A5041424937- Dental Health and Care Utilization
- Endodontics and Root Canal Treatments
- Oral microbiology and periodontitis research
- Dental Radiography and Imaging
- Bone Tissue Engineering Materials
- Pediatric health and respiratory diseases
- Vitamin D Research Studies
- MicroRNA in disease regulation
- Laser Applications in Dentistry and Medicine
- Genetics, Aging, and Longevity in Model Organisms
- Graphene and Nanomaterials Applications
- Dental materials and restorations
- Breastfeeding Practices and Influences
- Child Nutrition and Water Access
- dental development and anomalies
- Drilling and Well Engineering
- Bacterial biofilms and quorum sensing
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Oral and gingival health research
- Dental Erosion and Treatment
- Antimicrobial Peptides and Activities
- Signaling Pathways in Disease
- Hand Gesture Recognition Systems
Shandong University
2011-2024
Jinan Stomatological Hospital
2024
Stomatology Hospital
2024
Wuhan Ship Development & Design Institute
2017
Shanghai Medical College of Fudan University
2013
Huazhong University of Science and Technology
2010
Tongji Hospital
2010
Shandong First Medical University
2001
Oral squamous cell carcinoma (OSCC) is currently a highly prevalent disease worldwide. Cisplatin (CDDP) widely used for the chemotherapy of OSCC. Yet, molecular mechanisms responsible cisplatin resistance have not been fully elucidated. In this study, we showed that overexpression p21 (RAC1) activated kinase 1 (PAK1) induced epithelial to mesenchymal transition (EMT) and significantly promoted invasion migration oral SCC25 cells. Emerging evidence indicates strong link between therapy...
The purpose of this study was to conduct a cone-beam computed tomographic (CBCT) investigation on the root and canal configuration mandibular first molars, especially morphology disto-lingual (DL) root, in Chinese subpopulation. A total 910 CBCT images molars were collected from 455 patients who underwent examinations as preoperative assessment for implants or orthodontic treatment. following information analyzed evaluated: tooth position, gender, number per tooth, type mesial root(s) distal...
To investigate the bactericidal activity of lactoferrin-derived peptides and a new LF-derived chimera (LFchimera) against P. aeruginosa influence on virulence factors aeruginosa.Lactoferricin (LFcin) lactoferrampin (LFampin) are highly bioactive isolated from N-terminal region lactoferrin (LF) by pepsin digestion. In this study, we designed LFchimera containing LFcin amino acids 17-30 LFampin 268-284. Pseudomonas cells were incubated in medium with at different concentrations, then assays...
Despite titanium (Ti) implants have been commonly used in the medical device field due to their superior biocompatibility, implant-associated bacterial infection remains a major clinical complication. Nanosilver, an effective antibacterial agent against wide spectrum of strains, with low-resistance potential, has attracted much interest too. Incorporation nanosilver on Ti may be promising approach prevent biofilm formation.The objective study was investigate effects and osteoinductive...
Objective: The current study aimed to explore the function of miR-638 on progression oral squamous cell carcinoma (OSCC) and relevant molecular mechanisms.Methods: Expression profile in OSCC tissues cells was detected using quantitative real-time polymerase chain reaction (qRT-PCR) method. Chi-square test performed estimate relationship between clinical parameters cases. Cell viability motility abilities were estimated MTT transwell assays, respectively. Potential targets identified through...
Abstract Background The high prevalence of early childhood caries (ECC) is widespread around the world, and oral health education (OHE) plays a vital role in preventing ECC. Numerous studies on ECC risk factor assessment have assisted us enriching content OHE. objective this study was to further assess independent factors for at different ages provide evidence insights Methods Children aged 3–5 years old ( N = 1301) Shandong Province were enrolled cross-sectional study. Data about status...
As commonly bone defect is a disease of jaw that can seriously affect implant restoration, the bioactive scaffold be used as potential systems to provide effective repair for defect.A osteoinductive tissue engineering has been prepared in order explore effect materials on engineering.In this study, NELL-1 nanoparticles (Chi/NNP) and nano hydroxyapatite were incorporated composite scaffolds by electrospinning characterized using TEM, SEM, contact angle, tensile tests vitro drug release. In...
This research aimed to explore the function of protease activated receptor 2 (
Early childhood caries is a multifactorial disease involving interactions between genetic and environmental risk factors. The aim of this study was to examine the effects vitamin D receptor (VDR) gene polymorphisms gene-environment on etiology of, susceptibility to, in Chinese children aged 3-5 years.Children (n = 549) were divided into three groups according risk: high (decayed, missing, filled teeth (dmft) index > 4; n 148), moderate (dmft 1-4; 156), caries-free 245). A questionnaire...
Debris extrusion from the apical foramen can be problematic in severely curved canals. This study aimed to assess use of Twisted Files (TF) at different rotational speeds during retreatment, compared with manual technique using Triple-Flex (TFF). Forty-eight mesiobuccal root canals were randomized four groups (n = 12 per group). In A, B, and C, gutta-percha was removed TF 500, 1000, 1500 rpm, respectively, while it TFF group D. Apical debris collected a pre-weighed centrifuge tube. The...
The purpose of this study was the evaluation potential and mechanism phenytoin to promote differentiation human dental pulp stem cells (hDPSC) into odontoblasts/osteoblasts.Fourth-generation hDPSC originating from healthy third molars cultured in control as well phenytoin-containing media (PHT) for 14 days. qPCR applied detect expression DSPP, DMP1, ALP genes. Western blot analysis used confirm findings. One-way variance (ANOVA) statistical (p < 0.05). Information about assessed PubChem...
Abstract Background: The high prevalence of early childhood caries (ECC) is widespread around the world, and oral health education (OHE) plays a vital role in preventing ECC. Numerous studies on ECC risk factor assessment have assisted us enrich content OHE. objective this study, while, was to further assess independent factors for at different ages provide evidence insight Methods : Data about status, knowledge, attitude, practice (KAP) from questionnaire completed by caregivers among...
Reinforcement Learning from Human Feedback (RLHF) has proven highly effective in aligning Large Language Models (LLMs) with human preferences. However, the original RLHF typically optimizes under an overall reward, which can lead to a suboptimal learning process. This limitation stems RLHF's lack of awareness regarding specific tokens should be reinforced or suppressed. Moreover, conflicts supervision arise, for instance, when chosen response includes erroneous tokens, while rejected...