A5047911106- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- HIV/AIDS Research and Interventions
- Toxoplasma gondii Research Studies
- Breast Cancer Treatment Studies
- HIV Research and Treatment
- Medical Imaging Techniques and Applications
- Colorectal Cancer Treatments and Studies
- Sarcoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Antimicrobial Peptides and Activities
- Endometrial and Cervical Cancer Treatments
- Antimicrobial agents and applications
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Lung Cancer Treatments and Mutations
- Herpesvirus Infections and Treatments
- HIV, Drug Use, Sexual Risk
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Neuroimaging Techniques and Applications
- Neurosurgical Procedures and Complications
- Synthesis and Characterization of Heterocyclic Compounds
Kunming Medical University
2016-2025
Shandong University of Technology
2025
Fudan University
2014-2024
Center for Disease Control
2024
Community Health Center
2024
Lanzhou Veterinary Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Lanzhou University
2024
Yixing People's Hospital
2024
Jiangsu University
2024
We evaluated the performance of newly proposed radiomics multiparametric MRI (RMM), developed and validated based on a multicenter dataset adopting radiomic strategy, for pretreatment prediction pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer.A total 586 potentially eligible patients were retrospectively enrolled from four hospitals (primary cohort external validation 1-3). Quantitative imaging features extracted T2-weighted imaging, diffusion-weighted...
Abstract Distant metastasis (DM) is the main cause of treatment failure in locally advanced rectal cancer. Adjuvant chemotherapy usually used for distant control. However, not all patients can benefit from adjuvant chemotherapy, and particularly, some may even get worse outcomes after treatment. We develop validate an MRI-based radiomic signature (RS) prediction DM within a multicenter dataset. The RS proved to be independent prognostic factor as it only demonstrates good accuracy...
Imidazolium (Im), quaternary ammonium (Qa), and 1,4-diazabicyclo[2.2.2]octane-1,4-diium (DABCO-diium) cation-based small molecule cationic compounds their corresponding side-chain/main-chain polymers were synthesized.
Accurate predictions of distant metastasis (DM) in locally advanced rectal cancer (LARC) patients receiving neoadjuvant chemoradiotherapy (nCRT) are helpful developing appropriate treatment plans. This study aimed to perform DM prediction through deep learning radiomics.We retrospectively sampled 235 nCRT with the minimum 36 months' postoperative follow-up from three hospitals. Through transfer learning, a radiomic signature (DLRS) based on multiparametric magnetic resonance imaging (MRI)...
Pre-treatment survival prediction plays a key role in many diseases. We aimed to determine the prognostic value of pre-treatment Magnetic Resonance Imaging (MRI) based radiomic score for disease-free (DFS) patients with early-stage (IB-IIA) cervical cancer. Methods: A total 248 cancer underwent radical hysterectomy were included from two institutions between January 1, 2011 and December 31, 2017, whose MR imaging data, clinicopathological data DFS collected. Patients randomly divided into...
<h3>Importance</h3> Accurate identification of lymph node metastasis preoperatively and noninvasively in patients with cervical cancer can avoid unnecessary surgical intervention benefit treatment planning. <h3>Objective</h3> To develop a deep learning model using preoperative magnetic resonance imaging for prediction cancer. <h3>Design, Setting, Participants</h3> This diagnostic study developed an end-to-end to identify (MRI). A total 894 stage IB IIB who underwent radical hysterectomy...
Gram-negative bacteria, containing toxic proinflammatory and pyrogenic substances [endotoxin or lipopolysaccharide (LPS)], can lead to infection associated serious diseases, such as sepsis septic shock. Development of antimicrobial materials with intrinsically endotoxin adsorption activity prevent the release bacterial components while killing bacteria. Herein, a series imidazolium-type polyurethane (PU) foams properties were synthesized. The content effects cationic moieties on activities...
The standard treatment for patients with locally advanced gastric cancer has relied on perioperative radio-chemotherapy or chemotherapy and surgery. aim of this study was to investigate the wealth radiomics pre-treatment computed tomography (CT) in prediction pathological response preoperative chemotherapy.Thirty consecutive CT-staged II/III receiving neoadjuvant were enrolled between December 2014 March 2017. All underwent upper abdominal CT during unenhanced, late arterial phase (AP)...
