A5100461218- Parathyroid Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Advanced Glycation End Products research
- Ferroptosis and cancer prognosis
- Galectins and Cancer Biology
- Signaling Pathways in Disease
- Bioinformatics and Genomic Networks
- Gout, Hyperuricemia, Uric Acid
- Bone Metabolism and Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Connective tissue disorders research
- Climate Change and Health Impacts
- Blood properties and coagulation
- Bone and Dental Protein Studies
- Protein Tyrosine Phosphatases
- Angiogenesis and VEGF in Cancer
- Heterotopic Ossification and Related Conditions
- Immune cells in cancer
- Circadian rhythm and melatonin
- Bone health and treatments
- Liver Disease Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Bone health and osteoporosis research
- Cerebrovascular and Carotid Artery Diseases
- Diet, Metabolism, and Disease
Jiangsu University
2018-2025
Affiliated Hospital of Jiangsu University
2018-2025
Beijing Technology and Business University
2024
Weatherford College
2021
Jinzhou Medical University
2020
Dalian Medical University
2017
Chongqing Medical University
2017
Second Affiliated Hospital of Chongqing Medical University
2017
Atherosclerosis is a chronic inflammatory disease characterised by plaque accumulation in the arteries. Macrophages are immune cells that crucial development of atherosclerosis. can adopt different phenotypes, with M1 phenotype promoting inflammation while M2 counteracting it. This review focuses on factors drive polarisation macrophages towards pro-inflammatory during AS. Additionally, we explored metabolic reprogramming mechanisms and cytokines secretion macrophages. Hyperlipidaemia widely...
Advanced glycation end products play an important role in diabetic atherosclerosis. The effects of advanced (AGEs) on vascular smooth muscle cell- (VSMC-) derived foam cell formation and phenotypic transformation are unknown.Serological histological samples were obtained from amputation patients accident the Affiliated Hospital Jiangsu University. CD68/Actin Alpha 2 (ACTA2) coimmunofluorescence sections used to quantify number VSMCs with macrophage-like phenotypes. Western blotting was...
Our objective is to determine circulating Bone morphogenetic protein-9(BMP-9) levels in subjects with Metabolic Syndrome (MetS) and examine the relationship between BMP-9 conventional markers for MetS insulin resistance (IR). A total of 362 newly diagnosed patients along healthy controls were recruited this cross-sectional study. Circulating measured by ELISA. significantly lower compared those controls. was associated negatively Waist hip ratio (WHR), fasting blood glucose (FBG), 2-hour...
The clinical risks and prognosis of diabetic vascular intimal calcification (VIC) medial (VMC) are different. This study aims to investigate the mechanism VIC/VMC translocation. Anterior tibial arteries were collected from patients with foot amputation. then divided into VIC VMC groups. There plaques in all anterior arteries, while enrichment galectin-3 arterial group was significantly higher than that group. Furthermore, a macrophage/vascular smooth muscle cell (VSMC) coculture system...
Studies on the pathogenesis of diabetic cardiac remodeling are highly desired. Glucose and lipid metabolism both disordered in diabetes. disturbances promote myocardial fibrosis, apoptosis, hypertrophy through galectin-3. Galectin-3 promotes by inhibiting phosphorylation Akt Thr308 or Ser473 . The present study finds that glucose disorders important causes for damage provides novel ideas prevention treatment remodeling.
<title>Abstract</title> Nasopharyngeal carcinoma (NPC) is the most prevalent type of head - and neck cancer, its diagnosis treatment are currently facing significant challenges. This study aimed to identify biomarkers associated with NPC by performing bioinformatic analysis on GSE12452, GSE53819, GSE64634 datasets from GEO database. First, differentially expressed genes (DEGs) between normal nasopharyngeal tissues were screened. Then, these DEGs subjected RobustRank Aggregation analysis....
Few studies on the individual and combined analysis between serum uric acid (SUA) body mass index (BMI) blood pressure (BP) were conducted in individuals aged ≥45 years. We aimed to assess extent which BMI SUA their interaction affect BP Chinese middle-aged older adults.Data selected from China Health Retirement Longitudinal Study (CHARLS). A total of 5888 45 96 was included. Differences BMI, or categories evaluated by t test chi-square test. The trend related variables according four also...
Aims Diabetes will lead to serious complications, of which atherosclerosis is the most dangerous. This study aimed explore mechanisms diabetic atherosclerosis. Methods ApoE −/− mice were fed with an high-fat diet and injected streptozotocin establish in vivo atherosclerotic model. RAW 264.7 cells treated oxidized low-density lipoprotein particles (ox-LDL) high glucose produce vitro Results In this study, we showed that diabetes promoted progression potentiates macrophage proinflammatory...
Microcalcification increases the vulnerability of plaques and has become an important driver acute cardiovascular events in diabetic patients. However, regulatory mechanisms remain unclear. DJ-1, a multifunctional protein, may play potential role development complications. Therefore, this study aims to explore relationship between DJ-1 microcalcification investigate mechanisms. The vascular was determined anterior tibial arteries from foot amputated patients, apolipoprotein E-deficient...
Non-alcoholic fatty liver disease (NAFLD) has become a common chronic in the world. NAFLD is not only simple intrahepatic lesion, but also affects occurrence of variety extrahepatic complications. In particular, cardiovascular complications are particularly serious, which main cause death patients with nonalcoholic disease. To study association betweenNAFLD and AS. It may be new way to improve quality life As we all known, inflammatory response plays an important role development this study,...
Macrophage-derived foam cells play a central role in atherosclerosis, and their ultimate fate includes apoptosis, promotion of vascular inflammation, or migration to other tissues. Nε-Carboxymethyl-lysine (CML), the key active component advanced glycation end products, induced cell formation apoptosis. Previous studies have shown that Vav1/Rac1 pathway affects macrophage cytoskeleton migration, but its pathogenesis diabetic atherosclerosis is unknown. In this study, we used anterior...
Atherosclerosis is a multifaceted disease characterized by the formation and accumulation of plaques that attach to arteries cause cardiovascular vascular embolism. A range diagnostic techniques, including selective coronary angiography, stress tests, computerized tomography, nuclear scans, assess risk treatment targets. However, there currently no simple blood biochemical index or biological target for diagnosis atherosclerosis. Therefore, it interest find marker Three datasets from Gene...