A5090477926- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Plant Pathogens and Fungal Diseases
- Infectious Diseases and Mycology
- Fungal Biology and Applications
- Mycotoxins in Agriculture and Food
- Advanced Memory and Neural Computing
- Peptidase Inhibition and Analysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Dermatology and Skin Diseases
- MicroRNA in disease regulation
- Oral Health Pathology and Treatment
- Essential Oils and Antimicrobial Activity
- Fungal and yeast genetics research
- CCD and CMOS Imaging Sensors
- Bacterial Identification and Susceptibility Testing
- Sinusitis and nasal conditions
- Electronic Packaging and Soldering Technologies
- Circular RNAs in diseases
- 3D IC and TSV technologies
- Psoriasis: Treatment and Pathogenesis
- Ferroelectric and Negative Capacitance Devices
- Immunodeficiency and Autoimmune Disorders
- Plant Pathogens and Resistance
Peking University
2016-2025
National Clinical Research Center for Digestive Diseases
2019-2025
Peking University First Hospital
2016-2025
Guiyang Medical University
2025
Guizhou Cancer Hospital
2025
China University of Petroleum, East China
2025
Institute of Software
2025
Chang'an University
2025
National Clinical Research
2025
Beijing Normal University
2021-2024
Optical imaging of nanoscale objects, whether it is based on scattering or fluorescence, a challenging task due to reduced detection signal-to-noise ratio and contrast at subwavelength dimensions. Here, we report field-portable fluorescence microscopy platform installed smart phone for individual nanoparticles as well viruses using lightweight compact opto-mechanical attachment the existing camera module cell phone. This hand-held fluorescent device utilizes (i) 450 nm laser diode that...
Abstract Sorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma (HCC). However, sorafenib resistance significantly limits its therapeutic efficacy, and mechanisms underlying have not been fully clarified. Here we report that a circular RNA, circRNA-SORE (a RNA upregulated in so rafenib- re sistant HCC cells), plays significant role HCC. We found sorafenib-resistant cells depletion of substantially increases cell-killing ability sorafenib. Further studies...
Abstract Background and aims Accumulating evidence suggests that the primary acquired resistance of hepatocellular carcinoma (HCC) to sorafenib is mediated by multiple molecular, cellular, microenvironmental mechanisms. Understanding these mechanisms will enhance likelihood effective therapy. Methods In vitro in vivo experiments were performed clinical samples online databases for investigation. Results this study, we found a circular RNA, circRNA-SORE, which up-regulated so...
To monitor changes in itraconazole susceptibility of isolates from a patient undergoing treatment for pulmonary Aspergillus infection and relate these to genotypic/phenotypic alterations.Six fumigatus were serially recovered the patient. Itraconazole MICs determined by Etest NCCLS methodology. Growth characteristics phenotype monitored. Molecular analysis included random amplified polymorphic DNA (RAPD) assay sequencing cyp51A gene.The MIC against first isolate before was 0.25 mg/L; second...
Abstract The treatment for hepatocellular carcinoma (HCC) is promising in recent years, but still facing critical challenges. first targeted therapy, sorafenib, prolonged the overall survival by months. However, resistance often occurs, largely limits its efficacy. Sorafenib was found to target electron transport chain complexes, which results generation of reactive oxygen species (ROS). To maintain sorafenib and further facilitate tumor progression, cancer cells develop strategies overcome...
Abstract HCC is a common malignancy worldwide and surgery or reginal treatments are deemed insufficient for advanced-stage disease. Sorafenib an inhibitor of many kinases was shown to benefit advanced patients. However, resistance emerges soon after initial treatment, limiting the clinical sorafenib, mechanisms still remain elusive. Thus, this study aims investigate sorafenib provide possible targets combination therapies. Through miRNA sequencing, we found that miR-486-3p downregulated in...
Computational microscopy tools, in particular lensfree on-chip imaging, provide a large field-of-view along with long depth-of-field, which makes it feasible to rapidly analyze volumes of specimen using compact and light-weight imaging architecture. To bring molecular specificity this high-throughput platform, here we demonstrate the use plasmon-resonant metallic nanoparticles automatically recognize different cell types based on their plasmon-enhanced holograms, detected reconstructed over...
Sorafenib resistance is a major obstacle to the treatment of advanced hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) are multifunctional regulators gene expression with profound impact for human disease. Therefore, better understanding biological mechanisms abnormally expressed miRNAs critical discovering novel, promising therapeutic targets HCC treatment. This study aimed investigate role miR-378a-3p in sorafenib and elucidate underlying molecular mechanisms. Methods: A novel hub was...
ObjectivesThe objectives of this study were to determine species distribution and in vitro antifungal susceptibility Candida isolates identified the multicentre China-SCAN invasive infection (ICI) intensive care units (ICUs) across China.
