A5072129735- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Pneumonia and Respiratory Infections
- RNA modifications and cancer
- Nosocomial Infections in ICU
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Viral-associated cancers and disorders
- Glaucoma and retinal disorders
- Genetic and phenotypic traits in livestock
- Cutaneous Melanoma Detection and Management
- Lymphoma Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Gut microbiota and health
- RNA Research and Splicing
- Microbial infections and disease research
- Genetic Mapping and Diversity in Plants and Animals
- Antibiotic Resistance in Bacteria
- Genetic Syndromes and Imprinting
- Ocular Oncology and Treatments
- Tuberculosis Research and Epidemiology
- Congenital Heart Disease Studies
Dali University
2012-2025
Ningbo University Affiliated Hospital
2024
Shanghai Children's Medical Center
2023
Shanghai Jiao Tong University
2023
Tongji University
2021-2022
Northwest A&F University
2019-2021
Sir Run Run Shaw Hospital
2021
Zhejiang University
2021
Nanjing Medical University
2013-2019
Sichuan University
2015-2017
The early postnatal period is the most dynamic and vulnerable stage in assembly of intestinal microbiota. Antibiotics are commonly prescribed to newborn preterm babies frequently used for a prolonged duration China. We hypothesized that antibiotic therapy would affect development microbiota their metabolites. To test this hypothesis, we analyzed stool metabolites 36 with or without treatment. These were divided into three groups, including two groups treated combination penicillin moxalactam...
Two histone methyltransferases, enhancer of zeste homolog 2 (EZH2) and nuclear SET domain-containing (NSD2), are aberrantly expressed in several types human cancers. However, the regulatory relationship between EZH2 NSD2 their prognostic values breast cancer (BC) have not been fully elucidated. In this study, we demonstrated that were overexpressed BC compared with benign lesions normal tissues using tissue microarray, immunohistochemistry, bioinformatic databases. Both expression associated...
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor with intermediate malignant potential, and it rarely metastasizes. We encountered unique AFH case where, the was discovered initially in unusual locations-the left lung 4th rib. Combined histological features FISH NGS analysis, diagnosis of supported, however, difficult to determine which these two primary lesion. Eight months after initial surgery, multiple systemic metastases were detected, eventually leading patient's...
Genetic factors are important in the development of glioma. Interleukin-12 (IL-12) is a multifunctional cytokine that induces Interferon (IFN)-γ secretion and plays an role antitumor immunity. Interleukin-27 (IL-27) novel IL-12 family member, present studies demonstrate IL-27 mediates potent activity. The aim this study was to investigate whether gene polymorphisms their serum levels associated with We analyzed 16974 A/C −964 A/G, 2905 T/G, 4730 T/C 210 patients glioma 220 matched controls,...
MSX1 is a favorable candidate gene for susceptibility to non-syndromic orofacial clefts (NSOCs). However, the roles of genetic variants in development NSOC are controversial and vary among human populations. In present study, 4 potentially functional single-nucleotide polymorphisms (SNPs) (rs12532 3′-untranslated region [UTR], rs3821947, rs3821949, rs4464513 5′ upstream) were investigated case-control study 602 cases 605 healthy controls. The findings showed that rs12532 located within...
Background MiR-378 has been reported to be related cell survival, tumor growth and angiogenesis may participate in hepatocellular carcinoma (HCC) development prognosis. Genetic variants primary miR-378 (pri-miR-378) impact expression contribute HCC risk survival. This study aimed assess the associations between a genetic variant susceptibility Methods We conducted case-control analyze association of rs1076064 pri-miR-378 with 1300 patients positive hepatitis B virus (HBV) 1344 HBV carriers....
Background MiR-106b-25 cluster, hosted in intron 13 of MCM7, may play integral roles diverse processes including immune response, tumorigenesis and progression. A single nucleotide polymorphism (SNP), rs999885, is located the promoter region MCM7. Our previous study showed that to G base change rs999885 provide an increased risk for HCC HBV persistent carriers by altering expression miR-106b-25 cluster. However, it unknown whether associated with prognosis intermediate or advanced...
To gain insight into the epidemiology of childhood drug resistant tuberculosis (DR-TB) in China that has second largest burden TB and number multidrug (MDR) cases world, we performed cross-sectional study to investigate resistance four first-line anti-TB drugs (isoniazid, rifampicin, streptomycin ethambutol) using Mycobacterium isolates from 196 culture-confirmed pediatric diagnosed Children's Hospital Chongqing Medical University, during 2008-2013. Univariate multivariate logistic...
