A5104096874- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Remote Sensing and Land Use
- Adversarial Robustness in Machine Learning
- Environmental Changes in China
- Cancer therapeutics and mechanisms
- Anomaly Detection Techniques and Applications
- Advancements in Battery Materials
- Cancer, Hypoxia, and Metabolism
- Poisoning and overdose treatments
- Advanced biosensing and bioanalysis techniques
- Potassium and Related Disorders
- Peer-to-Peer Network Technologies
- Atmospheric and Environmental Gas Dynamics
- Metabolism and Genetic Disorders
- Inflammatory mediators and NSAID effects
- Air Quality and Health Impacts
- Plant Ecology and Soil Science
- Stochastic Gradient Optimization Techniques
- Ubiquitin and proteasome pathways
- Aldose Reductase and Taurine
- Energy, Environment, Economic Growth
- Epigenetics and DNA Methylation
- Advanced Technologies in Various Fields
- Vitamin D Research Studies
Tianjin Medical University Cancer Institute and Hospital
2024
FirstUnion (China)
2023
Mayo Clinic in Arizona
2023
PetroChina Southwest Oil and Gas Field Company (China)
2023
Lanzhou University
2009-2022
Hunan University of Technology
2016-2017
Central South University
2013
China Pharmaceutical University
2007-2012
Jiangmen Central Hospital
2011
Sun Yat-sen University
2010
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInactivation of medium-chain acyl-CoA dehydrogenase by a metabolite hypoglycin: characterization the major turnover product and evidence suggesting an alternative flavin modification pathwayMing Tain Lai, Ding Li, Eugene Oh, Hung Wen LiuCite this: J. Am. Chem. Soc. 1993, 115, 5, 1619–1628Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March...
Background: Hypoxia induces hepatocellular carcinoma (HCC) malignancies; yet it also offers treatment opportunities, exemplified by developing hypoxia-activated prodrugs (HAPs).Although HAP TH-302 combined with therapeutic antibody (Ab) has synergistic effects, the clinical benefits are limited on-target off-tumor toxicity of Ab.Here, we sought to develop a anti-M2 splice isoform pyruvate kinase (PKM2) Ab for potentiated targeting therapy.Methods: Codon-optimized and hypoxia-activation...
Abstract Tight gas belongs to unconventional reservoirs, and obtain high production, it needs be fractured reformed. After the construction is completed, a large amount of flowback fluid produced. In order reduce cost treatment avoid environmental pollution, slippery water system with usually used on site hydraulic fracturing. Almost all fluids contain high‐order cations such as calcium ions, magnesium iron suspended solids. Some incomplete gel‐breaking micelles unseparated condensate oil....
This study aimed to investigate the transport capability of nicotine across Calu-3 cell monolayer in various forms, including freebase, salts, and flavored e-liquids with benzoate.Nicotine is rapidly absorbed from respiratory system into systemic circulation during e-cigarettes use. However, mechanism lung has not been well understood yet. may offer critical biological evidence have implications for use regulation e-cigarettes.The viability cells after administration salts representative...
Based on ground monitoring data, we explored the spatiotemporal characteristics and drivers of PM2.5 in Yangtze River Economic Belt (YREB) 2018 using spatial autocorrelation analysis geodetector modeling methods. The results showed that:① concentration YREB posed obvious low values summer high winter, seasonal variation spring autumn, monthly U-shaped variation, daily pulse variation. value area was mainly concentrated south bank upper reaches, whereas located north middle-lower reaches...
A village-scale approach was developed to break the cycle between desertification and poverty by providing sustainable employment income, promoting environmental restoration reducing water consumption, integrating amelioration with ensure that solving one problem does not create new ones. The advantages of high-efficiency water-saving planting, a profitable livestock system, sand-processing industry, sand control afforestation are integrated into what we call Zhengxin pattern, which offers...
Objective To develop an HPLC-UV assay for the determination of levofloxacin in human plasma, and evaluate pharmacokinetics bioequivalence. Methods After being deproteined by perchloric acid (20%, v/v), samples were separated HPLC on a reversed-phase C18 column with mobile phase water-acetonitrile- triethylamine-acetic (81∶19∶0.5∶1, V/V/V/V)and flow rate 1.0 ml · min-1. A randomized crossover design was performed 20 healthy volunteers. In two study periods, single dose tablets administered to...
Abstract Metastatic pancreatic cancer patients who previously progressed on nab-paclitaxel/gemcitabine (average of 3 previous lines if treatment) were treated with elraglusib in combination a rechallenge this combination. The majority demonstrated prolonged progression free survival. While early clinical evidence is highly encouraging, the biological determinants response are unknown. In vitro screens PDX cell showed that some tumor cells possess modest intrinsic resistance to as measured by...
Land use/cover change (LUCC) is one of the most important fields study in global environmental research. Decades dynamic cropland caused by human activities an topic LUCC Minqin located Gansu province northwest China, where landscape configuration fragile. In recent years, problems such as vegetation destruction and desertification became more serious. And there was a huge Minqin's cropland, which factor to this area. Through integration Geography Information System (GIS) Remote Sensing (RS)...