A5017061001- Catalysis and Hydrodesulfurization Studies
- Photochemistry and Electron Transfer Studies
- Electrocatalysts for Energy Conversion
- Advanced Fiber Laser Technologies
- Spectroscopy and Laser Applications
- Nanomaterials for catalytic reactions
- Catalytic Processes in Materials Science
- Advanced Photocatalysis Techniques
- Polyoxometalates: Synthesis and Applications
- Radical Photochemical Reactions
- Photochromic and Fluorescence Chemistry
- Molecular spectroscopy and chirality
- Ubiquitin and proteasome pathways
- Spectroscopy and Quantum Chemical Studies
- MXene and MAX Phase Materials
- Advanced Chemical Physics Studies
- Air Quality and Health Impacts
- Laser-Matter Interactions and Applications
- Cancer-related Molecular Pathways
- Thermal and Kinetic Analysis
- Photonic and Optical Devices
- Molecular Spectroscopy and Structure
- Glycosylation and Glycoproteins Research
- Industrial Gas Emission Control
- Free Radicals and Antioxidants
Peking University
2017-2025
Chaohu University
2023-2025
Shandong Academy of Environmental Science
2024
Center for Life Sciences
2024
North University of China
2019-2023
National Astronomical Observatories
2019-2023
Kavli Institute for Theoretical Sciences
2023
International Centre for Radio Astronomy Research
2023
The University of Western Australia
2023
State Key Joint Laboratory of Environment Simulation and Pollution Control
2017-2020
Abstract Shieldin, including SHLD1, SHLD2, SHLD3 and REV7, functions as a bridge linking 53BP1-RIF1 single-strand DNA to suppress the termini nucleolytic resection during non-homologous end joining (NHEJ). However, mechanism of shieldin assembly remains unclear. Here we present crystal structure SHLD3-REV7-SHLD2 ternary complex reveal an unexpected C (closed)-REV7-O (open)-REV7 conformational dimer mediated by SHLD3. We show that SHLD2 interacts with O-REV7 N-terminus forming β sheet...
Abstract Cullin-RING E3 ubiquitin ligase (CRL) family members play critical roles in numerous biological processes and diseases including cancer Alzheimer’s disease. Oligomerization of CRLs has been reported to be crucial for the regulation their activities. However, structural basis its mechanism oligomerization are not fully known. Here, we present cryo-EM structures oligomeric CRL2 FEM1B unneddylated state, neddylated state complex with BEX2 as well FNIP1/FLCN. These reveal that...
Developing clean and renewable energy technologies requires the design of efficient bifunctional catalysts that do not rely on inert metals for electrochemical water splitting. This study introduced a novel three-step strategy to fabricate NiCoFe-modified MoNi4/MoO2 nanowires supported nickel foam substrates (denoted as NiCoFe-MoNi4/MoO2/NF), which demonstrate excellent catalytic performance with an impressively low overpotential just 13 mV at 10 mA·cm–2 current density hydrogen evolution...
A novel tungsten-based heterojunction nanocomposite material was developed for the efficient oxidative desulfurization (ODS) of fuel oil, enabling production low-sulfur and a reduction in harmful SOx emissions. In this material, WC/W2C uniformly immobilized on porous nitrogen-doped carbon (NC) matrix structure through facile situ pyrolysis polyaniline-phosphotungstic acid (PANI/PTA) precursors. The resultant WC/W2C@NC catalyst demonstrated remarkable performance, achieving 100% removal 4000...
Clathrin-mediated endocytosis (CME) is the process by which clathrin assembles on plasma membrane to form clathrin-coated pits (CCPs), then invaginate, accumulate cargo and are released fission from vesicles (CCVs). A transition of nascent CCPs flat-to-curved has been observed various methods. However, what drives this remains unknown controversial. GAK its chaperone protein, Hsc70, well-known mediate release CCVs several studies have a late burst recruitment as form. Other proposed that...
