A5100720636- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- Cervical Cancer and HPV Research
- Allergic Rhinitis and Sensitization
- Immune Response and Inflammation
- Reproductive tract infections research
- Autophagy in Disease and Therapy
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Autoimmune Bullous Skin Diseases
- melanin and skin pigmentation
- Genital Health and Disease
- Virus-based gene therapy research
- T-cell and B-cell Immunology
- Skin Protection and Aging
- Hair Growth and Disorders
- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Oral Health Pathology and Treatment
- Urticaria and Related Conditions
- Acne and Rosacea Treatments and Effects
- Cardiac, Anesthesia and Surgical Outcomes
- vaccines and immunoinformatics approaches
- Exercise and Physiological Responses
- Acute Kidney Injury Research
Zhongshan Hospital
2025
Fudan University
2025
National Health and Family Planning Commission
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Sir Run Run Shaw Hospital
2009-2024
Zhejiang University
2013-2024
China Automotive Engineering Research Institute
2024
Donghua University
2024
General Hospital of Shenyang Military Region
2023
Harbin Institute of Technology
2023
Abstract Background: Atopic dermatitis (AD) affects approximately 10% of adults worldwide. CM310 is a humanized monoclonal antibody targeting interleukin-4 receptor alpha that blocks and interleukin-13 signaling. This trial aimed to evaluate the efficacy safety in Chinese with moderate-to-severe AD. Methods: multicenter, randomized, double-blind, placebo-controlled, phase 2b was conducted 21 medical institutions China from February November 2021. Totally 120 eligible patients were enrolled...
Pemphigus vulgaris (PV) is a kind of IgG-mediated autoimmune blistering disease (AIBD) that characterized by loss keratinocyte adhesion in the epithelium mucous membranes or skin. Recently, pemphigus was thought to be associated with classical T helper 2 (TH2)-type cytokines such as interleukin-4 (IL-4) and interleukin-17 (IL-17) signaling pathway. A humanized monoclonal IgG4 antibody called dupilumab binds alpha subunit receptor (IL-4Rα) inhibits IL-4 interleukin-13 (IL-13), which has been...
Abstract N 6 -methyladenosine (m A) mRNA modification is the most common internal in eukaryotes, which participates a variety of biological processes. However, role m A methylation regulating autophagy induced by ischemia and hypoxia remains to be widely investigated. Here, we investigated impact METTL3, key methyltransferase, on regulation ischemic hypoxic cardiomyocytes, as well mice following acute myocardial infarction (AMI). METTL3 negatively regulated cardiomyocytes under conditions....
Abstract Atopic dermatitis is a chronic inflammatory skin disease with significant impact on the overall wellbeing of patients and their families. Crisaborole ointment, 2%, nonsteroidal phosphodiesterase 4 inhibitor approved for treatment mild‐to‐moderate atopic in multiple countries. However, key pivotal trials, low proportion patient population was Asian, therefore safety efficacy crisaborole Asian remains unclear. CrisADe CLEAR multicenter, randomized, double‐blind, vehicle‐controlled,...
The reasonable construction of Prussian blue analogue (PBA) derivative electrode materials with unique structural characteristics and multiple redox active sites has attracted extensive attention in the field energy storage. Herein, battery-type electrodes silver-decorated cobaltosic oxide (Ag@Co3O4, denoted as Ag3@CO) bismuth–iron (Bi2O3@BiFeO3, BO@BFO) have been proposed by an situ oxidation strategy PBAs. It is surprising that silver nanoparticles Ag3@CO are uniformly distributed cobalt...
Atopic dermatitis (AD) is a chronic immuno-inflammatory skin disease. Crisaborole ointment, 2%, nonsteroidal phosphodiesterase 4 inhibitor approved for the treatment of mild to moderate AD. This post hoc analysis assesses efficacy and safety crisaborole in Chinese patients aged ≥ 2 years with We evaluated from vehicle-controlled, phase 3 CrisADe CLEAR study. Patients were randomly assigned 2:1 receive or vehicle twice daily, respectively, 28 days. The primary endpoint was percent change...
Limited evidence is available on real-world management of atopic dermatitis (AD) among Asian adults. This cross-sectional study aimed to assess current approaches in AD diagnosis and Asia. Practising dermatologists regularly treating patients with moderate-to-severe were recruited from eight Asia–Pacific territories, namely Mainland China, Hong Kong, India, Japan, Singapore, South Korea, Taiwan, Thailand. A survey was administered eligible after screening taking informed consent. Data fully...
Low-risk human papillomaviruses (LR-HPVs) are the causative agents of genital warts, which a widespread sexually transmitted disease. How LR-HPVs affect autophagy and specific proteins involved unknown. In current study, we investigated impact LR-HPV11 early protein 6 (E6) on activity pathway. We transfected an HPV11 E6 (11E6) plasmid into HaCaT cells, H8 NHEK cells established stable cell line expressing protein. The differences in upstream regulatory pathways compared with those parent...
Pyoderma gangrenosum (PG) is a rare, destructive inflammatory skin disease of which painful nodule or pustule breaks down to form progressively enlarging ulcer. Ulcerations associated with PG may occur after trauma injury the skin. The etiology has not been clearly elucidated. Our report described patient heterozygous splice-donor-site mutation in NFKB1 (c.730+5G>A) causing absence exon 8 and formation truncated p105 (p.Asp191_Lys244delinsGlu; p105delEx8), led distinct symptoms high...
Psychological stress plays an important role in hair loss, but the underlying mechanisms are not well-understood, and effective therapies available to regrow rare. In this study, we established a chronic restraint (CRS)-induced growth inhibition mouse model performed comprehensive analysis of metabolomics transcriptomics. Metabolomics data showed that primary secondary metabolic pathways, such as carbohydrate metabolism, amino acid lipid metabolism were significantly altered skin tissue CRS...
FMX101 4%, as a topical foam formulation of minocycline, has been approved by US Food and Drug Administration for the treatment moderate-to-severe acne vulgaris (AV).
Acute generalized exanthematous pustulosis (AGEP) is a rare drug reaction characterized by numerous pustules on an erythematous base. In some cases, hydroxychloroquine (HCQ) can cause AGEP. There association between HLA genes and AGEP according to pharmacogenomic studies. this case report, we present the of 36-year-old female who developed HCQ-induced with HLA-typing. According our findings, patient had HLA-B 58:01, HLA-C 08:01, HLA-A 02:06. A pharmacoeconomic perspective genotyping before...
As a keratolytic, salicylic acid (SA) can be topically applied in various formulations and doses dermatology. Supramolecular SA hydrogel, new formulation with higher bioavailability, is developed commercially available nowadays. However, there still remain concerns that the long-term continual application of at low concentrations may jeopardize cutaneous barrier properties.To reveal effects 0.5-5% supramolecular hydrogel on skin normal mice models.The 0.5%, 1%, 2%, 5% or vehicle without was...
Abstract Background Atopic dermatitis (AD) is one of the most common immune and inflammatory skin disorders, leading to insufferable itching abnormalities that seriously affect life quality patients. There are still huge unmet needs for long-term effective disease control, despite currently available therapies. Evidenced by some preclinical clinical studies AD treatment with stem cells, cell could significantly effectively ameliorate symptoms. Objectives To elucidate underlying mechanisms...