A5100693994- Botulinum Toxin and Related Neurological Disorders
- Pain Mechanisms and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cutaneous Melanoma Detection and Management
- Advancements in Transdermal Drug Delivery
- Peptidase Inhibition and Analysis
- Atherosclerosis and Cardiovascular Diseases
- Elbow and Forearm Trauma Treatment
- Bioactive Compounds and Antitumor Agents
- Genomics and Chromatin Dynamics
- MRI in cancer diagnosis
- Acne and Rosacea Treatments and Effects
- Plant-based Medicinal Research
- Tendon Structure and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Parasitic infections in humans and animals
- AI in cancer detection
- Gout, Hyperuricemia, Uric Acid
- Healthcare and Venom Research
- Immunotherapy and Immune Responses
- Amoebic Infections and Treatments
- Multi-Agent Systems and Negotiation
- Cancer Mechanisms and Therapy
- Mast cells and histamine
- Natural Compounds in Disease Treatment
China Medical University
2012-2024
Qinghai Provincial Peoples Hospital
2023
China-Japan Friendship Hospital
2021
Background: Today's machine-learning based dermatologic research has largely focused on pigmented/non-pigmented lesions concerning skin cancers. However, studies machine-learning-aided diagnosis of depigmented non-melanocytic lesions, which are more difficult to diagnose by unaided eye, very few. Objective: We aim assess the performance deep learning methods for diagnosing vitiligo deploying Convolutional Neural Networks (CNNs) and comparing their accuracy with that human raters different...
Recent advances in large language models have led to numerous task-specialized fine-tuned variants, creating a need for efficient model merging techniques that preserve specialized capabilities while avoiding costly retraining. While existing task vector-based methods show promise, they typically apply uniform coefficients across all parameters, overlooking varying parameter importance both within and tasks. We present Sens-Merging, sensitivity-guided coefficient adjustment method enhances...
Importance China carries a heavy burden of postherpetic neuralgia, with an unmet need for novel drugs greater efficacy and less prominent neurotoxic effects than existing calcium channel ligands. Objective To investigate the safety crisugabalin, oral α2δ-1 subunit ligand, neuralgia. Design, Setting, Participants This randomized clinical trial, carried out between November 9, 2021, January 5, 2023, at 48 tertiary care centers across had 2 parts. Part 1 was phase 3, multicenter, randomized,...
Malignant melanoma is a highly aggressive skin cancer responsible for 80% of mortality, and the overall median survival in patients with metastatic only 6-9 months. Combination treatment through simultaneous administration dual drugs single nanocarrier has been demonstrated to be elegant effective combatting cancer. Herein, we employ combination therapy based on dacarbazine (DBZ), FDA approved drug all-trans retinoic acid (ATRA), promising anticancer agents loaded lipid nanoformulations...
Cryotherapy is one of the most common treatments for warts; however, pain during treatment and relatively high recurrence rates limit its use. Local hyperthermia has also been used successfully in plantar warts. The aim this study was to compare clinical effectiveness local vs cryotherapy This multi- centre, open, 2-arm, non-randomized concurrent controlled trial included 1,027 patients, who received either or treatment. Three months after treatment, achieved complete clearance 50.9% 54.3%,...
Adalimumab has been used successfully in the treatment of psoriasis. The objective study is to compare efficacy, safety, and immunogenicity between HLX03, an adalimumab biosimilar, Chinese patients with moderate-to-severe plaque In this double-blind, active-controlled, parallel-group study, 262 psoriasis were randomized (1:1) receive HLX03 or (80 mg at week 1, 40 2, then every 2 weeks) for 48 weeks. primary endpoint was improvement Psoriasis Area Severity Index (PASI) score 16 comparing...
Melanoma is an aggressive skin malignancy with a high mortality. Astrocyte elevated gene-1 (AEG-1), downstream target of Ras and c-Myc, has been implicated in the development multiple tumours, but its role melanoma remains unclear. In present study, AEG-1 was explored through silencing. Our results showed that silencing inhibited proliferation cells, induced cell cycle arrest, reduced levels cyclin A, B, D1, E, cyclin-dependent kinase 2. AEG-1silencing also apoptosis cells altered cleaved...
To evaluate the efficacy and safety of lidocaine patches in Chinese patients with postherpetic neuralgia (PHN).Patients were randomized to receive or placebo every day for 4 weeks. Efficacy endpoints included decrease analogue scale score (VAS) value at week 4, 2 1 percentage that achieved a 30% VAS value. Safety analyses conducted as well.Two hundred forty randomized. At 1, patch-treated had higher clinical response versus placebo, mean (SD) decreases compared baseline 14.01 (14.35)...
BACKGROUND We examined the anticancer potential of anthecotulide against SK-MEL-24 malignant melanoma cells. The apoptotic and autophagic effects were also investigated. MATERIAL AND METHODS cell viability human cells was evaluated by WST-1 assay. Fluorescence microscopy using acridine orange ethidium bromide staining, as well Western blot analysis, used to study induced anthecotulide. Autophagy assessed analysis fluorescence microscopy. Effects on cycle progression analyzed flow cytometry....
To investigate the cell composition and transcriptional characteristics in microenvironments of hepatic tissues mice at late stage Echinococcus multilocularis infection a single-cell level.Peri-lesion paired distal specimens were collected from two BALB/c (6 to 8 weeks old) infected with E. for RNA sequencing. The Seurat package R software was employed quality control data, multi-sample integration correction batch effects, uniform manifold approximation projection (UMAP) algorithm used...
Objective To evaluate the roles of Toll-like receptor 2 (TLR2),TLR4 and myeloid differentiation factor 88 (MyD88) in immune recognition mediation sporotrichosis by detecting their expressions skin lesions sporotrichosis.Methods Biopsy specimens were obtained from 19 patients with normal 12 healthy human controls.Immunohistochemistry was performed to observe TLR4 MyD88,and real-time fluorescence-based quantitative PCR quantify TLR2 MyD88 mRNAs.Data expressed as mean ± standard...
Objective To investigate the roles of Toll-like receptor (TLR) 3 and 9 in herpes zoster (HZ).Methods Venous blood samples were collected from 40 patients with HZ 16 normal human controls. Flow cyometry was used to detect expressions TLR3 TLR9 peripheral mononuclear cells (PBMCs) these subjects.Results The percentages PBMCs expressing significantly higher than controls (both P ＜ 0.01).The expression levels negatively correlated age onset (r =-6.23,-5.88respectively,both 0.01 ),but...
This retrospective analysis was conducted on clinical obtained DCE-MR images of 198 patients, age from 21 to 79 years(45.5±13.7). The CBAM-ResNet model developed perform the classification automatically at image-level based deep learning method using pathological examination as reference standard,then result each individual patient by ensemble learning. proposed can have an accuracy 82.69% for correctly distinguishing between benign and malignant breast tumors slice-level with a sensitivity...