Inorganic phosphate (Pi) is essential for life, and its intracellular levels must be tightly regulated to avoid toxicity. XPR1, the sole known exporter, critical maintaining this balance. Here we report cryo-EM structures of human XPR1-KIDINS220 complex in substrate-free closed substrate-bound outward-open states, as well an XPR1 mutant a inward-facing state. In presence inositol hexaphosphate (InsP6) phosphate, adopts conformation, with InsP6 binding SPX domain juxtamembrane regions,...
High‐entropy nitrides (HENs) are emerging as promising electrocatalysts due to their diverse elemental composition, tunable electrochemical properties, and a wide range of active sites that enhance adsorption oxidation reactions. However, the unclear role entropy has limited full potential in electrocatalysis. In this study, we introduce novel straightforward method for synthesizing (CoNiCuVW)N with variable levels using halite molten salt. By exploiting synergistic effects multiple metal...
A combined femtosecond Kerr gated time-resolved fluorescence (fs-KTRF) and picosecond resonance Raman (ps-KTR(3)) study is reported for two p-hydroxyphenacyl (pHP) caged phototriggers, HPDP HPA, in neat acetonitrile water/acetonitrile (1:1 by volume) solvents. Fs-KTRF spectroscopy was employed to characterize the spectral properties dynamics of singlet excited states, ps-KTR(3) used monitor formation subsequent reaction triplet state. These results provide important evidence elucidation...
Objective: Our objective was to examine the mechanisms via which exenatide attenuates postprandial hyperglycemia in type 2 diabetes mellitus (T2DM). Study Design: Seventeen T2DM patients (44 yr; seven females, 10 males; body mass index = 33.6 kg/m2; glycosylated hemoglobin 7.9%) received a mixed meal followed for 6 h with double-tracer technique ([1-14C]glucose orally; [3-3H]glucose iv) before and after wk of exenatide. In protocol II (n 5), but not I 12), given morning repeat meal. Total...
BTR1 (SLC4A11) is a NH3 stimulated H+ (OH-) transporter belonging to the SLC4 family. Dysfunction of leads diseases such as congenital hereditary endothelial dystrophy (CHED) and Fuchs corneal (FECD). However, mechanistic basis activation by alkaline pH, transport activity regulation pathogenic mutations remains elusive. Here, we present cryo-EM structures human in outward-facing state complex with its activating ligands PIP2 inward-facing R125H mutation. We reveal that binds at interface...
Abstract Anion exchanger 2 (AE2) is an electroneutral Na + -independent Cl - /HCO 3 belongs to the SLC4 transporter family. The widely expressed AE2 participates in a variety of physiological processes, including transepithelial acid-base secretion and osteoclastogenesis. Both transmembrane domains (TMDs) N-terminal cytoplasmic domain (NTD) are involved regulation activity. However, regulatory mechanism remains unclear. Here, we report 3.2 Å cryo-EM structure TMDs complex with PIP 3.3...
Abstract The CUL3-RING E3 ubiquitin ligases (CRL3s) play an essential role in response to extracellular nutrition and stress stimuli. ligase function of CRL3s is activated through dimerization. However, how why such a dimeric assembly required for its activity remains elusive. Here, we report the cryo-EM structure CRL3 KLHL22 complex reveal conserved N-terminal motif CUL3 that contributes dimerization . We show deletion impairs both several other CRL3s. In addition, found dynamics generates...
To investigate the bactericidal activity of lactoferrin-derived peptides and a new LF-derived chimera (LFchimera) against P. aeruginosa influence on virulence factors aeruginosa.Lactoferricin (LFcin) lactoferrampin (LFampin) are highly bioactive isolated from N-terminal region lactoferrin (LF) by pepsin digestion. In this study, we designed LFchimera containing LFcin amino acids 17-30 LFampin 268-284. Pseudomonas cells were incubated in medium with at different concentrations, then assays...