Abstract Objectives The inflammatory cascade and cell death post-myocardial ischemia reperfusion (MI/R) are very complex. Despite the understanding that macrophage inflammation has a pivotal role in pathophysiology of MI/R, contribution signals tailoring function vascular endothelium remains unknown. Materials methods In present study, we analyzed effects NEDD4 on NLRP3 inflammasome activation-mediated pyroptosis vitro after an acute pro-inflammatory stimulus vivo MI/R mouse model. TTC...

To evaluate the role of CHADS2 and CHA2DS2-VASc scores in predicting risk ischemic stroke or transient attack (TIA) outcomes patients with interatrial block (IAB) without a history atrial fibrillation (AF).A retrospective study was conducted, including 1,046 non-anticoagulated inpatients (612 males, 434 females; mean age: 63±10 years) IAB AF. defined as P-wave duration ＞120 ms using 12-lead electrocardiogram. were retrospectively calculated. The primary evaluated TIA.During follow-up period...

Abstract Background Myocardial reperfusion injury is often accompanied by cell death and inflammatory reactions. Recently, pyroptosis gradually recognized as pivotal role in cardiovascular disease. However, little known about the regulatory of beclin1 control caspase-4 activation pyroptosis. The present study confirmed whether regulates mediated thereby protects Human Cardiac microvascular endothelial cells (HCMECs) against injury. Methods TTC Evan's blue dye, western blot,...

Previous studies have demonstrated that the aberrant expression of Wnt5a occurs in atherosclerotic lesions. However, precise role pathogenesis atherosclerosis remains largely unknown. The present study was undertaken to determine whether RNA interference vivo by adenovirus (Ad)-mediated small interfering (siRNA) transfection is capable inhibiting progression atherosclerosis. Recombinant carrying siRNA targeting (Ad-Wnt5a siRNA) designed. Male apolipoprotein E-deficient (ApoE-/-) mice were...

Interatrial block (IAB) is associated with an increased risk of atrial fibrillation (AF). The aim this retrospective study was to investigate the association a combination IAB and CHADS2 score, AF-related score for ischemic stroke, new onset AF in patients sinus rhythm. A total 1,571 (803 males, 768 females; mean age: 58 ± 16 years) were included study. defined as P-wave duration > 120 ms 12-lead electrocardiogram, high ≥ 2 points. During follow-up period 4.8 0.7 years, occurred 122 (16.1...

The value of the right bundle branch block (RBBB) in treatment acute myocardial infarction remains unclear. Studies on RBBB may significantly influence infarction. A total 845 patients with who underwent primary coronary angiography at Henan Provincial People's Hospital were analyzed. Higher peak enzyme levels, a higher ratio Killip ≥II and closer proximal occlusion infarct‑related artery (IRA) observed compared those without. TIMI flow 0/1 IRA received percutaneous intervention (PCI) to...

The aim of this study was to explore the effect atorvastatin intervention on plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and inflammatory cytokine levels in patients with heart failure (HF). One hundred twenty-three HF were selected from our hospital randomly divided into control (N = 61) observation 62) groups; former received conventional treatment, while latter given treatment combined atorvastatin. Plasma NT-proBNP, cytokines [high-sensitive C-reactive protein (hs-CRP),...

BACKGROUND This study sought to compare the 30-day and 1-year survival of patients diagnosed with ST-segment elevation myocardial infarction (STEMI), whose symptom onset in-hospital first medical contact (IHFMC) was 3-6 h, who received either thrombolysis (IHT) in nearest county hospital or direct transfer a larger Henan province, China for primary percutaneous coronary intervention (PPCI). MATERIAL AND METHODS Patients were allocated into 2 groups: one group IHT local hospital, whereas...

To investigate the reperfusion time in patients with ST-segment elevation myocardial infarction (STEMI) Henan Province, China, and discuss strategies for shortening that period.The times of 1556 STEMI cases 30 hospitals Province were analyzed from January 2008 to August 2012, including 736 provincial hospitals, 462 municipal 358 country hospitals. The following data: Time period 1 (from symptom onset first medical contact), 2 contact diagnosis), 3 diagnosis providing consent), 4 consent...

Enhanced cardiac sympathetic afferent reflex (CSAR) contributes to ventricular arrhythmia (VA) after acute myocardial infarction (AMI). However, central regulation mechanisms remain unknown. The aim of this study was investigate whether local ablation (LCSAA) could reduce VA by inhibiting activated astrocytes in the hypothalamus paraventricular (PVN) an AMI rat model. rats were randomly divided into AMI, + BD (baroreceptor denervation), LCSAA and BD+ groups. Before generation (or) performed....

Ethanol infusion of the vein Marshall (EI-VOM) has been widely used to facilitate mitral isthmus (MI) ablation. According literature, success rate achieving a bidirectional conduction block across MI ranges from 51 96%, with no standardized strategy or method available for cardiac electrophysiologists.This study aimed introduce and evaluate novel ablation MI.Consecutive patients persistent atrial fibrillation (PeAF) that underwent catheter were included. The procedure followed stepwise...

Paroxysmal atrial fibrillation (AF) frequently occurs in patients with Wolff-Parkinson-White (WPW) syndrome. Although successful ablation of the accessory pathway (AP) eliminates paroxysmal AF some patients, other it can recur.We investigated clinical utility advanced interatrial block (IAB) for predicting risk recurrence verified and WPW syndrome after AP ablation.This retrospective study included 103 (70 men, 33 women; mean age, 44 ± 16 years) who had AF. A resting 12-lead...

Fondaparinux and enoxaparin are used in patients with acute coronary syndrome (ACS), but their effect particular populations of is not well known. The objective was to explore the difference between fondaparinux non-ST elevation ACS (NSTE-ACS) treated percutaneous intervention (PCI) tirofiban.We prospectively enrolled 461 NSTE-ACS PCI, tirofiban, either (n = 229) or 232). Death, myocardial infarction, recurrent ischaemia its composite outcome were assessed. incidences major minor bleeding...

Objective To investigate differences in clinical and angiographic outcomes between patients with acute myocardial infarction red white thrombi. Methods A total of 137 ST-segment elevation undergoing primary percutaneous coronary interventions were included. Thrombus material was classified as or based on its pathology. Information characteristics thrombi available for 97 (70.8%) patients. Results The ischaemic time significantly longer the thrombus group compared group. incidence major...

BACKGROUND In this study, cardiac magnetic resonance imaging was used to investigate the characteristics of patients who have total coronary occlusion but manifest with non-ST-segment elevation myocardial infarction (NSTEMI), and we assessed extent infarct transmurality necrosis size in NSTEMI patients. MATERIAL AND METHODS We enrolled all diagnosed at our hospital subtotal or culprit artery (TOCA), based on angiography, successfully underwent PCI within 12 h admission, had CMR performed 2...

The strategy of ablation index (AI)-guided high-power seems to be a novel for performing pulmonary vein isolation (PVI). An AI-guided was used in this study determine whether superior vena cava (SVCI) after PVI feasible and safe patients with AF.Data from 53 AF were collected. Mapping SVC performed. applied power set at 45 W the procedure guided by AI. divided into six segments cranial view. RF applications AI values different compared analyzed. Using receiver operating characteristic (ROC)...

Fuel quality especially biodiesel is highly dependent to its water content and the major sources of in fuels relates transportation, production, storage process. In this present contribution, a complete explanation powerful PSO algorithm coupled with ANFIS strategy was utilized account diesel mixtures based on temperature composition. Modeling results indicate that predicted values are good agreement extracted experimental datasets. Also, accuracy robustness ANFIS-PSO used for prediction...