With voriconazole (VRC) being approved as the first choice in treating invasive aspergillosis (IA) and its increasing use treatment, a VRC-resistant strain of Aspergillus flavus, second leading cause IA after fumigatus, has emerged. The A. flavus was isolated for time from surgical lung specimen an patient with no response to VRC therapy. In order ascertain mechanism resistance, azole target enzyme genes this were cloned sequenced, 4 mutations generating amino acid residue substitutions...
Sporotrichosis is the most common deep mycosis in Northeast China which an area of high epidemicity due to contact with reeds or cornstalks. In this study, we have characterized a total 74 clinical isolates from fixed cutaneous, lymphocutaneous and disseminated forms Heilongjiang, Jilin, Liaoning provinces, respectively. All (previously as Sporothrix schenckii) were identified globosa according their phenotypic characteristics calmodulin gene sequences analysis. They subdivided into two...
Eight usnic acid derivatives, that is, usenamines A-F (1-6), usone (7), and isousone (8), together with the known (+)-usnic (9), were isolated from lichen Usnea longissima. Their structures elucidated using 1D 2D NMR MS data, absolute configurations of compounds 1 2 defined by single-crystal X-ray diffraction analyses. Compounds 1, 2, 8 showed inhibitory effects on growth human hepatoma HepG2 cells IC50 values 6.0-53.3 μM compared methotrexate as positive control, which had an value 15.8 μM....
Tinea capitis is still common in developing countries, such as China. Its pathogen spectrum varies across regions and changes over time.This study aimed to clarify the current epidemiological characteristics of tinea China.A multicentre, prospective descriptive involving 29 tertiary hospitals China was conducted. From August 2019 July 2020, 611 patients with were enrolled. Data concerning demography, risk factors fungal tests collected. When necessary, pathogens further identified by...
Enhancing video quality is critical for achieving a boosted user experience on smart devices including mobiles, televisions, and monitors. Practical hardware designs should deliver high performance with minimal resources under the stringent limitations related to bandwidth, area energy budget. The widespread usage of deep-learning algorithms in image processing tasks, super-resolution (SR) noise-reduction (NR), has further emphasized necessity energy-efficient solutions. Therefore, an...
<title>Abstract</title> Background Peritoneal metastases (PM) after radical surgery is an important reason for the treatment failure in colorectal cancer (CRC). The intraoperatively intraperitoneal perfusion chemotherapy may be effective method to prevent postoperative PM of CRC. We aimed explore safety and feasibility preventive with lobaplatin Methods Between December 12, 2017 October 17, 2019, 720 eligible CRC patients which clinical TNM stage was T4 or N + were recruited from 25...
ABSTRACT Background Microsporum canis , a dermatophyte commonly associated with pets, is leading cause of severe tinea capitis. The increasing prevalence antifungal resistance among dermatophytes poses significant global health challenge. Objectives This study aims to define the updated susceptibility profile M. enhance treatment strategies for infections. Methods analysed 348 isolates from mainland China their 11 agents, following CLSI M38‐A3 guidelines. Additionally, we investigated agents...
Trichophyton species, the leading cause of dermatophytosis globally, are increasingly resistant to antifungal treatments, concerns about effective management strategies. In light absence established resistance criteria for terbinafine and azoles, coupled with a dearth research on mechanisms in Trichophyton, susceptibility drug gene diversity were analyzed across 64 T. mentagrophytes, 65 interdigitale, 2 indotineae isolates collected China between 2001 2024 101 published strains. Analyses...
Recent advancements in 3D scene representation have underscored the potential of Neural Radiance Fields (NeRFs) for producing high-fidelity renderings complex scenes. However, NeRFs are hindered by significant computational burden volumetric rendering. To address this, Gaussian Splatting (3DGS) has emerged as an efficient alternative, utilizing Gaussian-based representations and rasterization techniques to achieve faster rendering speeds without sacrificing image quality. Despite these...
In special industrial fields such as electric submersible pump (ESP) wells, named entity recognition (NER) often suffers from low accuracy and incomplete due to the scarcity of high-quality corpora prevalence rare words nested entities. To address these issues, this study introduces a character-level convolutional neural network (char-CNN) into Flat-Lattice Transformer (FLAT) model constructs matching rules for ESP well domain, forming char-CNN-FLAT-CRF model. This achieves NER in...
Road horizontal curves, which significantly influence drivers’ visual search behavior and are closely linked to traffic safety, also constitute a crucial factor in sustainable road development. This paper uses simulation driving experiments explore the dynamic response characteristics of 27 typical subject regarding curve radius. Results show that monotonous, open environment, driver’s is biased towards inside curve; as radius increases, 85th percentile value longitudinal length gradually...
Our study is the first to compare fungal microbiome changes in atopic dermatitis (AD) patients before and after treatment with upadacitinib dupilumab. We found that more effectively restores levels observed healthy individuals, which may contribute its superior efficacy head neck (a subtype of AD). The results enhance understanding how JAK inhibitors influence skin AD.