A5102901290- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Nail Diseases and Treatments
- Acne and Rosacea Treatments and Effects
- Crystal structures of chemical compounds
- Contact Dermatitis and Allergies
- Magnetism in coordination complexes
- Autoimmune and Inflammatory Disorders Research
- Plant Pathogens and Fungal Diseases
- Metal-Organic Frameworks: Synthesis and Applications
- Fungal Infections and Studies
- Toxoplasma gondii Research Studies
- Synthesis and biological activity
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
- Photodynamic Therapy Research Studies
- Advanced biosensing and bioanalysis techniques
- Advanced Polymer Synthesis and Characterization
- Genetic factors in colorectal cancer
- Metal complexes synthesis and properties
- Herpesvirus Infections and Treatments
- Circular RNAs in diseases
- Single-cell and spatial transcriptomics
- Renal Diseases and Glomerulopathies
- Wnt/β-catenin signaling in development and cancer
Ningxia Medical University General Hospital
2016-2024
Ningxia Medical University
2016-2024
Xijing Hospital
2024
Southern Medical University
2014-2024
Jiangsu University
2023-2024
Air Force Medical University
2024
Qingdao Eighth People's Hospital
2021-2022
Weatherford College
2020
Fudan University
2020
Harbin Medical University
2007-2019
Two-dimensional inorganic–organic hybrid layered semiconductors are actively studied because of their naturally formed multiquantum well (MQW) structures and associated optical, photoelectric, quantum optics characteristics. Silver benzeneselenolate (AgSePh, Ph = C6H5) is a new member such materials, but has not fully been exploited. Herein, we present quasi-solution method to prepare high quality free-standing AgSePh flake-like microcrystals by reacting diphenyl diselenide (Ph2Se2) with...
Tinea capitis is still common in developing countries, such as China. Its pathogen spectrum varies across regions and changes over time.This study aimed to clarify the current epidemiological characteristics of tinea China.A multicentre, prospective descriptive involving 29 tertiary hospitals China was conducted. From August 2019 July 2020, 611 patients with were enrolled. Data concerning demography, risk factors fungal tests collected. When necessary, pathogens further identified by...
This study was performed to evaluate the analytical and practical performance of matrix-assisted laser desorption ionization-time flight mass spectrometry (MALDI-TOF MS) compared sequencing method Vitek 2 system for identification enteropathogens in clinical microbiology laboratory.Ten type strains 73 isolates representing eight genera were analyzed by MALDI-TOF MS. All also characterized gene allowing interpretation results from In addition, MS with ten Aeromonas six Salmonella.As previously...
Combination of a photosensitizer, 5-aminolevulinic acid (ALA), with photodynamic therapy (PDT) has been widely used to treat skin squamous cell carcinoma (SCC). However, portion SCC patients do not respond well PDT. The molecular reason for this resistance is clear. We hypothesize that mitogen-activated phosphorylation kinase (MAPK) plays key role in mediating To determine whether inhibition MAPK signaling enhances the anti-tumor effect ALA-PDT SCC. human line, SCL-1, was either untreated or...
Abstract As a chronic relapsing disease, psoriasis is characterized by widespread skin lesions. The Psoriasis Area and Severity Index (PASI) the most frequently utilized tool for evaluating severity of in clinical practice. Nevertheless, long‐term monitoring precise evaluation pose difficulties dermatologists patients, which time‐consuming, subjective prone to bias. To develop deep learning system with high accuracy speed assist PASI evaluation, we collected 2657 high‐quality images from...
Podocytes are an important component of the glomerular filtration barrier in kidneys. The dysfunction and apoptosis podocytes factors that can lead to progression chronic kidney disease (CKD). In CKD, angiotensin II is continuously elevated circulation considered have key roles inducing podocyte injury apoptosis. Curcumin a hydrophobic polyphenolic compound extracted from turmeric. Increasing evidence demonstrates curcumin has protective effect on kidneys CKD. However, mechanisms mediating...
Abstract Objective Salicylic acid (SA) has been used for treatment of acne different severity levels. However, there are few researches about the safety and efficacy mild to moderate acne, improvement skin condition by using 2% supramolecular salicylic (SSA) compared Davuwen Adapaline gel. Methods A multicenter, randomized, assessor‐blind parallel‐controlled study was conducted. total 500 patients (trial group: 249, control 251) with (grade I–II) facial vulgaris were recruited in this over a...
