cancer remains a major problem around the world. Resibufogenin (RBG) is bioactive compound that was isolated from Chansu (also called toad venom or poison), which popular traditional Chinese medicine obtained skin secretions of giant toads. RBG has strong antitumor effects, but its poor aqueous solubility and cardiotoxicity have limited clinical use. The aim this study to formulate RBG-loaded poly(lactic-co-glycolic acid) (PLGA)-D-α-tocopheryl polyethylene glycol 1000 succinate...
Abstract Background Specific highly polarized aquaporin‐4 (AQP4) expression is reported to play a crucial role in blood‐brain barrier (BBB) integrity and brain water transport balance. The upregulation of polymerase δ‐interacting protein 2 (Poldip2) was involved aggravating BBB disruption following ischemic stroke. This study aimed investigate whether Poldip2‐mediated cerebral edema formation mouse bacterial meningitis (BM) model occur via induction AQP4 polarity loss. Methods Results Mouse...
Clinically, co-delivery of chemotherapeutics has been limited by poor water-solubility and severe systemic toxicity. This study was aimed at integrating the merits combination chemotherapy mixed micellar technology demonstrating anticancer potential doxorubicin (DOX) dihydroartemisinin (DHA) co-loaded Soluplus®-TPGS system. In this study, physiochemically stable multidrug loaded micelles were successfully prepared, encapsulation efficiencies DOX DHA as high 90%, average diameter 64.27 nm....
Aromatic vinegar with abundant bioactive components can be used as a food additive to assist the treatment of various diseases. However, its effect on non-alcoholic fatty liver disease (NAFLD) is still unknown. The purpose this study was investigate mechanism Hengshun aromatic in preventing NAFLD vivo and vitro . applied rats fed high-fat diet (HFD) HepG2 cells challenged palmitic acid (PA). Our results showed that markedly improved cell viabilities attenuated damage levels TC, TG, FFA, AST,...
Exploration of lead compounds against Parkinson's disease (PD), a neurodegenerative disease, is great important. Dioscin, bioactive natural product, shows various pharmacological effects. However, the activities and mechanisms dioscin PD have not been well investigated. In this study, tests on 6-hydroxydopamine (6-OHDA)-induced PC12 cells rats were carried out. The results showed that dramatically improved cell viability, decreased reactive oxygen species (ROS) levels, motor behavior...
Enhanced cardiac sympathetic afferent reflex (CSAR) contributes to ventricular arrhythmia (VA) after acute myocardial infarction (AMI). However, central regulation mechanisms remain unknown. The aim of this study was investigate whether local ablation (LCSAA) could reduce VA by inhibiting activated astrocytes in the hypothalamus paraventricular (PVN) an AMI rat model. rats were randomly divided into AMI, + BD (baroreceptor denervation), LCSAA and BD+ groups. Before generation (or) performed....
To investigate the effect of electroacupuncture on P35/P25-cyclin-dependent kinase 5 (CDK5)-Tau pathway in rats with Alzheimer's disease (AD), as well mechanism prevention and treatment AD.Sprague-Dawley were randomly divided into control group, sham-operation model 12 each group. A rat AD was established by injection Aβ25-35 bilateral hippocampus. The group given at "Baihui" (GV20) "Shenshu" (BL23) once a day, 15 min time, for 10 days. Morris water maze used to evaluate learning memory...
Fenretinide (4-HPR), a synthetic retinoid, has shown its antitumor activity in many tumor types with low cytotoxicity to normal cells and high clinical safety. However, the water solubility limits further biological applications. To increase solubility, 4-HPR was conjugated methoxy polyethylene glycol carboxylic acid (mPEG2K-COOH) by an ester linkage between phenol hydroxyl of carboxyl mPEG2K-COOH. The 4-HPR-PEG2K conjugate micelles had mean size 76.70 ± 1.248 nm narrow distribution critical...
Clinical application of doxorubicin (Dox) is limited due to its serious side effects including nephrotoxicity, and kidney podocytes play important roles in renal diseases. MicroRNAs (miRNAs) are critical regulators associated with human The purpose this study was explore a novel target adjusting Dox-induced podocyte injury. Through double luciferase reporter gene experiment, it found that miR-874-3p directly targeted methionine sulfoxide reductase B3 (MsrB3). During the tests inhibitor MsrB3...
Vascular endothelial injury (VEI) is an early event of atherosclerosis, and reversing dysfunction has become a new trend in the prevention treatment cardiovascular diseases. Hengshun aromatic vinegar (HSAV), traditional vinegar, been reported to have many pharmacological activities, but its effect against VEI molecular mechanism are still unknown. In this study, effects HSAV on were evaluated H 2 O -induced human umbilical vein cells (HUVECs) methionine-induced rats. Results showed that...