Long-lived individuals have been extensively studied as a model to investigate the role of gut microbiota in aging, but their fungi remain almost unexplored. Here, we recruited community-dwelling cohort 251 participants (24–108 years, including 47 centenarians) from Guangxi China characterize mycobiome signatures. We found markedly varied during aging and determined predominant factor driving these variations. For long-lived individuals, core taxa, Penicillium Aspergillus, were maintained...
Although piperine can inhibit cells of tumors, the poor water solubility restricted its clinical application. This paper aimed to develop mixed micelles based on Soluplus® and D-α-tocopherol polyethylene glycol succinate (TPGS) improve aqueous anti-cancer effect.Piperine-loaded were prepared using a thin-film hydration method, their physicochemical properties characterized. The cellular uptake was confirmed by confocal laser scanning microscopy in A549 lung cancer HepG2 liver cells. In...
A predictive model was developed based on enhanced computed tomography (CT), laboratory test results, and pathological indicators to achieve the convenient effective prediction of single lymph node metastasis (LNM) in gastric cancer. Sixty-six consecutive patients (235 regional nodes) with pathologically confirmed cancer who underwent surgery at our hospital between December 2020 November 2021 were retrospectively reviewed. They randomly allocated training (n = 38, number nodes 119)...
Recently, metal peroxides with the ability to self-supply H2O2 have been intensively used in antibacterial and cancer therapy. However, performances are unsatisfactory due low efficiency of peroxide-mediated Fenton-like reaction. In this work, a novel zinc cerium bimetallic peroxide (CeZnOx) has first reported, which possesses acid-activated POD-like, OXD-like, CAT-like multienzymatic activities for efficiently bacterial inhibition. Specifically, CeZnOx self-supplying under weakly acidic...
Whether preoperative serum carbohydrate antigen 19-9 (CA19-9) is an independent prognostic factor and there are interactions of CA19-9 with carcinoembryonic (CEA) on the risk recurrence in colorectal cancer (CRC) patients still not clarified.Consecutive CRC who underwent curative resection for stage II-III adenocarcinoma at five hospitals were collected. Based Cox models, associations recurrence-free survival (RFS) overall (OS) evaluated or without elevated CEA, between CEA also calculated....
In this study, mixed micelles of Soluplus® and TPGS were developed for co-administering docetaxel (DTX) piperine (PIP) exerting the synergistic effect, which increased cytotoxicity improved anti-cancer activity in HepG2 cell lines compared to free DTX. These vitro (MTT assay, intracellular uptake micelles) vivo (pharmacokinetic immunostaining, TUNEL analysis) studies exhibited advantages co-delivery anticancer drugs with Soluplus®/TPGS by furthermore established that DTX PIP via could be a...
Purpose: This study aimed to develop and validate a nomogram for predicting the malignancy of small (8–20 mm) solid indeterminate solitary pulmonary nodules (SPNs) in Chinese population by using routine clinical computed tomography data. Methods: The prediction model was developed retrospective cohort that comprised 493 consecutive patients with SPNs who were treated between December 2012 2016. independently validated second comprising 216 January 2017 May 2018. investigated variables...
Fenretinide (4-HPR), as a semi-synthetic retinoid, has apoptosis-promoting effects single agent and chemotherapy synergist in vitro. When human ovarian cancer cells line (A2780s) was treated with both PTX 4-HPR, there synergistic anti-cancer effect demonstrated average combination index of 0.44. In this research, new TPGS-Soluplus® mixed micelles were developed which encapsulation efficiencies paclitaxel (PTX) fenretinide (4-HPR) high 98%, the diameter 66.26 nm. Cytotoxicity co-delivered...
Preoperative assessment of lymphovascular invasion (LVI) in invasive breast cancer (IBC) is high clinical relevance for treatment decision-making and prognosis.To investigate the associations preoperative magnetic resonance imaging (MRI) characteristics with LVI disease-free survival (DFS) by using machine learning methods patients IBC.Retrospective.Five hundred seventy-five women (range: 24-79 years) IBC who underwent MRI examinations at two hospitals, divided into training (N = 386)...
Primary pontine hemorrhage (PPH) is a particularly grave form of hemorrhagic stroke, characterized by its significant mortality rate. stereotactic hematoma puncture and drainage procedure that has been shown to improve the prognosis patients with PPH. However, there are currently no established criteria for selecting this procedure. We contrasted clinical outcomes PPH treated those who received conservative treatment in study. conducted logistic regression analysis identify risk factors...