A5101775034- Hematopoietic Stem Cell Transplantation
- Gestational Diabetes Research and Management
- Gut microbiota and health
- Infant Nutrition and Health
- Antifungal resistance and susceptibility
- Bone health and osteoporosis research
- Renal Transplantation Outcomes and Treatments
- Fungal Infections and Studies
- T-cell and B-cell Immunology
- Pneumonia and Respiratory Infections
- Cancer Immunotherapy and Biomarkers
- Nosocomial Infections in ICU
- Peroxisome Proliferator-Activated Receptors
- Parathyroid Disorders and Treatments
- Traditional Chinese Medicine Studies
- Lung Cancer Treatments and Mutations
- Biomedical and Engineering Education
- Ferroptosis and cancer prognosis
- Phytoestrogen effects and research
- Alcohol Consumption and Health Effects
- RNA modifications and cancer
- Cardiovascular Health and Disease Prevention
- Neutropenia and Cancer Infections
- Ovarian function and disorders
- Lipid metabolism and disorders
Peking University People's Hospital
2023-2025
Peking University
2023-2025
China Pharmaceutical University
2025
First People's Hospital of Chongqing
2010-2024
Ningbo University
2023
Children's Hospital of Chongqing Medical University
2017-2018
Chongqing Medical University
2017-2018
China International Science and Technology Cooperation
2018
Ruijin Hospital
2004
KU Leuven
2004
To explore the influences of prenatal antibiotic exposure, intensity and postnatal exposure on gut microbiota preterm infants whether drug resistant strains in neonatal intensive care unit (NICU) over a defined period are related.Among 28 infants, there were two groups, PAT (prenatal therapy) group (12 cases), PAF free) cases). Fecal samples from both groups collected days 7 14. According to time cases divided into H (high) (11 cases) L (low) fecal day 14 collected. Genomic DNA was extracted...
The early postnatal period is the most dynamic and vulnerable stage in assembly of intestinal microbiota. Antibiotics are commonly prescribed to newborn preterm babies frequently used for a prolonged duration China. We hypothesized that antibiotic therapy would affect development microbiota their metabolites. To test this hypothesis, we analyzed stool metabolites 36 with or without treatment. These were divided into three groups, including two groups treated combination penicillin moxalactam...
Abstract Background Severe pneumonia after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is associated with high mortality. Given that cytokine, including Interleukin-6 (IL-6), play a critical role in immune-mediated organ injury patients severe COVID-19, we hypothesized cytokines may also contribute to the pathogenesis of allo-HSCT. This study aimed investigate IL-6 post-allo-HSCT and explore its underlying mechanism. Methods Serum cytokine levels were prospectively...
Our objective is to determine circulating Bone morphogenetic protein-9(BMP-9) levels in subjects with Metabolic Syndrome (MetS) and examine the relationship between BMP-9 conventional markers for MetS insulin resistance (IR). A total of 362 newly diagnosed patients along healthy controls were recruited this cross-sectional study. Circulating measured by ELISA. significantly lower compared those controls. was associated negatively Waist hip ratio (WHR), fasting blood glucose (FBG), 2-hour...
Abstract Colorectal cancer (CRC) is one of the most serious gastrointestinal tumors. The survival rate patients with advanced stages meager, so it urgent to identify new diagnostic biomarkers high sensitivity and specificity. tRNA-derived small RNAs (tsRNAs) are an emerging class non-coding that highly abundant in blood associated various physiological pathological processes. Therefore, clinical value tsRNAs diagnosing CRC requires further investigation. In this study, we identified...
Ventilator‑associated pneumonia (VAP) is a common nosocomial infection in neonatal intensive care units with high morbidity and mortality. Bacterial biofilm the endotracheal tube (ET) provides notable persistent source of pathogens that may cause VAP, thus important for VAP detection. However, during intubation microbial investigations ET, samples are unavailable due to infeasibility collecting ET neonates. It therefore great importance find alternative sources can help identify flora. In...