This study analyzed the research hotspots and frontiers of exercise rehabilitation among cancer patients via CiteSpace. Relevant literature published in core collection Web Science (WoS) database from January 1, 2000, to February 6, 2022, was searched. Further, we used CiteSpace5.8R1 generate a network map identified top authors, institutions, countries, keywords, trends. A total 2706 related were retrieved. The most prolific writer found be Kathryn H Schmitz (21 articles). University...
ABSTRACT The novel 63,558-bp plasmid pSA-01, which harbors nine antibiotic resistance genes, including cfr , erm (C), tet (L), (T), aadD fosD fexB aacA-aphD and (B), was characterized in Staphylococcus arlettae strain SA-01, isolated from a chicken farm China. colocation of genes detected for the first time an S. plasmid. detection two IS 431 -mediated circular forms containing SA-01 suggested that may facilitate dissemination genes.
The macrolide resistance gene erm(T) was identified for the first time in a porcine Erysipelothrix rhusiopathiae isolate from swine China. novel 3,749-bp small plasmid pER29, which carries erm(T), had G+C content of 31% and four distinct open reading frames. presence pER29 increased by at least 128-fold MICs clindamycin erythromycin E. rhusiopathiae. fitness cost could be responsible low frequency
The objective of this study was to characterize plasmids coharboring 16S rRNA methylases, blaCTX-M and virulence-associated genes in Escherichia coli Klebsiella pneumoniae isolates from chickens China. A total 32 positive transconjugants exhibited coresistance amikacin cefotaxime E. (24/281) K. (8/93), were identified by conjugation experiments S1-pulsed-field gel electrophoresis. Polymerase chain reaction amplification assay detecting resistance showed that rmtB or armA gene accompanied...
The interleukin-23 (IL-23) and its receptor (IL-23R) mediate the direct antitumor activities in human hematologic malignancies including pediatric acute leukemia. Two potentially functional genetic variants (IL-23R rs1884444 T>G rs6682925 T>C) have been found to contribute solid cancer susceptibility. In this study, we conducted a case-control study 545 myeloid leukemia (AML) patients 1,146 cancer-free controls Chinese population assess association between these two SNPs risk of AML. We that...
Pleiomorphic adenoma gene 1 (PLAG1) is mainly expressed in embryonic development, and it reported to take an effect on the growth performance of mice, cattle, pigs, sheep. To explore how conservative PLAG1 different sheep breeds, effects two indel variants traits Chinese Luxi blackhead (LXBH) were firstly detected. The P2-del 30 bp P4-del 45 loci significantly related 15 (P < 0.05). Genotype ID genotype II dominant for loci, respectively. above findings indicated that mutations ovine...
<h3>Aims:</h3> To determine visual and anatomic outcomes following transpupillary thermotherapy (TTT) as a primary treatment for small choroidal malignant melanomas. <h3>Methods:</h3> 20 patients with melanomas who underwent TTT at our institution were retrospectively reviewed. Patients posterior to the equator basal diameter less than 12 mm thickness 3.5 included if lesion had documented growth or clinical risk factors growth. <h3>Results:</h3> Thirteen women seven men (mean age: 65 years,...
Background: Childhood tuberculosis (TB) is a major infectious disease causing morbidity and mortality in children yet has been largely ignored until recently. This study the first to characterize childhood TB China incorporating both Mycobacterium genetic characteristics patient data. Methods: We analyzed total of 331 culture-confirmed cases 158 M. isolates from subset sample. Univariate multivariate logistic regression analyses were performed identify host microbial predictors for having...
MicroRNAs (miRNAs) are a class of small, noncoding RNA molecules involved in carcinogenesis. It has been identified that genetic variations miRNAs contribute to cancer risk, prognosis, and survival. In the present study, we investigated whether single nucleotide polymorphisms (SNPs) several key (miR-184, miR-218, miR-124) were associated with prognosis nonsmall cell lung (NSCLC) clinical cohort study including 1001 cases. Cox proportional hazards regression models used estimate hazard ratios...
Ventilator‑associated pneumonia (VAP) is a common nosocomial infection in neonatal intensive care units with high morbidity and mortality. Bacterial biofilm the endotracheal tube (ET) provides notable persistent source of pathogens that may cause VAP, thus important for VAP detection. However, during intubation microbial investigations ET, samples are unavailable due to infeasibility collecting ET neonates. It therefore great importance find alternative sources can help identify flora. In...
Abstract To investigate the associations between functional single nucleotide polymorphisms (SNPs) in miR‐125 family and survival of non‐small cell lung cancer (NSCLC) patients, we systematically selected six SNPs located three pre‐miRNAs (miR‐125a, miR‐125b‐1, miR‐125b‐2). Cox proportional hazard regression analyses were conducted to estimate crude adjusted ratios (HRs) their 95% confidence intervals (CIs). Reporter gene luciferase assay was performed examine relationship transcriptive...