Currently, there is not much success in solving the molecular and crystal structures of long-chain metal alkanethiolate complexes [M(SC
Importance China carries a heavy burden of postherpetic neuralgia, with an unmet need for novel drugs greater efficacy and less prominent neurotoxic effects than existing calcium channel ligands. Objective To investigate the safety crisugabalin, oral α2δ-1 subunit ligand, neuralgia. Design, Setting, Participants This randomized clinical trial, carried out between November 9, 2021, January 5, 2023, at 48 tertiary care centers across had 2 parts. Part 1 was phase 3, multicenter, randomized,...
An early diagnosis of lupus nephritis (LN) has an important clinical implication in guiding treatments systemic erythematosus (SLE) settings. In this study, the concentrations Wnt-3A, Frizzled-8 (FZD-8), and Dickkopf-1 (DKK-1) Wnt signaling, as well their diagnostic values for accessing LN, were evaluated by ELISA sera urine 111 SLE patients (31 with LN 80 without LN) 70 healthy cohorts. Significantly more abundances DKK-1 protein determined both compared to cohorts (<mml:math...
Abstract Background Data on nail psoriasis (PsO) in China are scarce. Objectives To provide PsO‐related data regarding epidemiologic characteristics, manifestations, fungal infections, arthritic complaints and treatments that may facilitate improved patient management globally. Methods From August 2021 to 2022, patients with PsO were enrolled a prospective multicentre observational study at 25 hospitals China. We collected analysed concerning demography, clinical signs, detection, symptoms...
The aim of this study was to explore the effects 5‑Aza‑2'‑deoxycytidine (5‑Aza‑CdR), a DNA methylation inhibitor, on state and function WWOX gene in HO‑8910 ovarian cancer cell line. cells were divided into two groups, control group 5‑Aza‑CdR‑treated group. evaluated using methylation‑specific PCR assay. effect 5‑Aza‑CdR analyzed MTT invasion assays, as well flow cytometry. animal models established by intraperitoneal transplantation nude mice. Following treatment with 5‑Aza‑CdR,...
There is a need for effective and safe therapies psoriasis that provide sustained benefits. The aim of this study was to assess the efficacy safety tildrakizumab, an anti-interleukin-23p19 monoclonal antibody, treating moderate-to-severe plaque in Chinese patients.
Abstract Background Chloasma is a common skin hyperpigmentation condition, with treatment options ranging from topical agents to advanced interventions such as chemical peels and laser therapy. Salicylic acid, including its supramolecular form (SSA), has shown promise in managing chloasma. However, date, no multicentre randomized controlled trial of SSA for chloasma available. Objectives The purpose this study was assess the efficacy safety 30% combined 10% niacinamide treating chloasma....
Abstract Introduction: Acne vulgaris is a chronic inflammatory disease of the sebaceous glands that occurs in adolescent men and women. In recent years, incidence acne has increased year by year, so it great significance to find precise effective treatment further explore its possible mechanism action. The purpose this study will be method both traditional Chinese medicine characteristics significant effects, provides higher level evidence for acupuncture vulgaris. It also patients with more...
Objective: Vasculogenic mimicry (VM) generates an important supplementary form of blood supply in cancer, which many factors regulate.However, the effect lysyl oxidase (LOX) on VM formation is unclear.In this study, gastric cancer tissues and cells were used to investigate role LOX VM. Materials Methods:The samples collected from 49 patients with a final diagnosis cancer.According metastasis (including lymph node metastases distant metastases), divided into non-metastasis groups.Based degree...
Kerion is a severe type of tinea capitis that difficult to treat and remains public health problem.
Circular RNAs (circRNAs) have shown pivotal regulatory roles in tumorigenesis and progression. Our purpose was to analyze the role of circRNA La ribonucleoprotein 1B (circ-LARP1B; hsa_circ_0070934) cutaneous squamous cell carcinoma (CSCC) progression its associated mechanism. Cell viability, colony formation ability, migration, invasion were analyzed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5 diphenyltetrazolium bromide (MTT) assay, wound healing transwell assay. Flow cytometry performed...
Lupus nephritis (LN) is a complication of systemic lupus erythematosus (SLE) which seriously threatens the health people. Tim-1 known to be associated with pathogenesis SLE. However, role in LN still unclear.To explore expression and potential regulatory molecular mechanism LN-induced podocyte injury.An vivo model was established detect Tim-1, inflammatory cytokines autophagy-related proteins. Podocytes were treated immunoglobulin G (IgG) establish vitro then an autophagy inhibitor. RT-qPCR...
Long-chain tin( iv ) alkanethiolates (Sn(SC n H 2 +1 4 , ≥ 12) are disclosed as a class of van der Waals molecular crystals, which feature layered structure, the coexistence trans and gauche S–C bonds, all- alkyl chains.