A5073491424- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Infectious Diseases and Mycology
- Plant Pathogens and Fungal Diseases
- Mycotoxins in Agriculture and Food
- Fungal Plant Pathogen Control
- Photodynamic Therapy Research Studies
- Essential Oils and Antimicrobial Activity
- Cancer, Lipids, and Metabolism
- Bacterial biofilms and quorum sensing
- Circular RNAs in diseases
- COVID-19 Clinical Research Studies
- Nanoplatforms for cancer theranostics
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Long-Term Effects of COVID-19
- Plasma Applications and Diagnostics
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Ocular Infections and Treatments
- Inflammatory mediators and NSAID effects
- Cell Adhesion Molecules Research
- Receptor Mechanisms and Signaling
- Microbial Natural Products and Biosynthesis
Yangtze University
2016-2025
Institute of Computing Technology
2024
Chinese Academy of Sciences
2024
Yunnan University
2024
Jingzhou Central Hospital
2015-2023
Fujian Medical University
2020-2023
Third Affiliated Hospital of Sun Yat-sen University
2023
Sun Yat-sen University
2023
Shaanxi Provincial People's Hospital
2022
Shanxi Medical University
2022
Coronavirus disease 2019 (COVID-19) can lead to serious illness and death, thus, it is particularly important predict the severity prognosis of COVID-19. The Sequential Organ Failure Assessment (SOFA) score has been used clinical outcomes patients with multiple organ failure requiring intensive care. Therefore, we retrospectively analyzed characteristics, risk factors, relationship between SOFA COVID-19 patients.We included all ≥18 years old who were diagnosed in laboratory continuously...
A microhollow cathode based, direct-current, atmospheric pressure, He/O2 (2%) cold plasma microjet was used to inactive antifungal resistants Candida albicans, krusei, and glabrata in air water. Effective inactivation (>90%) achieved 10 min 1 Antifungal susceptibility tests showed drastic reduction of the minimum inhibitory concentration after treatment. The attributed reactive oxygen species generated or Hydroxyl singlet molecular radicals were detected plasma-water system by...
We investigated the antifungal effect of non-thermal plasma, as well its combination with common drugs, against Candida biofilms. A direct current atmospheric pressure He/O2 (2%) plasma microjet (PMJ) was used to treat biofilms in a 96-well plate. Inactivation efficacies were evaluated by XTT assay and counting colony forming units (CFUs). Morphological properties Scanning Electron Microscope (SEM). The sessile minimal inhibitory concentrations (SMICs) fluconazole, amphotericin B,...
With voriconazole (VRC) being approved as the first choice in treating invasive aspergillosis (IA) and its increasing use treatment, a VRC-resistant strain of Aspergillus flavus, second leading cause IA after fumigatus, has emerged. The A. flavus was isolated for time from surgical lung specimen an patient with no response to VRC therapy. In order ascertain mechanism resistance, azole target enzyme genes this were cloned sequenced, 4 mutations generating amino acid residue substitutions...
Oral squamous cell carcinoma (OSCC) is currently a highly prevalent disease worldwide. Cisplatin (CDDP) widely used for the chemotherapy of OSCC. Yet, molecular mechanisms responsible cisplatin resistance have not been fully elucidated. In this study, we showed that overexpression p21 (RAC1) activated kinase 1 (PAK1) induced epithelial to mesenchymal transition (EMT) and significantly promoted invasion migration oral SCC25 cells. Emerging evidence indicates strong link between therapy...
Introduction Azole resistance has been increasingly reported and become an issue for clinical managements of invasive mycoses. New strategy with combination therapy arises as a valuable promising alternative option. The aim the present study is to investigate in vitro combinational effect proton pump inhibitors (PPIs) azoles against pathogenic fungi. Methods In interactions PPIs including omeprazole (OME), lansoprazole (LAN), pantoprazole (PAN), rabeprazole (RAB), commonly used itraconazole...
Background Invasive fungal infections (IFIs) constitute a significant health challenge, particularly among immunocompromised individuals, characterized by high prevalence and associated mortality rates. The synergistic administration of Baicalein (BE) with azole antifungal agents could potentially herald novel therapeutic paradigm. Materials methods 54 Aspergillus strains 23 dematiaceous fungi were selected. standard M38-A2 microbroth dilution method was used to test the minimum inhibitory...