Abstract Background This case-control study investigated an association between breast milk jaundice (BMJ) and infants’ gut microbiome. The included determination of the diversity microbiome identification bacterial genera associated with BMJ. Methods population consisted 12 infants BMJ 22 breastfed without (control). DNA collected from feces was analyzed by PCR amplification 1% agarose gel electrophoresis, then sequenced a MiSeq system. Relative quantification bioinformatics employed to...
Ventilator-associated pneumonia (VAP) is a serious complication of mechanical ventilation leading to high morbidity and mortality among intubated neonates in neonatal intensive care units (NICUs). Endotracheal tube (ETT) biofilm flora were considered be responsible for the occurrence VAP as reservoir pathogens. However, regarding with VAP, little known about complex microbial signatures ETT biofilms. In present study, culture-independent approach based on next generation sequencing was...
Worldwide, gastric cancer (GC) is a common lethal solid malignancy with poor prognosis. Cuproptosis novel type of cell death mediated by protein lipoylation and may be related to GC prognosis.To offer new insights predict prognosis provide multiple therapeutic targets cuproptosis-related genes (CRGs) for future therapy.We collected data from several public portals, systematically estimated the expression level prognostic values CRGs in samples, investigated mechanisms using databases...
Bone morphogenetic protein9 (BMP9) has been reported to have a role in vascular development. However, there is still lack of information regarding the association between circulating BMP9 levels and cardiovascular disease humans. The goal this study measure concentrations patients with essential hypertension (HTN), coronary heart (CHD) HTN + CHD, evaluates relationship these diseases. A total 417 individuals were recruited for cross-sectional from June 2015 December 2017. These subjects...
The euglycemic–hyperinsulinemic clamp is not available in most clinical settings. An accessible and inexpensive measurement for identifying insulin resistance (IR) necessary. Our aim to assess whether the adiponectin (ADI) index (ADI/[FBG × FIns]) a better surrogate assessment of IR or metabolic syndrome (MetS). A population-based cross-sectional study was conducted including 100 healthy women 99 polycystic ovary patients. performed. Circulating ADI levels were determined by ELISA....
Objective This study aims to explore the association between alcohol intake and cognitive function in elderly Americans, including potential nonlinear relationships interactions across different subgroups. Methods The analyzed data from National Health Nutrition Examination Survey (NHANES) 2011 2014. sample included 2,675 Americans aged 60 or older. Multivariate regression analysis was used evaluate relationship function. Smooth curve fitting threshold effect were employed relationships....
This study (China Assessment of Antifungal Therapy in Hematological Diseases, CAESAR 2.0) aimed to provide updated epidemiological data on invasive fungal disease (IFD) patients undergoing allogeneic stem cell transplantation (allo-HSCT). multicenter, real-world, observational was conducted at 12 allo-HSCT centers China between January 2021 and December 2021. Consecutive adult (≥18 years) who underwent with antifungal prophylaxis were included. IFD diagnosed according the 2019 criteria...
Objective To assess the relationship between childbearing age and elements of metabolic syndrome (MS) among menopausal women in China.Materials methods One thousand one hundred forty-one subjects were divided into four interim average (ACA) groups: ≥16 < 24 years old, ≥24 29 ≥29 34 ≥34 old. The group with lowest prevalence MS was used as a control. Body mass index, waist circumference (WC) waist-to-hip ratio assessed. Plasma glucose, lipids, glycated hemoglobin (HbA1c) fasting insulin (FINS)...
Abstract Second transplantation was almost the only salvage for graft failure. However, there is no recommended regimens second transplantation, especially in haplo-SCT setting. We recently reported very encouraging outcomes using a novel method (salvage haploidentical from different donor after conditioning with fludarabine 30mg/m 2 − 6d to -2d and cyclophosphamide 1g/m 5d -4d). Herein, we our updated experience total of 30 patients this method. The median time 96.5 (33–215) days first...
Li, Yan; Wang, J. G.; G. L.; Qian, Y. S.; Gao, P. J.; Staessen, A; Zhu, D. L. Author Information