A5061794869- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- RNA modifications and cancer
- Congenital Anomalies and Fetal Surgery
- Congenital Diaphragmatic Hernia Studies
- Liver Disease and Transplantation
- Pancreatitis Pathology and Treatment
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Vascular Malformations and Hemangiomas
- Advanced Optical Sensing Technologies
Jiaxing University
2012-2024
Sir Run Run Shaw Hospital
2012-2024
Zhejiang University
2012-2024
Zhejiang Province Institute of Architectural Design and Research
2024
Zhejiang Cancer Hospital
2020
First Hospital of Jiaxing
2014
Abstract Sorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma (HCC). However, sorafenib resistance significantly limits its therapeutic efficacy, and mechanisms underlying have not been fully clarified. Here we report that a circular RNA, circRNA-SORE (a RNA upregulated in so rafenib- re sistant HCC cells), plays significant role HCC. We found sorafenib-resistant cells depletion of substantially increases cell-killing ability sorafenib. Further studies...
NEK2 has been estimated to play an important role in cancer progression. However, its relevance hepatocellular carcinoma (HCC) not yet explored. Immunohistochemistry revealed expression was upregulated HCC. NEK2-positive patients were associated with poor prognosis after surgery compared NEK2-negative based on Kaplan-Meier curves. Deletion of reduced self-renewal properties and chemotherapeutic resistance, decreased the stemness genes cell lines. unfavorable outcomes HCC patients, regulate...
Hepatocellular carcinoma (HCC) is a heterogeneous malignancy with gender-related differences in onset and course. Androgen receptor (AR), male hormone receptor, critical the initiation progression of HCC. The role AR HCC has been mechanistically characterized anti-AR therapies have developed, showing limited efficacy. Immunotherapy targeting immune checkpoint proteins may substantially improve clinical management mechanism by which influences state remains unclear. In this study, we...
Background Although observational studies have found an association between hypothyroidism and alopecia areata, the causality of this relationship remains unclear. Objectives This study aimed to investigate genetic variants associated with their potential impact on risk developing areata. Methods genome-wide summary statistics for (30,155 cases 379,986 controls) areata (289 211,139 were obtained from IEU OpenGwas project. The inverse variance-weighted method was used as primary analysis...
The application of laparoscopic hepatectomy is gaining momentum. However, the safety and efficacy right (LRH) on hepatocellular carcinoma (HCC) are yet to be adequately evaluated. We aimed assess surgical oncological outcomes LRH for HCC by comparing it with open (ORH).Data patients who underwent from May 2007 January 2018 in our hospital were obtained. Baseline characteristics, postoperative recovery, survival compared. One-to-one propensity score matching (PSM) was used minimize selection...
Objective: Ultrasound-guided fine-needle aspiration biopsy (US-FNAB) is a safe and effective method for screening malignant thyroid nodules. The purpose of this study was to compare the diagnostic effectiveness US-FNAB nodules different sizes. Methods: A total 1085 patients with who underwent between January 2021 July 2023 were included in study. divided into three groups based on maximum diameter nodules: there 324 ≤ 5 mm Group A, 537 6 10 B, 224 > C. satisfactory specimen rate, time...
Rosai-Dorfman disease (RDD) is rare and characterized by histiocytic proliferation massive cervical lymphadenopathy. About 40% of patients have extra-nodal involvement. Opthalmic involvement seen in 10% cases. A case orbital Rosai Dorfman a 58 years old woman presented here, who was misdiagnosed as inflammatory initially. The patient did not respond to course oral prednisolone. Then complete surgical excision the mass performed histopathological examination consistent with diagnosis RDD.
Background Laparoscopic surgery is advantageous for minimal invasiveness and rapid postoperative recovery. Since the use of laparoscopic hepatectomy in liver resection 1990s, it has been performed a few institutions worldwide. Lack efficient safe techniques transaction major obstacle preventing from its further development. We developed new technique by curettage aspiration 1998. In this paper we analyze clinical outcomes after 7 years practice. Methods Altogether 59 consecutive patients...
Background: Though various hub genes for HCC have been identified in decades, the limited sample size, inconsistent bioinformatic analysis methods and lacking evaluation validation cohorts would make results less reliable, novel biomarkers risk model prognosis are still urgently desired.Methods: The Robust Rank Aggression method was applied to integrate 12 microarray datasets screen robustly stably differentially expressed candidates.The Least Absolute Shrinkage Selection Operator regression...
Objective: Few studies have compared the surgical outcomes of laparoscopic (LG) and open (OG) gastrectomy in obese patients (BMI≥30 kg/m 2 ) with gastric cancer. The current study aimed to investigate short-term LG this group patients. Methods: A total 33 cases 23 OG were identified from our cancer database. Clinicopathologic features, operative details, laboratory examination, postoperative between both groups. Regression analysis was used determine effects BMI on intraoperative outcomes....