ABSTRACT The growing resistance of Aspergillus to azoles poses a significant challenge in treating invasive fungal infections. This study aimed investigate the synergistic effect berbamine hydrochloride (BBM) combined with fumigatus and explore role efflux pump inhibition this synergy. efficacy combining BBM itraconazole (ITC), voriconazole (VOR), posaconazole (POS) was tested against 69 A . strains that had been identified using M38-A3 broth microdilution method. quantitative reverse...
<title>Abstract</title> Vitiligo is a chronic immune-related disorder characterized by depigmented skin patches due to melanocyte loss. Traditional treatments often fall short because of significant side effects and limited efficacy. This study evaluated the efficacy safety upadacitinib, selective JAK1 inhibitor, in treating stable nonsegmental vitiligo adults. We retrospectively analyzed 10 patients treated with upadacitinib at Jingzhou Hospital affiliated Yangtze University from November...
Dermatophytes are the most common cause of onychomycosis, counting for 90% fungal nail infection. Although dermatophyte pathogens normally susceptible to antifungal agents, onychomycosis often results in refractory chronic disease, and formation biofilms frequently underlines inadequate responses resistance standard treatment. Numerous vitro vivo antimicrobial photodynamic therapy (aPDT) studies have shown biofilm eradication or substantial reduction, however, such investigation has not yet...
Previously case reports showed dupilumab may benefit for hand eczema treatment, but relatively comprehensive assessments are lacking. A 45-year-old male with multiple severe vesicles, bullae and pustule on the palmar aspects of both foot diagnosed dyshidrotic by pathology was treated at an initial dose 600 mg subcutaneously, followed 300 every 2 weeks. The physician's assessment patient revealed excellent response to treatment dupilumab; lesions symptoms achieved dramatic improvement third...
MicroRNAs (miRNAs) have been shown to be involved in bladder cancer progression. miR-489 (also known as miR-489-3p) was recently reported a tumor suppressor several cancers. However, its exact role and mechanism the progression of are largely unknown. In this study, we explore proliferation invasion human cells. The expression levels were detected normal adjacent tissues, well epithelial cells cell lines. results showed that sharply reduced tissues Then mimic or oligo anta-miR-489...
The emergence of resistant Aspergillus spp. is increasing worldwide. Long-term susceptibility surveillance for clinically isolated strains warranted understanding the dynamic change in and monitoring resistance. Additionally, neither clinical breakpoints (CBPs) nor epidemiological cutoff values (ECVs) China have been established. In this study, we performed a 20-year antifungal 706 isolates laboratory at Peking University First Hospital from 1999 to 2019; vitro triazoles, caspofungin,...
Limited options of antifungals and the emergence drug resistance in fungal pathogens has been a multifaceted clinical challenge. Combination therapy represents valuable alternative to antifungal monotherapy.
The efficient targeting of drugs to tumor cell and subsequent rapid drug release remain primary challenges in the development nanomedicines for cancer therapy. Here, we constructed a glucose transporter 1 (GLUT1)-targeting microenvironment-sensitive Glucose-PEG-PAMAM-s-s-Camptothecin-Cy7 (GPCC) conjugate tackle dilemma. was characterized by small particle size, spherical shape, glutathione (GSH)-sensitive release. In vitro explored monolayer (2D) multilayer spheroid (3D) HepG2 models...
Candida species are the most common fungal pathogens to infect humans, and can cause life-threatening illnesses in individuals with compromised immune systems. Fluconazole (FLU) is frequently administered antifungal drug, but its therapeutic efficacy has been limited by emergence of drug-resistant strains. When co-administered minocycline (MIN), FLU synergistically treat clinical albicans isolates vitro vivo . However, there have few reports regarding synergistic MIN azoles when used...
Infections of Fusarium spp. and Exophiala are often chronic, recalcitrant, resulting in significant morbidity, causing discomfort, disfigurement, social isolation. Systemic disseminations happen compromised patients, which refractory to available antifungal therapies thereby lead death. The antimicrobial photodynamic therapy (aPDT) has been demonstrated effectively inactivate multiple pathogenic fungi is considered as a promising alternative treatment for mycoses. In the present study, we...